Yu Ji

Hokkaido University

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Chengji J. Zhou

Liaoning University of Traditional Chinese Medicine

Kurt Reynolds

University of California, Davis

Chen Ji

Institute of Hydrobiology

Ran Gu

Zhengzhou University of Light Industry

Kazuhiro Wada

Hokkaido University

Noriyuki Toji

Hokkaido University

Shuwen Zhang

Nanjing University

Azusa Sawai

Hokkaido University

Lei Yue

Chinese Academy of Medical Sciences & Peking Union Medical College

Bo Sun

Yanbian University Hospital

Cooperative Institutions

Nanjing Agricultural University

Harbin University of Commerce

University of California, Davis

Shriners Hospitals for Children - Erie

Shihezi University

Ministry of Education of the People's Republic of China

Chinese Academy of Sciences

Soochow University

Hokkaido University

Zhejiang University

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A Genetic Variant in miR-124 Decreased the Susceptibility to Esophageal Squamous Cell Carcinoma in a Chinese Kazakh Population

Genetic Testing and Molecular Biomarkers (2017)

Fei Wu Mei Li Weiyan You Yu Ji Xiaobin Cui

Esophageal squamous cell carcinoma (ESCC) is characterized by high prevalence and mortality worldwide, and it is very highly prevalent in China. ESCC is caused by various factors, including microRNAs (miRNAs) whose expression have been shown to play a major role in tumor generation. Single nucleotide polymorphisms (SNPs) in miRNAs could affect susceptibility to numerous cancers. This study aimed to evaluate the relationship between SNPs in miR-124 and ESCC risk in the Chinese Kazakh population.A total of 239 Chinese Kazakh patients with ESCC and 227 healthy Chinese Kazakh individuals were recruited in this study. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to analyze the miR-124 rs531564 genotype.Allele G of the miR-124 rs531564 polymorphism significantly reduced the risk of ESCC in the Chinese Kazakh population [odds ratio (OR) = 0.711; 95% confidence interval (CI): 0.508-0.996; p = 0.047]. The dominant model indicated that the CG+GG genotypes were associated with significantly decreased ESCC risk compared to the CC genotype (adjusted OR = 0.586; 95% CI: 0.396-0.867; p = 0.007). Stratification analyses showed that compared with the CC genotype, the CG and CG+GG genotypes manifested reduced ESCC risks in the female group [CG vs. CC: OR = 0.472; 95% CI: 0.255-0.872; p = 0.016; (CG+GG) vs. CC: OR = 0.472; 95% CI: 0.255-0.872; p = 0.016] and the age group of <57 years old [CG vs. CC: OR = 0.456; 95% CI: 0.258-0.806; p = 0.006; (CG+GG) vs. CC: OR = 0.456; 95%CI: 0.258-0.806; p = 0.006]. The miR-124 rs531564 polymorphism showed no significant association with histological stage, lymph node metastasis, depth of invasion, or tumor/node/metastasis stage.Our findings are the first to be reported that the miR-124 rs531564 polymorphism decreased ESCC risk in the Chinese Kazakh population.

Kazakh

10.1089/gtmb.2017.0115

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Meta-Analysis of microRNAs as Potential Biomarkers for Detecting Esophageal Carcinoma in Asian Populations

The International Journal of Biological Markers (2017)

Mei Li Fei Wu Yu Ji Lan Yang Feng Li

Background An Increasing number of studies in the literature have shown that microRNAs (miRNAs) can be used as early diagnostic markers for esophageal carcinoma (EC), but their conclusions remain controversial. Hence, we performed this meta-analysis to evaluate the diagnostic accuracy of using miRNAs in EC and to provide an experimental basis for early diagnosis of the disease. Methods This meta-analysis included 39 Asian studies from 18 articles, which covered 3,708 EC patients and 2,689 healthy controls. We used a bivariate random-effects model, the chi-square test and the I 2 test to assess sensitivity and heterogeneity. Results Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of miRNAs for diagnosis of EC in Asians reached 0.798, 0.785, 3.705, 0.257 and 14.391, respectively. Additionally, the area under the summary receiver operating characteristic curve was 0.86. Subgroup analysis based on research country (China vs. Japan), sample types (plasma vs. serum) and miRNAs (single vs. multiple; singly reported miRNAs vs. repeatedly reported miRNAs) showed no significant difference in accuracy of diagnosis for each subgroup. Conclusions MiRNAs can distinguish EC patients from healthy controls. Blood-based miRNAs have better diagnostic value in detecting EC than saliva-based miRNAs, whereas both serum and plasma are recommended for clinical specimens for miRNA detection.

