Tobias Rüffer

The built-in o- and p-QM (QM = quinone methide) moieties in benzo[cd]azulen-3-ones account for an easy switch between the bridged 10π- and 6π-aromatic systems in organic synthesis. We report conjugate additions, oxidative nucleophilic substitutions of hydrogen, and reversible Michael additions under very mild conditions. In the presence of thiol nucleophiles, the protonated σH-adducts could be isolated and characterized. The typical preference for either the o- or p-QM moiety led to high regioselectivity. Furthermore, the inhibitory potency of the novel benzo[cd]azulenes against the human Pim-1 kinase was evaluated.

Moiety

Quinone methide

10.1021/acs.orglett.7b00588

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Citations (9)

1,4-Dihydrobenzo[g]quinoxaline-2,3-dione

Acta Crystallographica Section E Structure Reports Online (2012)

François Eya’ane Meva Dieter Schaarschmidt Mohammad A. Abdulmalic Tobias Rüffer

The title compound, C12H8N2O2, was prepared by the reaction of the diethyl ester of naphthalenebis(oxamate) with tert-BuNH2. The molecule is nearly planar, with an r.m.s. deviation of 0.017 Å from the plane through all 16 non-H atoms. In the crystal, a three-dimensional network is formed, composed of layers of molecules along the b- and c-axis directions, due to the formation of intermolecular N—H⋯O hydrogen bonds, as well as of chains along the a-axis direction due to parallel displaced sandwich-type π–π interactions with average distances between the interacting molecules in the range 3.35–3.40 Å.

Quinoxaline

Crystal (programming language)

10.1107/s1600536812047526

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Citations (3)

CCDC 1509131: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Lydia Wrobel Tobias Rüffer Marcus Korb Heinrich Lang Michael Mehring

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1mncn9

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CCDC 1903315: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Saeed Ahmad Seerat-ur-Rehman Muhammad Nadeem Arshad Abdullah M. Asiri Tobias Rüffer

10.5517/ccdc.csd.cc21wk8s

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CCDC 810981: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Klaus Banert Frank Köhler Alexander Melzer Ingolf Scharf G. Rheinwald

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccw6wpm

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CCDC 686169: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

S. Kocher B. Walfort G. Rheinwald Tobias Rüffer H. Lang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccr10h8

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CCDC 900721: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Maik Schlesinger M. Hofmann Tobias Rüffer Dieter Schaarschmidt Heinrich Lang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccz78jz

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CCDC 901760: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Tobias Rüffer Alexander Jakob Jannie C. Swarts Heinrich Lang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccz8c1m

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CCDC 870385: Experimental Crystal Structure Determination

The Cambridge Structural Database (2013)

Martin Bette Tobias Rüffer Clemens Bruhn Joel E. Schmidt D. Steinborn

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccy6pyr

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Ruthenium Carboxylate Complexes as Efficient Catalysts for the Addition of Carboxylic Acids to Propargylic Alcohols

European Journal of Inorganic Chemistry (2015)

Janine Jeschke Christian Gäbler Marcus Korb Tobias Rüffer Heinrich Lang

Abstract Invited for the cover of this issue is the group of Heinrich Lang at the Technische Universität Chemnitz, Germany. The cover image shows the atom‐economical and highly selective addition of carboxylic acids to propargylic alcohols to give β‐oxopropyl esters. This conversion is catalyzed by ruthenium complexes, represented by the skater in our picture.

Carboxylate

10.1002/ejic.201500585

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Tobias Rüffer

Papers

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H-Index

i-10 index

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H-Index

i-10 index