M. Klímek

University of Miami

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M. Vlašínová

Czech Academy of Sciences

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P. Ševčíková

Tomas Bata University in Zlín

Alexandra Oltová

University Hospital Brno

Jiří Vaníček

École Polytechnique Fédérale de Lausanne

Lucie Zemanová

University of Hradec Králové

Lubomir S. Hnilica

Mendel University in Brno

Maria Candida Vila

Hospital Universitario Son Espases

J Boehler

Solidus Biosciences (United States)

Yetrib Hathout

Binghamton University

K. Nagaraju

Binghamton University

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Children's National

George Washington University

Binghamton University

Imperial College London

Newcastle University

National Institutes of Health

University of Miami

Czech Academy of Sciences, Institute of Biophysics

ReveraGen BioPharma (United States)

University Hospital Brno

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THYMINE DIMERIZATION IN L‐STRAIN MAMMALIAN CELLS AFTER IRRADIATION WITH ULTRAVIOLET LIGHT AND THE SEARCH FOR REPAIR MECHANISMS

Photochemistry and Photobiology (1966)

M. Klímek

Abstract— The formation of thymine dimers in the DNA of L ‐strain mammalian cells after irradiation with ultraviolet light has been demonstrated. The amount of dimer formed rises with the dose of u.v. light. In the course of post‐irradiation incubation the thymine dimers remain in the TCA insoluble fraction and diminish as did the other thymidine‐H 3 derivatives with increasing incubation time. The dimer is not found in the soluble fraction. Thus, dimer excision (i.e. its liberation into the soluble fraction) as an expression of repair of radiation damage analogous to dark repair in E. coli was not found in these experiments.

Pyrimidine dimer

Thymine

Ultraviolet light

Strain (injury)

Thymidine

Ultraviolet

10.1111/j.1751-1097.1966.tb05806.x

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Citations (108)

CONTRIBUTION TO THE PROBLEM OF THE ORIGIN OF GIANT CELLS AFTER IRRADIATION

M. Klímek M. Vlašínová

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The role of pyrimidine dimers in the inhibition of DNA synthesis in mammalian cells after ultraviolet irradiation: the mathematical interpretation of results

Mathematical Biosciences (1970)

M. Klímek Jiří Vaníček

Pyrimidine dimer

Primer (cosmetics)

DNA clamp

10.1016/0025-5564(70)90102-1

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Toxicity of N-Ethylmaleimide and Di-t-butyl Nitroxide Radiosensitizers towards HeLa S 3 Cells in a Single Cell Culture

Nature (1966)

M. Klímek

HeLa

N-Ethylmaleimide

10.1038/2091256a0

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Citations (8)

Loss of Retinal Ganglion Cell Trophic Responsiveness Is Correlated With Reduced Electrical Activity

Investigative Ophthalmology & Visual Science (2009)

Yuanli Duan Weina Kong M. Klímek Jeffrey L. Goldberg

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The influence of deoxyribonucleic acid on ultraviolet and visible light absoption of berberine

Archives of Biochemistry and Biophysics (1959)

M. Klímek Lubomir S. Hnilica

Extinction (optical mineralogy)

Ultraviolet

10.1016/0003-9861(59)90179-1

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Citations (16)

A mathematical model of the course of the DNA synthesis in mammalian cells after ultraviolet irradiation and its use in the determination of the length of the replicon

Biosystems (1971)

J. Vanícˇek M. Klímek

Replicon

Ultraviolet

Replication

Ultraviolet light

10.1016/0303-2647(71)90016-5

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Radiosensitization of human tumour cells in vitro by N-ethylmaleinimide under hypoxic conditions.

PubMed (1966)

M. Klímek

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CORRELATION OF DOSE AND EFFECT IN OCCURRENCE OF CELLS OF GIGANTIC DIMENSIONS AFTER IRRADIATION OF CELL TISSUE

M. Klímek M. Vlašínová

limits of 1200 to 5000 r. An increase to 4000, 6000, and 8000 had no further effect. Between 150 and 800 r the effect was a linear function of the amount of irradiation. Below 75 r the effect was small. (OTS)

Linear correlation

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UV sensitive subclones induced in and selected from HeLa S3 cells

M. Klímek P. Ševčíková M. Vlašínová G. O. Schenc̀k

HeLa

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