Hassan Maftuh

Shahid Beheshti University

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Maryam Vosoughian

Shahid Beheshti University of Medical Sciences

Ali Dabbagh

Shahid Beheshti University of Medical Sciences

Samira Rajaei

Tehran University of Medical Sciences

Mastane Dahi-Taleghani

Shahid Beheshti University of Medical Sciences

Samira Rajaei

University of Tehran

Bahman Malek

Shahid Beheshti University of Medical Sciences

Hedayatollah Elyasi

Shahid Beheshti University of Medical Sciences

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Shahid Beheshti University of Medical Sciences

Shahid Beheshti University

Taleghani General Hospital

University of Tehran

Tehran University of Medical Sciences

Masih Daneshvari Hospital

Tunis El Manar University

Tabriz University of Medical Sciences

Iran University of Medical Sciences

Hawler Medical University

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The Duration of Spinal Anesthesia with 5% Lidocaine in Chronic Opium Abusers Compared with Nonabusers

Anesthesia & Analgesia (2007)

Maryam Vosoughian Ali Dabbagh Samira Rajaei Hassan Maftuh

It has been demonstrated that chronic opium abusers have lower thresholds for pain. In this study we sought to determine whether chronic opium abuse has any effect on the duration of spinal block by local anesthetics.In a case-controlled study, 50 opium abusers and 50 nonabusers undergoing lower abdomen operations were selected from among the patients admitted to a university hospital for elective surgery. All patients received 100 mg hyperbaric preservative-free 5% lidocaine in dextrose, intrathecally.The duration of anesthesia was much shorter in the opium abusers (60 +/- 7 min) than in the nonabusers (83 +/- 10 min) (P < 0.0001).The study documents a shortened duration of spinal block in opium abusers.

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10.1213/01.ane.0000268496.46141.4f

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765 DURATION OF SPINAL ANESTHESIA WITH LOCAL ANESTHETIC DRUGS IN CHRONIC OPIUM ABUSERS COMPARED WITH NON‐ABUSERS

European Journal of Pain (2006)

Maryam Vosoughian Hassan Maftuh Ali Dabbagh Samira Rajaei

Pain medicine

10.1016/s1090-3801(06)60768-4

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Duration of spinal anesthesia with bupivacaine in chronic opium abusers undergoing lower extremity orthopedic surgery.

PubMed (2007)

Ali Dabbagh Mastane Dahi-Taleghani Hedayatollah Elyasi Maryam Vosoughian Bahman Malek

It has been demonstrated that chronic opium abusers have lower thresholds for pain. Spinal anesthesia is a common procedure in anesthesia, which is performed through administration of drugs (usually local anesthetics) in the intrathecal space, to produce temporary pain relief. The aim of this study was to determine whether chronic opium abuse could have any possible effect on the duration of spinal block by bupivacaine.In a case-control study, 50 opium abusers and 50 nonabusers undergoing lower extremity orthopedic operations were selected from the patients admitted in Taleghani Hospital in Tehran for elective surgery. The study parameters were assimilated as much as possible, including the method of anesthesia.No statistically significant difference was noted between the two groups regarding the age, sex, and duration of surgery; while, the duration of sensory block was much shorter in the opium abusers (86.6+/-15.7 minutes) compared with the nonabusers (162+/-22.1 minutes) (P<0.0001).The study suggests a shortened duration of spinal block with bupivacaine in opium abusers. The results can propose a number of possible mechanisms including cross-tolerance mechanisms between local anesthetics and opioid compounds at the level of spinal neurons. Further molecular studies at the level of spine are suggested.

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