Hong‐Duo Chen

China Medical University

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Papers

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i-10 index

Research Trends

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Document Type

Co-Authors

Xing‐Hua Gao

China Medical University

150

Ruiqun Qi

China Medical University

Yan Wu

Union Hospital

Huachen Wei

Mount Sinai Medical Center

Ting Xiao

Army Medical University

Yuxiao Hong

First Hospital of China Medical University

Chundi He

China Medical University

Yuan-Hong Li

Taipei Medical University

Jiu‐Hong Li

First Hospital of China Medical University

Xuegang Xu

China Medical University

Cooperative Institutions

China Medical University

277

First Hospital of China Medical University

150

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Peking University

Sichuan University

Sun Yat-sen University

Anhui Medical University

Capital Medical University

Fudan University

Author Statistics

Papers

Citation

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Research Field

Treatment of psoriasis with interleukin-12/23 monoclonal antibody: a systematic review

European Journal of Dermatology (2012)

Yan Wu Jing Chen Yuan-Hong Li Guozhang Ma John Z.S. Chen

To systematically review the efficacy and safety of interleukin-12/23 monoclonal antibody (IL-12/23 mAb) on psoriasis.Relevant randomized controlled trials (RCTs) were identified by systematic literature searches in MEDLINE, OVID, EMBASE, Cochrane Library, and the metaRegister of Controlled Trials. The efficacy outcomes and adverse effects of included RCTs were critically assessed.A total of 3365 participants in 5 multicenter RCTs were included. The RRs of most efficacy outcomes showed significant differences between i) IL-12/23 mAb and placebo at week 12/16; ii) IL-12/23 mAb and etanercept at week 12; iii) IL-12/23 mAb in high dose and IL-12/23 mAb in low dose at week 24/28. Increasing treatment times did not obviously provide additional benefit to efficacy improvement. The adverse events of IL-12/23 mAb were similar to those of controls. Antibodies to IL-12/23 mAb were mostly undetected or shown at low titer. Treatment with IL-12/23 mAb did not influence related biochemical markers.IL-12/23 mAb was effective in the treatment of psoriasis on skin lesions, health-related quality of life and psoriatic arthritis in the short-term. The increase in treatment time points was not associated with additional efficacy and dose-dependence was observed with the ongoing treatment up to week 24/28. The adverse effects were minimal and tolerable.

10.1684/ejd.2011.1559

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Citations (7)

An unusual abdominal bulge and disseminated crusts

JDDG Journal der Deutschen Dermatologischen Gesellschaft (2018)

Hao Guo Caichou Zhao Xing‐Hua Gao Hong‐Duo Chen Jiu‐Hong Li

10.1111/ddg.13724

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Citations (1)

Cyclin A1 Is Expressed in Mouse Ovary

International Journal of Medical Sciences (2014)

Hongquan Wei Yuanhong Li Chen Zhao Xuejun Jiang Hong‐Duo Chen

Cyclin A1 belongs to the type-A cyclins and participates in cell cycle regulation. Since its discovery, cyclin A1 has been shown mostly in testis. It plays important roles in spermatogenesis. However, there were also reports on ovary expression of cyclin A1. Therefore, we intended to revisit the expression of cyclin A1 in mouse ovary. Our study showed that cyclin A1 was expressed at the mRNA level and the protein level in mouse ovary. Tissue staining revealed that cyclin A1 was expressed in maturating oocytes. With the recent data on the functions of cyclins in somatic and stem cells, we also discussed the possibilities of further studies of cyclin A1 in mouse oocytes and perhaps in the oogonial stem cells. Our findings not only add to the supportive evidence of cyclin A1 expression in oocytes, but also may promote more interest in exploring cyclin A1 functions in ovary.

Cyclin D

Cyclin A2

Cyclin A

Cyclin B

Cyclin B1

Cyclin E

10.7150/ijms.8059

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Citations (6)

The Use of Traditional Chinese Medicine in Some Dermatologic Diseases: Part II--Autoimmune Bullous Disorders and Lichen Planus.