Diagnostic odds ratio

Subgroup analysis

10.5301/ijbm.5000296

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Notice of Retraction: Study on HepG-2 apoptosis induced by saponins isolated from asparagus and the effects on the activities of Caspase-3,8,9

Yu Ji Chen Ji Lei Yue He N. Xu Lang Lang

This article has been retracted by the publisher.

Asparagus

10.1109/esiat.2010.5568421

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An underlying motor bias shapes individuality during vocal learning

Research Square (Research Square) (2023)

Noriyuki Toji Azusa Sawai Hongdi Wang Yu Ji Rintaro Sugioka

Abstract The emergence of individuality during learned behavior is a general feature of animal species, yet the biological bases of its development remain unknown. Similar to human speech, songbirds develop individually-unique songs with species-specific traits through vocal learning. By taking advantage of songbirds as a model system for studying the neural basis of vocal learning and development, we utilized F 1 hybrid songbirds ( Taeniopygia guttata cross with T. bichenovii ) to examine the developmental and molecular mechanisms underlying individuality in vocal learning. When tutoring with songs from both parental species, F 1 pupils showed vast individual differences in their acquired songs. Approximately 30% of F 1 hybrids selectively learned either song of the two parental species, whereas others developed merged songs between the parental species. Vocal acoustic biases during vocal babbling were initially observed as individual differences in songs among F 1 juveniles, which were maintained through the sensitive period of song vocal learning. These individual differences in vocal acoustic biases appeared independently from the auditory experience of hearing biological farther’s and passive tutored songs. Furthermore, the idiosyncratic traits of F 1 hybrids’ songs were not correlated with peripheral vocal organ morphology. However, we identified unique transcriptional signatures from the glutamatergic neurons projecting from the cortical vocal output nucleus to the hypoglossal nuclei associated with individual differences in the acoustic vocal biases, even at the initial stage of vocal learning. These results indicate that a predisposed motor bias influences the individuality observed when learning new motor skills.

Vocal Learning

Babbling

Auditory feedback

Songbird

10.21203/rs.3.rs-2295275/v2

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Study on Apoptosis of Human Promyelocytic Leukemia HL-60 Cells Induced by Fucosterol via Death Receptor Pathway

Advanced materials research (2013)

Yu Ji Dong Xue Song Chen Ji

The purpose of this study is to investigate the effect of fucosterol on the induction of apoptosis and the molecular mechanism involved in Human promyelocytic leukemia HL-60 Cells. HL-60 Cells were treated with different concentrations of fucosterol at different time. MTT method was used to study fucosterol anti-tumor activity. Morphology observation was performed to determine the effects of fucosterol on apoptosis of HL-60 cells. Flow cytometry (FCM) was used to detect the cell cycle. Laser scanning confocal microscope (LSCM) was used to analyze the expressions of Fas, FasL, Fadd and Caspase-8. Caspase activity kits were used to determine the activity of Caspase-8 and Caspase-3. The results showed fucosterol could inhibit the growth of HL-60 cells, and the apoptosis morphology for 48 h treatment was obvious, which showed cell protuberance, cytoplasm concentrated and apoptotic body. Fucosterol treatment for 24 h increased the protein expression of Fas, FasL, Fadd and Caspase-8. It also showed that the activity of Caspase-3 and Caspase-8 has increased significantly. In conclusion, Fucosterol could induce HL-60 cells apoptosis via death receptor pathway.

