Jing Hua Li

Beijing Institute of Technology

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He Zhu

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Chuanbao Cao

China University of Mining and Technology

Xilan Ma

Beijing Institute of Technology

Yin Tang

Tongji University

Cooperative Institutions

Central South University

Beijing Institute of Technology

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Wenzhou Medical University

Central South University of Forestry and Technology

Shandong Agricultural University

Shangdong Agriculture and Engineering University

Khon Kaen University

Hebei University of Technology

Tianjin Central Hospital of Gynecology Obstetrics

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The Antithrombogenecity of Silk Fibroin Films Blending with Citric Acid and PVA

Key engineering materials (2005)

Jing Hua Li Chuanbao Cao Xilan Ma Yin Tang He Zhu

The citric acid (CA) was added to the silk fibroin and Polyvinyl Alcohol (PVA) copolymer system. The blending 4% PVA was for improving the mechanical properties of the silk fibroin films. Citric acid amount varies from 0.5% to 2% of weight. The antithrombogenecity was characterized by in vitro clot time of prothrombin time (PT), the Activated partial thromboplastin time (APTT) and thrombin time (TT). The mechanical properties of the blending films were measured and the tensile strength and breaking elongation of films reached to 25.3MPa and 102%. The anticoagulant property results indicated that APTT and TT prolonged significantly, but PT has no effective change. We discussed the relationship between the structure and properties and proposed an anticoagulant mechanism.

Fibroin

Polyvinyl Alcohol

Elongation

Thrombin time

Fineness

10.4028/www.scientific.net/kem.288-289.417

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Citations (1)

Novel Prosthesis Using Silk Fibroin for Small Caliber Vascular

Key engineering materials (2005)

Xilan Ma Chuanbao Cao Jing Hua Li He Zhu

A novel prosthesis using silk fibroin with blending heparin and sulfonated silk fibroin was studied. Anticoagulation activities of heparin/silk fibroin and sulfonated silk fibroin/silk fibroin vascular and mechanical property results showed that heparin/silk fibroin and sulfonated silk fibroin/silk fibroin vascular could meet the requirement of small caliber grafts. This study indicated that silk fibroin could be used for developing tissue engineering biological vascular grafts that could use for human coronary or low extremity artery bypasses.

Fibroin

Sericin

Vascular graft

10.4028/www.scientific.net/kem.288-289.461

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Citations (10)

Mechanical Properties and Antithrombogenecity of Blend Membrane of Silk Fibroin

Key engineering materials (2005)

Yin Tang Chuanbao Cao Xilan Ma Jing Hua Li He Zhu

The silk fibroin blend membranes were prepared by adding a small amount of poly (vinyl alcohol) (PVA) and heparin. By controlling the preparation conditions, the tensile strength and elongation at break reached to 8.86 MPa and 231.8%, respectively. Meanwhile the in vitro antithrombogenecity significant increased. The clot times (APTT, TT and PT) all exceeded the measurement limit of clot detection instrument. It is expectable using these natural materials to prepare small caliber vessel.

Fibroin

Elongation

Vinyl alcohol

10.4028/www.scientific.net/kem.288-289.445

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Citations (2)