Ramón Rodrigo

University of Chile

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Julia Araya

University of Chile

Camilo G. Sotomayor

Hospital Clínico de la Universidad de Chile

Cleofina Bosco

AGADA Biosciences

Myriam Orellana

University of Chile

Luis A. Videla

University of Chile

Stephan J. L. Bakker

University Medical Center Groningen

Luciano Saso

Sapienza University of Rome

Stefan P. Berger

University Medical Center Groningen

Rodrigo L. Castillo

University of Chile

Lilian Thielemann

University of Chile

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University of Chile

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University Medical Center Groningen

University of Groningen

Hospital Clínico de la Universidad de Chile

Harvard University

Universitat de Barcelona

Instituto de Salud Carlos III

Dialyse Centrum Groningen

Clínica Alemana

Pontificia Universidad Católica de Chile

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SUN-309 PLASMA CADMIUM AND RISK OF LATE GRAFT FAILURE AND KIDNEY FUNCTION DECLINE IN KIDNEY TRANSPLANT RECIPIENTS

Kidney International Reports (2020)

Camilo G. Sotomayor Joppe J. Vodegel Dion Groothof Michele F. Eisenga Tim J. Knobbe

The kidney is the most sensitive organ to cadmium-induced toxicity, particularly in conditions of long-term ongoing oxidative stress. We hypothesized that, in kidney transplant recipients (KTR), the nephrotoxic exposure to cadmium represents an overlooked hazard for preserved graft functioning.

Nephrotoxicity

10.1016/j.ekir.2020.02.846

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Citations (0)

Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease

Progress in Lipid Research (2010)

Juan G. Gormaz Ramón Rodrigo Luis A. Videla Megan Beems

10.1016/j.plipres.2010.05.003

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Citations (51)

Effect of Alcohol on Water and Sodium Homeostasis

Elsevier eBooks (2005)

Ramón Rodrigo Gonzalo M. Rivera

Homeostasis

10.1016/b978-012564370-2/50012-x

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Acute and Chronic Effect of Ethanol on (Na + K)-ATPase Activity and Cyclic AMP Response to Vasopressin in Rat Papillary Collecting Duct Cells

General Pharmacology The Vascular System (1998)

Ramón Rodrigo Lilian Thielemann Myriam Orellana

Basal (medicine)

10.1016/s0306-3623(97)00380-7

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Citations (15)

Consumption of fruits and vegetables and cardiovascular mortality in renal transplant recipients: a prospective cohort study

Nephrology Dialysis Transplantation (2018)

Camilo G. Sotomayor António W. Gomes‐Neto Michele F. Eisenga Ilja M. Nolte Josephine L.C. Anderson

It currently remains understudied whether low consumption of fruits and vegetables after kidney transplantation may be a modifiable cardiovascular risk factor. We aimed to investigate the associations between consumption of fruits and vegetables and cardiovascular mortality in renal transplant recipients (RTRs).Consumption of fruits and vegetables was assessed in an extensively phenotyping cohort of RTRs. Multivariable-adjusted Cox proportional hazards regression analyses were performed to assess the risk of cardiovascular mortality.We included 400 RTRs (age 52 ± 12 years, 54% males). At a median follow-up of 7.2 years, 23% of RTRs died (53% were due to cardiovascular causes). Overall, fruit consumption was not associated with cardiovascular mortality {hazard ratio [HR] 0.82 [95% confidence interval (CI) 0.60-1.14]; P = 0.24}, whereas vegetable consumption was inversely associated with cardiovascular mortality [HR 0.49 (95% CI 0.34-0.71); P < 0.001]. This association remained independent of adjustment for several potential confounders. The association of fruit consumption with cardiovascular mortality was significantly modified by estimated glomerular filtration rate (eGFR; Pinteraction = 0.01) and proteinuria (Pinteraction = 0.01), with significant inverse associations in patients with eGFR > 45 mL/min/1.73 m2 [HR 0.56 (95% CI 0.35-0.92); P = 0.02] or the absence of proteinuria [HR 0.62 (95% CI 0.41-0.92); P = 0.02].In RTRs, a relatively higher vegetable consumption is independently and strongly associated with lower cardiovascular mortality. A relatively higher fruit consumption is also associated with lower cardiovascular mortality, although particularly in RTRs with eGFR > 45 mL/min/1.73 m2 or an absence of proteinuria. Further studies seem warranted to investigate whether increasing consumption of fruits and vegetables may open opportunities for potential interventional pathways to decrease the burden of cardiovascular mortality in RTRs.