FADD

Fas ligand

MTT assay

Promyelocytic leukemia protein

Caspase 8

10.4028/www.scientific.net/amr.790.607

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Effects of porphyromonas gingivalis lipopolysaccharide on polymorphonuclear leukocyte

Stomatology (2011)

Yu Ji

Objective The aim of our study was to determine whether the polymorphonuclear leukocyte(PMN)undergo apoptosis in response to porphyromonas gingivalis lipopolysaccharide(LPS).MethodsFreshly isolated peripheral blood polymorphonuclear leukocyte obtained from 10 healthy volunteers was incubated with(experimental group)or without(control group) LPS to investigate the capacity of LPS to induce polymorphonuclear leukocyte′s apoptosis.ResultsOur results revealed that there was a marked decrease in apoptosis of polymorphonuclear leukocyte in experimental group compared with control group(P0.05).Conclusions The findings of the present study demonstrate that LPS delays PMN apoptosis in a dose-dependent fashion.It suggests that bacterial-delayed apoptosis may be an important role in the pathogenesis of periodontal disease.

Polymorphonuclear leukocyte

Pathogenesis

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Research Advances in the Anti-Tumor Angiogenesis of Flavonoids

Applied Mechanics and Materials (2013)

Miao Yu Shu Yang Yu Ji

The flavonoids are the active ingredient of many natural medicines, it can inhibit the proliferation of many kinds of tumor cells. In recent years, a growing number of studies have shown that through various mechanisms of flavonoids inhibit the angiogenesis and tumor growth. The article reviews the research advances of the anti-tumor angiogenesis of flavonoids.

10.4028/www.scientific.net/amm.411-414.3250

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Separation of unsaturated fatty acid from Eucommia seed oil and the analysis of its α-linolenic acid content.

Shipin anquan zhiliang jiance xuebao (2013)

WU Li-ya Yang Wangen Huang Qun Yu Ji Chen Gong-xi

Linolenic acid

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Study on the Apoptosis Effect Induced by Isothiocyanates in Broccoli on Human Gastric Adenoma Cells (SGC-7901)

Zou Xiang Yu Ji Chenfeng Ji Lei Yu Lang Lang

To investigate the pro-apoptosis effect of isothiocyanates(ITCS) on human gastric adenoma cells SGC- 7901 and its mechanism. METHODS: SGC-7901 was treated with different concentrations of ITCS. MTT assay was used to evaluate the influence of ITCS on cell proliferation. Flow cytometry was used to test reactive oxygen species (ROS) levels, intracellular mitochondrial transmembrane potential (Deltapsim), and hypodiploid apoptosis peak in both SGC-7901. RESULTS: ITCS obviously inhibited proliferation of SGC-7901 cells. When treated with 0, 15, 30, 60, 120, 240 mug /mL of ITCS for 24 h, intracellular ROS levels of SGC-7901 were (1.6 plusmn 0.5)%, (2.0 plusmn 0.3)%, (5.5 plusmn0.4)%, (25.8 plusmn1.4)%, (83.7 plusmn 1.2)% and (97.4 plusmn 4.2)%, respectively; and Deltapsim were (98.6 plusmn4.3)%, (98.4 plusmn 4.8)%, (95.7 plusmn 5.4)%, (92.6 plusmn 4.0)%, (74.0 plusmn 5.6)% and (63.7 plusmn4.0)%, respectively; when treated with 0, 60, 120, 240 mug /mL of ITCS for 48 h, cell apoptotic rates of SGC-7901 were (4.3 plusmn1.6)%, (9.1 plusmn 3.8)%, (20.1 plusmn 4.2)% and (55.4 plusmn 4.9)%, respectively. CONCLUSIONS: ITCS generates ROS in both SGC-7901, which causes mitochondrial membrane permeabilization and Deltapsim decrease, therefore, leads to apoptosis.

10.1109/icbbe.2008.230

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Notice of Retraction: Effect of Asparagus polysaccharide on the number and activity of erythrocyte complement receptor 1(CD35) of S180 mice

Yu Ji Chen Ji Yong Min

This article has been retracted by the publisher.

Complement

Asparagus

10.1109/esiat.2010.5568420

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Citations (2)