PubMed (2015)

Adone Baroni Eleonora Ruocco Teresa Russo Vincenzo Piccolo Long Geng

Over the centuries, traditional Chinese medicine (TCM) and Western medicine have traveled along parallel lines with no opportunity for collaboration. In recent decades, while an interest in TCM has been growing among Western clinicians, progress has been made in the comprehension of pathogenic mechanisms of skin disorders, and the communication between Western and Eastern medicines has become more and more intensive. In this paper, the authors discuss TCM remedies used in the treatment of autoimmune bullous disorders (pemphigus and bullous pemphigoid) and lichen planus. Future studies on the active components of the TCM will certainly shed new light on the still obscure aspects of some dermatologic diseases.

Pemphigus vulgaris

Dermatological Diseases

Western medicine

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Citations (3)

A Chinese experience of fractional Ultrapulsed CO₂laser for skin rejuvenation

Journal of Cosmetic and Laser Therapy (2010)

Yuanhong Li John Z. S. Chen Huachen Wei Li Zhang Hong‐Hui Xu

Background and objectives: The ablative fractional CO2 laser has been successfully used in treating photoaged skin in the Caucasian population. However, its application in Asian skin has not been widely reported. The purpose of this study is to observe the efficacy and safety of the protocol ‘ActiveFX’ for photodamaged facial skin in Chinese patients. Methods: A non-sequential fractional ultrapulsed CO2 laser with specific settings is used in addition to a new computer pattern generator (CPG). Twenty patients received a single-session, single-pass, ablative fractional treatment on a split face. The patients were evaluated at baseline, and 1 and 3 months (M1, M3) after the treatment using a quartile grading scale. They were also asked to assess their overall satisfaction using a 4-point scale. The improvement of the coarse wrinkles was also quantitatively analyzed with a 3D in vivo imaging system. Results: At M1 and M3, the blinded investigator rated global improvement as 2.8 ± 0.95 and 3.00 ± 0.73, which was consistent with the patients' assessment (2.55 ± 0.83 at M1 and 3.15 ± 0.88 at M3). The roughness analysis (Rz) demonstrated a significant decrease in periorbital wrinkles (p < 0.0001). Minimal and reversible adverse side effects and rapid healing were noted. Conclusions: Non-sequential fractional ultrapulsed CO2 laser resurfacing (ActiveFX) is considered an excellent treatment modality for photodamaged Chinese facial skin.

Ablative case

Rejuvenation

Quartile

Grading scale

Facial Rejuvenation

10.3109/14764172.2010.538406

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Citations (15)

Regulation of haptoglobin expression in a human keratinocyte cell line HaCaT by inflammatory cytokines and dexamethasone

Chinese Medical Journal (2008)

Lixin Xia Ting Xiao Hong‐Duo Chen Ping Li Yakun Wang

Background Haptoglobin (Hp) is one of the acute-phase proteins. Recent studies have demonstrated that Hp exerts immunoregulatory and anti-inflammatory actions and may be one of the inhibitory factors of immune reactions in the skin. In this study we investigated the regulation of Hp expression in a human keratinocyte cell line HaCaT by various cytokines and glucocorticoid. Methods HaCaT cells were cultured with IL-6 (50 ng/ml), TNF-α (20 ng/ml), IFN-γ (20 ng/ml) or IL-4 (20 ng/ml) with or without 1 μmol/L dexamethasone in 6-well plates for 12, 24 and 48 hours. Both the cells and the supernatants were collected to detect the changes of Hp expression by reverse-transcription PCR, ELISA and immunohistochemistry. Results The results showed that Hp expression were elevated at both the mRNA and protein level by the combination of IL-6, TNF-α or IL-4 with dexamethasone, whereas the three cytokines alone did not upregulate the Hp expression. IFN-γ showed no effect on the Hp expression in HaCaT cells. Conclusions These findings suggest that different inflammatory cytokines as well as glucocorticoid may be involved in the regulation of Hp expression in keratinocytes, and this may be one of the negative feedback mechanisms in inflammatory skin diseases.

