Hamid Ahmadian-Moghadam

Tehran University of Medical Sciences

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Mitra‐Sadat Sadat‐Shirazi

Tehran University of Medical Sciences

Mohammad‐Reza Zarrindast

Tehran University of Medical Sciences

Solmaz Khalifeh

Islamic Azad University Medical Branch of Tehran

Saba Niknamfar

Mazandaran University of Medical Sciences

Ardeshir Akbarabadi

Tehran University of Medical Sciences

Heidar Toolee

Shahroud University of Medical Sciences

Reza Vafadoost

Islamic Azad University Medical Branch of Tehran

Fereshteh Seifi

Islamic Azad University North Tehran Branch

Banafsheh Salehi

University of California, Los Angeles

Somaiyeh Azmoun

Florida International University

Cooperative Institutions

Tehran University of Medical Sciences

Islamic Azad University Medical Branch of Tehran

National Drug Addiction Center

Islamic Azad University North Tehran Branch

Institute for Cognitive Science Studies

Mazandaran University of Medical Sciences

University of California, Los Angeles

Good Samaritan Hospital

Shiraz University of Medical Sciences

Scripps Clinic Medical Group

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Mineralization potential of Fresh Milk and Mineral Water Treatment on Enamel Surface after Demineralization by Citric Acid

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Reza Vafadoost Dorsa Aghajani Banafsheh Salehi Hamid Ahmadian-Moghadam

10.22038/jdmt.2022.58188.1447

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Citations (0)

Correlation among the Behavioral Features in the Offspring of Morphine-Abstinent Rats.

PubMed (2019)

Hamid Ahmadian-Moghadam Ardeshir Akbarabadi Heidar Toolee Mitra‐Sadat Sadat‐Shirazi Solmaz Khalifeh

Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation. The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the offspring of morphine-abstinent parent(s).

Positive correlation

Negative correlation

10.22122/ahj.v11i4.253

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Citations (3)

Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide

Peptides (2018)

Hamid Ahmadian-Moghadam Mitra‐Sadat Sadat‐Shirazi Mohammad‐Reza Zarrindast

Cart

Orexigenic

10.1016/j.peptides.2018.10.008

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Citations (53)

Tramadol Treatment Induces Change in Phospho-Cyclic Adenosine Monophosphate Response Element-Binding Protein and Delta and Mu Opioid Receptors within Hippocampus and Amygdala Areas of Rat Brain.

PubMed (2021)

Hamid Ahmadian-Moghadam Mitra‐Sadat Sadat‐Shirazi Somaiyeh Azmoun Reza Vafadoost Solmaz Khalifeh

Tramadol induces its unique effects through opioid pathways, but the exact mechanism is not known. The study aims to evaluate changes in the level of mu-opioid receptor (µOR), delta-opioid receptor (δOR), and phosphorylated cyclic adenosine monophosphate (cAMP) response element-binding protein (p-CREB) in the hippocampus (HPC) and amygdala (AL) areas of tramadol-treated rats.For this purpose, a total of 36 male rats were divided into two main groups for chronic or acute tramadol exposure. The animals were then exposed to 5 mg.kg-1 of tramadol, 10 mg.kg-1 of tramadol, and normal saline. The HPC and AL areas of the animals were dissected upon completion of the period. The levels of p-CREB and µOR were quantified using the western blotting technique. The data were subjected to analysis of variance (ANOVA) followed by Tukey's post-hoc analysis. The differences with the P-value lower than 0.05 were considered as significant.In the HPC and AL areas of the brain, the level of µOR was decreased by acute tramadol exposure, while no significant difference was observed by chronic tramadol exposure. Moreover, results showed that the level of p-CREB dose-dependently increased by acute and chronic tramadol exposure.HPC and AL are essential in the control of tramadol abuse. Tramadol abuse affects gene expression and transcription factors such as CREB. With acute drug tramadol treatments, the level of cAMP response element-binding protein (CREB) rapidly increases, while by chronic tramadol treatment, "peak and trough pattern is observing". The activation of the rewarding mechanism is a precise instance of addictive behavior in tramadol-treated individuals.

Cyclic adenosine monophosphate

Adenosine monophosphate

10.22122/ahj.v13i3.306

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Therapeutic potential of stem cells for treatment of neurodegenerative diseases

Biotechnology Letters (2020)

Hamid Ahmadian-Moghadam Mitra‐Sadat Sadat‐Shirazi Mohammad‐Reza Zarrindast

Stem Cell Therapy

Cell therapy

10.1007/s10529-020-02886-1

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Citations (33)

The role of calcium-calmodulin-dependent protein kinase II in modulation of spatial memory in morphine sensitized rats

Behavioural Brain Research (2018)

Mitra‐Sadat Sadat‐Shirazi Hamid Ahmadian-Moghadam Solmaz Khalifeh Setareh Nouri Zadeh‐Tehrani Maryam Farahmandfar

10.1016/j.bbr.2018.11.010

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Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats.

PubMed (2019)

Hamid Ahmadian-Moghadam Mitra‐Sadat Sadat‐Shirazi Fereshteh Seifi Saba Niknamfar Ardeshir Akbarabadi

Accumulating evidence suggests that epigenetic mechanisms play an important role in the formation and maintenance of memory within the brain. Moreover, the effect of parental drug-exposure before gestation on behavioral state of offspring has been little studied. The main objective of the current study is to evaluate the effect of parental morphine exposure on avoidance memory, morphine preference and anxiety-like behavior of offspring. The total of 32 males and 32 females were used for mating. The animals were treated with morphine. The offspring according to their parental morphine treatment was divided into four groups (n=16) including paternally treated, maternally treated, both of parents treated and naïve animals. The pain perception, anxiety-like behavior, and avoidance memory were evaluated in the offspring. In the current study, the total of 256 offspring was used for the experiments (4 tasks × 4 groups of offspring × 8 female offspring × 8 male offspring). The finding revealed that the avoidance memory and visceral pain were reduced significantly in male and female offspring with at least one morphine-treated parent. Moreover, anxiety-like behavior was reduced significantly in the male offspring with at least one morphine-treated parent. While anxiety-like behavior was increased significantly in female offspring that were treated by morphine either maternally or both of parents. The data revealed that the endogenous opioid system may be altered in the offspring of morphine-treated parent(s), and epigenetic role could be important. However, analysis of variance signified the important role of maternal inheritance.

Conditioned place preference

10.17179/excli2019-1845

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Citations (6)