Benjamin Simkin

University of Southern California

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STEROID EXCRETION IN OBESE PATIENTS WITH COLORED ABDOMINAL STRIAE

Obstetrical & Gynecological Survey (1962)

Benjamin Simkin Rodrigo Arce

PURPLE or red abdominal striae are one of the striking physical signs of Cushing's syndrome. However, they are not pathognomonic of this disease, since they are also seen occasionally in pregnant women, obese normal persons and in adolescent children. In these conditions white or colorless striae are quite common, but those of the tinted variety are not. In the dermatologic literature synonyms for striae are striae albicantes,1 striae atrophicae2 and striae distensae.3 In the vernacular striae are referred to as stretch marks. Various dermatologic textbooks1 2 3 4 5 ascribe this curious condition to distention or stretching of the skin, with an associated loss . . .

Pathognomonic

White (mutation)

10.1097/00006254-196212000-00021

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Citations (1)

Cushing's Syndrome Associated with a Basophilic Carcinoma of the Pituitary

Annals of Internal Medicine (1962)

Benjamin Simkin

Excerpt Only nine cases of Cushing's syndrome associated with a carcinoma of the pituitary gland are known to us to have been reported in the literature up to the present (1-8). One of these has not been reported in detail (7). Two other cases have been alluded to, but no details were given (9). The following case report is presented as another rare occurrence of Cushing's syndrome associated with a carcinoma of the pituitary gland. It may also fall within the realm of a newly described clinical entity consisting of an adrenocorticotrophin-producing pituitary tumor, following adrenalectomy for Cushing's syndrome (10-13). CASE

Pituitary Tumors

Basophilic

Pituitary neoplasm

10.7326/0003-4819-56-3-495

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Citations (9)

Exophthalmos; certain endocrinological aspects.

PubMed (1954)

Benjamin Simkin Donald W. Petit Paul Starr

The substance isolated from the anterior pituitary and responsible for the induction of thyroid hyperplasia in the tadpole (TSH) is not invariably found in increased amounts in the blood of patients with exophthalmos. The blood concentration of this substance is inversely related to the level of thyroid activity. Thyroid extract, pituitary irradiation and adrenocorticotropic hormone have not been shown conclusively to alter the course of exophthalmos.

Exophthalmos

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Citations (3)

SOME QUANTITATIVE OBSERVATIONS ON A METHAMPHETAMINE-PHENOBARBITAL ANOREXIC COMPOUND IN OBESE OUTPATIENTS

The American Journal of the Medical Sciences (1960)

Benjamin Simkin Leon Wallace

Phenobarbital

Methamphetamine

10.1097/00000441-196005000-00001

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Citations (3)

The inactivation of insulin by tissue extracts; changes in insulin sensitivity in rabbits induced by previous injections of rat liver extracts.

PubMed (1950)

Broh-Kahn Rh Benjamin Simkin Mirsky Ia

Liver tissue

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Citations (2)

Collateral circulation of the normal human heart

The American Journal of Medicine (1947)

Myron Prinzmetal Benjamin Simkin H. C. Bergman H.E. Kruger

Collateral circulation

Circulation (fluid dynamics)

10.1016/0002-9343(47)90066-1

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Citations (0)

Studies on the collateral circulation of the normal human heart coronary perfusion with radioactive erythrocytes and glass spheres.

PubMed (1948)

Myron Prinzmetal Benjamin Simkin

Collateral circulation

Circulation (fluid dynamics)

Coronary circulation

Blood circulation

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Citations (11)

Role of thyrotrophic hormone in the pathogenesis of exophthalmos

The American Journal of Medicine (1953)

Benjamin Simkin Paul Starr Charles Hancock

Exophthalmos

Pathogenesis

10.1016/0002-9343(53)90126-0

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Citations (1)

Steroids in Office Practice

Archives of Otolaryngology - Head and Neck Surgery (1961)

Benjamin Simkin

The purpose of this presentation is to review some of the basic guiding principles of steroid therapy. As an endocrinologist I would feel it presumptuous of me to spell out the detailed steroid management of each and every otolaryngological and ophthalmological disease. However, if I can help guide you through the maze of new steroid compounds currently available, and leave you with a few basic concepts concerning the use of steroids applicable to any field of medicine, I hope that this will provide a small contribution to your annual midwinter meeting.

Some Definitions

Steroidsare derivatives of the hydrocarbon,cyclopentanoperhydrophenanthrene(Fig. 1). This chemical nucleus consists of 4 rings and 17 carbon atoms. All of the naturally occurring gonadal and adrenal cortical hormones are steroid compounds. The term "steroids," employed in the title of this paper, actually refers to a specific group of steroid compounds known as corticosteroids.Corticosteroids(corticoids)

Spell

Presentation (obstetrics)

10.1001/archotol.1961.00740020703014

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Citations (0)

Response of Obese Patients to an 11 -Hydroxylase Inhibitor, Methopyrapone (SU-4885).

Experimental Biology and Medicine (1962)

Benjamin Simkin Roger M. Arce

Obese subjects exhibit 2 different responses to an 11β-hydroxylase inhibitor, methopyrapone (SU-4885), depending upon the level of the base-line urinary 17-ketogenic steroid excretion. Subjects with a normal base-line 17-KGS excretion have a normal response to methopyrapone, whereas subjects with base-line elevated urinary 17-KGS give a markedly impaired response to this inhibitor.

10.3181/00379727-111-27921

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Citations (72)