HaCaT

Haptoglobin

Proinflammatory cytokine

10.1097/00029330-200804020-00014

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Citations (10)

List of contributors

Elsevier eBooks (2020)

Bilal Haider Abbasi Nisar Ahmad Abdulhameed Al-Hashem Mohammad Javed Ali Gabriel Lima Barros de Araújo

10.1016/b978-0-12-822286-7.00028-0

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Citations (0)

Split-face comparison of ultrapulse-mode and superpulse-mode fractionated carbon dioxide lasers on photoaged skin.

PubMed (2012)

Yao-Jia Luo Xue-Gang Xu Yan Wu Tianhua Xu John Z. S. Chen

Both ultrapulse-mode and superpulse-mode fractional CO2 lasers (UPCO2 and SPCO2) could be successfully used in treating photoaged skin.This evidence-based study was intended to compare the therapeutic and adverse effects of UPCO2 and SPCO2 in treating photoaged skin in Chinese subjects.Eighteen Chinese subjects with Fitzpatrick skin type IV were enrolled in a randomized, split-face trial. Subjects received SPCO2 on one half of the face and UPCO2 on the other half. Before and after photos, skin color, epidermal water content, sebum level, periorbital wrinkles, skin roughness, and self-esteem questionnaires were used.Global evaluation and subjects' self-esteem assessments showed a similar trend at 1-month and 3-month follow-up visits on both sides. The UPCO2 laser has a shorter downtime of 6.25±2.71 days compared with 6.41±2.67 days for SPCO2, but has a higher incidence of edema, spot bleeding, prolonged redness and postinflammatory hyperpigmentation. More subjects prefer SPCO2 treatment because of similar efficacy and fewer adverse effects.The effectiveness of the SPCO2 laser in treating photoaged skin is very similar to the UPCO2 laser, with less erythema, but more crusting and longer downtime.

Erythema

Carbon dioxide laser

Photoaging

Dermabrasion

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Citations (9)

The Clinical Feature of Behçet's Disease in Northeastern China

Yonsei Medical Journal (2009)

Yingbin Shang Shixin Han Jiu‐Hong Li Qiushi Ren Fangji Song

Behçet's disease (BD) is a chronic, relapsing, multi-system vasculitis of unknown aetiology with complicated and diversified clinical features predominantly involving oral and genital ulcers, and ocular and cutaneous lesions. The clinical features of this disease have been described to be different according to geographical areas and gender. We investigated the specific clinical features of BD patients in Northeastern China.116 patients involved in this study fulfilled the classification criteria of the International Study Group for BD. The clinical manifestations and results of laboratory tests of BD were recorded in each patient.The onset was typically between 20-39 years with a slight female predominance. Oral ulcers were the most common manifestation, followed by skin lesions, positive pathergy reaction/genital ulcers, and ocular lesions. Vascular lesion and epididymitis were rare in patients with BD. The frequency of erythema nodosum-like lesion and articular involvement were significantly higher in females, while gastrointestinal involvement was significantly higher in males. The results of laboratory tests showed that the human leukocyte antigen (HLA)-B*51 alleles were positive in 30.9% of patients and the immunological abnormities were present in some patients.The clinical features of BD showed geographical and gender difference. Genetic and immune factors might participate in aetiopathogenesis of BD.

Erythema Nodosum

Pathergy

Etiology

Sex organ

Epididymitis

Retinal vasculitis

Erythema

10.3349/ymj.2009.50.5.630

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Citations (18)

Higher prevalence of human herpesvirus 8 DNA sequence and specific IgG antibodies in patients with pemphigus in China

Journal of the American Academy of Dermatology (2005)