Van Obberghen E

Inserm

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Jean‐Claude Scimeca

Centre National de la Recherche Scientifique

Le Marchand-Brustel Y

Nathalie Rochet

Inserm

P Freychet

Inserm

Kahn Cr

Joslin Diabetes Center

Francesco Bèguinot

Institute for Experimental Endocrinology and Oncology

Giorgio Sesti

Sapienza University of Rome

Le Marchand-Brustel Y

Inserm

Le Marchand-Brustel Y

Wieland Kieß

Leipzig University

Cooperative Institutions

Inserm

Université Côte d'Azur

Centre National de la Recherche Scientifique

Institut de Biologie Valrose

Centre Méditerranéen de Médecine Moléculaire

National Institutes of Health

Institut National de Recherche en Santé Publique

National Research Council

Hôtel-Dieu de Montréal

Heidelberg University

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[Signal transduction by the insulin receptor].

PubMed (1995)

Barón Van Obberghen E

Transduction (biophysics)

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[Insulin resistance: lessons from animal models of obesity].

PubMed (1996)

P Freychet Le Marchand-Brustel Y Van Obberghen E

The insulin resistance of animal models of obesity (the gold thioglucose obese mouse and the o b/o b mouse) is characterized by several abnormalities. At the receptor step, both the binding function (decreased number of sites) and the enzymatic, tyrosine kinase function (decreased insulin activation) are altered. At postreceptor steps, phosphatidylinositol 3-kinase (PI3-K) plays an important role in insulin signalling, particularly for the stimulation of glucose transport in muscle and adipocyte. Insulin activation of PI3-K is markedly diminished in obese mice; starving the obese animals restores normal responses of PI3-K, glucose transport, and glycogen synthesis, to insulin. These observations emphasize the multi-site, and largely reversible, nature of insulin resistance in these animal models of obesity. Similar alterations have been reported in the literature with regard to the sites of insulin resistance in human obesity and non insulin-dependent diabetes.

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Polypeptide hormones: pathology and clinical aspects.

PubMed (1984)

Van Obberghen E

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[Antibodies directed against the insulin receptor and insulin-resistant diabetes].

PubMed (1980)

Van Obberghen E Kahn Cr