10.1093/ndt/gfy248

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Citations (32)

Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review

Sport Sciences for Health (2019)

Fiorello Vicencio Pablo M Jimenez F Huerta Cristian Cofré-Boladós Sebastián Zamorano

Prehypertension

Aerobic Exercise

10.1007/s11332-019-00561-1

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Citations (3)

Prevention of Postoperative Atrial Fibrillation: Novel and Safe Strategy Based on the Modulation of the Antioxidant System

Frontiers in Physiology (2012)

Ramón Rodrigo

Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery with extracorporeal circulation. The pathogenesis of postoperative AF is multifactorial. Oxidative stress, caused by the unavoidable ischemia-reperfusion event occurring in this setting, is a major contributory factor. ROS-derived effects could result in lipid peroxidation, protein carbonylation or DNA oxidation of cardiac tissue, thus leading to functional and structural myocardial remodeling. The vulnerability of myocardial tissue to the oxidative challenge is also dependent on the activity of the antioxidant system. High ROS levels, overwhelming this system, should result in deleterious cellular effects, such as the induction of necrosis, apoptosis or autophagy. Nevertheless, tissue exposure to low to moderate ROS levels could trigger a survival response with a trend to reinforce the antioxidant defense system. Administration of n-3 polyunsaturated fatty acids (PUFA), known to involve a moderate ROS production, is consistent with a diminished vulnerability to the development of postoperative AF. Accordingly, supplementation of n-3 PUFA successfully reduced the incidence of postoperative AF after coronary bypass grafting. This response is due to an up-regulation of antioxidant enzymes, as shown in experimental models. In turn, non-enzymatic antioxidant reinforcement through vitamin C administration prior to cardiac surgery has also reduced the postoperative AF incidence. Therefore, it should be expected that a mixed therapy result in an improvement of the cardioprotective effect by modulating both components of the antioxidant system. We present available evidence supporting the view of an effective prevention of postoperative AF including a 2-step therapeutic strategy: n-3 PUFA followed by vitamin C supplementation to patients scheduled for cardiac surgery with extracorporeal circulation. The present study should encourage the design of clinical trials aimed to offer ne

Modulation (music)

10.3389/fphys.2012.00093

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Citations (59)

Increased production of IL-1α and TNF-α in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease

Cytokine (2006)

Jaime Poníachik Attila Csendes Juan Carlos Díaz Jorge Rojas Patricio Burdiles

Steatohepatitis

Steatosis

10.1016/j.cyto.2006.02.006

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Citations (72)

Validation of myocardial damage biomarkers as reliable predictors of infarct size and ejection fraction impairment assessed by cardiac magnetic resonance

Clinical Research and Trials (2019)

Lucía del Valle Raúl Castillo‐Astorga Rodolfo Prieto-Riveros Jaime González Rubén Aguayo

Background: Acute myocardial infarction (AMI) is the leading cause of morbidity and mortality worldwide.The final infarct size (FIS) and left ventricular ejection fraction (LVEF) are the greatest predictors of post-AMI mortality, with cardiac magnetic resonance (CMR) being the gold standard method for their measurement.Myocardial damage biomarkers, such as creatine kinase (CK) and myocardial creatine kinase (CKMB) are currently used to diagnose AMI and estimate the myocardial damage extent.It would be plausible to use them as predictors of FIS and LVEF; however, current evidence is not available up to date.Objective: To determine the potential power of plasma CK and CKMB levels as predictors of FIS and LVEF impairment, respectively, on the basis of their correlation in patients undergoing primary coronary angioplasty (PCA) following ST-elevation acute myocardial infarction (STEMI). Methodology:A retrospective analysis of PREVEC Trial (ISRCTN registry: 56034553), a multicentric, randomized, double-blind clinical study was performed.Sixty-seven patients with STEMI scheduled for PCA were enrolled.The CMR was performed 7-15 days after the event.Three radiologists blinded to clinical information measured FIS and LVEF.Total CK and CKMB were measured in peripheral venous blood at 6-8 hours after PCA.Correlation coefficient were obtained, and the tests were considered significant with a p value <0.05.The software GraphPrism 6.0 was used for the statistical analysis.Results: A significant positive correlation was obtained between levels of cardiac biomarkers and FIS [total CK (r-square 0.3, p<0.0001) and CK MB (r-square 0.15, p<0.0027)].In addition, the levels of these biomarkers showed a significant negative correlation with LVEF [total CK (r-square 0.3, p<0.0001) and CK MB (r-square 0.18, p<0.0012)]. Conclusion:These results are consistent with the view that the myocardial damage biomarkers CK and CKMB are reliable as predictors of FIS and LVEF measured by CMR in post-AMI patients.These data suggest that these biomarkers could be included in future Risk Scores.

Cardiac magnetic resonance

10.15761/crt.1000257

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Citations (1)

Placentation in the degu (Octodon degus): Analogies with extrasubplacental trophoblast and human extravillous trophoblast

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (2006)

Cleofina Bosco Chosica Buffet Mónica Bello Ramón Rodrigo Michelle Gutierrez

Syncytium

Trophoblast

Decidua

Placentation

Human placental lactogen