Long Cheng

Sun Yat-sen University

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Rixin Liang

Chinese Academy of Medical Sciences & Peking Union Medical College

Xiaojie Yin

Wuxi Institute of Technology

Wei Xia

Tianjin Medical University General Hospital

Yue Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Hongjun Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Wan-Dan Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Jianlu Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Shuangrong Gao

Chinese Academy of Medical Sciences & Peking Union Medical College

Leilei Gong

Nantong University

Yanqiu Gao

Zhengzhou Central Hospital

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

Capital Medical University

Chinese Academy of Sciences

Nanjing Medical University

Peking University

China Academy of Chinese Medical Sciences

Harbin Medical University

Ministry of Education of the People's Republic of China

Beijing University of Chinese Medicine

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Hydrogen Sulfide Inhalation Decreases Early Blood—Brain Barrier Permeability and Brain Edema Induced by Cardiac Arrest and Resuscitation

Journal of Cerebral Blood Flow & Metabolism (2014)

Yingjie Geng Eerdunmutu Li Qier Mu Yu Zhang Wei Xia

The effects of hydrogen sulfide (H 2 S) on blood—brain barrier (BBB) and brain edema after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain poorly understood. We investigated the effects of exogenous 80-p.p.m. H 2 S gas on BBB, brain water content, neurologic outcome, and survival rate after CA and CPR. Cardiopulmonary resuscitation followed CA induced in rats by ventricular fibrillation for 6 minutes. Results show that inhalation of 80-p.p.m. H 2 S significantly reduced the permeability of the BBB in both in the cortex and hippocampus at 24 hours after resuscitation. Hydrogen sulfide also lessened brain edema in the cortex and hippocampus, ameliorated neurologic outcome as evaluated by neurologic deficit score and tape removal test, and improved the 14-day survival rate. Hydrogen sulfide also attenuated CA and CPR-induced increases of matrix metalloproteinase-9 (MMP-9) activity and vascular endothelial growth factor (VEGF) expression, and increased the expression of angiogenin-1 (Ang-1). These results indicate that inhalation of 80-p.p.m. H 2 S immediately after CPR attenuated BBB permeability and brain edema, and improved neurologic outcome and 14-day survival of rats after CA. The therapeutic benefits of H 2 S could be associated with suppression of MMP-9 and VEGF expression and increased expression of Ang-1.

Cerebral edema

10.1038/jcbfm.2014.223

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Citations (56)

Effects of the Tangningtongluo formula as an alternative strategy for diabetics via upregulation of insulin receptor substrate-1

Molecular Medicine Reports (2017)

Long Cheng Song Jun-mei Li Geng Yue Liu Yuming Wang

Tangningtongluo (TNTL), a traditional Chinese medicine, has been widely used in clinics for decades in southwest China. Its pharmacological properties and underlying molecular mechanisms remain unclear. The main goal of ethnopharmacology is to identify novel bioactive compounds derived from plants for use in indigenous medical practice. This knowledge can be used to develop novel pharmaceuticals. In the present study, hyperglycemic C57BL/KsJ‑db/db (db/db) mice were used to test the effect of TNTL on microvasculature of the retina and hypoglycemia. Metformin (Met) was selected as a positive control. 26‑week‑old mice were randomly assigned to receive either the anti‑diabetic agent Met [140 mg/kg body weight (BW)], 1.8, 0.9 or 0.45 g/kg BW TNTL, or a placebo. The fasting blood glucose, serum insulin and glycated hemoglobin levels were measured. Histopathologic examination of the pancreas was performed to confirm the hypoglycemic effect. Fluorescein angiography was applied to detect diabetes‑induced retinal angioma in the db/db mice. TNTL intake significantly decreased the fasting blood glucose level in a dose‑dependent manner. Additionally, TNTL intervention resulted in a significant decrease in the insulin resistance index. Notably, TNTL treatment markedly reduced the speed of retinal degeneration and mildly reversed microvascular caliber degeneration. Western blot analysis indicated that upregulation of phosphorylated insulin receptor substrate‑1 (p‑IRS‑1) by the administration of TNTL may be strongly involved in the improvement of insulin resistance. In conclusion, TNTL exerted a strong hypoglycemic effect and reversed retinal degeneration via upregulation of ISR‑1. The present findings provide important scientific evidence supporting TNTL as an effective alternative approach for the management of Type 2 diabetes mellitus.

Glycated hemoglobin

IRS1

10.3892/mmr.2017.6679

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Protective effects of Yindanxinnaotong capsule in a rat model of myocardial ischemia/reperfusion injury

Deleted Journal (2014)

Wan-Dan Wang Lan Wang Hongjun Yang Jianlu Wang Xiaojie Yin

To investigate the effects of Yindanxinnaotong capsule (YDXNTC) and main components compatibility and ratios on myocardium against ischemia/reperfusion injury and the effect's underlying mechanism.Myocardial ischemia/reperfusion injury (MIRI) was induced by ischemia for 30 min and reperfusion for 30 min. Electrocardiogram data and coronary flow were recorded, and superoxide dismutase (SOD), malondialdehyde (MDA), lactate dehydrogenase, creatine kinase-MB, cardiac troponin T and I (cTnT, cTnI) and interleukin-1β, interleukin-8, interleukin-18 (IL-1β, IL-8, IL-18) in myocardium were measured. Hypoxia/reoxygenation and hydrogen peroxide (H2O2) injury were induced by hypoxia for 3 h/reoxygenation for 2 h, and 100 μM H2O2 for 1 h, respectively, in vitro rat myocardial cells (H9c2). Cell viability, SOD, MDA, cTnT and inflammatory factors (IL-1β, IL-8 and IL-18) were determined, and Toll-like receptor 4 (TLR-4) expression was measured by western blotting.In the isolated heart experiment, elevated heart function, coronary flow and SOD levels, and decreased MDA levels and inflammatory factors were noted in the YDXNTC, main components and main components compatibility groups. Ventricular tachycardia/ventricular fibrillation occurrence decreased in the ginkgo biloba extract (GBE), and GBE and salvia miltiorrhiza ethanol extract compatibility (SM-E, GSEC) groups. Lactic dehydrogenase levels decreased in the YDXNTC and aqueous extract of salvia miltiorrhiza (SM-H) groups. Creatine kinase-MB decreased with GBE, SM-E, SM-H and GSEC treatment, and cTnI and cTnT levels decreased with GSEC. In the in vitro cell study, YDXNTC and main components ratios improved cell viability and SOD levels, and suppressed MDA, cTnT and inflammatory factors. TLR-4 expression was down-regulated.YDXNTC and main components compatibility showed protective effects on MIRI in this rat model and in vitro study. Regulating the Toll-like receptor signaling pathway may affect the mechanism.

Salvia miltiorrhiza

Malondialdehyde

Creatine kinase

10.1016/s0254-6272(15)30085-6

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VITS Test Suit: A Micro-benchmark for Evaluating Performance Isolation of Virtualization Systems

Pingpeng Yuan Chong Ding Long Cheng Shengli Li Hai Jin

Virtualization technology improves the resource utilization, but also raises the probability of resource contention. Thus, it arises one problem, namely how about performance isolation among VMs. To answer the question, benchmarks are highly required to evaluate performance isolation. However, few benchmarks to give solutions to the problem are available. Especially, there does not exist a micro-benchmark to measure how the performance of individual primitive operations varies with the type of misbehavior. In the paper, we present VITS - a micro-benchmark to evaluate the performance isolation of virtualization system. VITS Test Suite can test both software and hardware performance isolation. It is mainly consisted of six interference programs, which respectively test the performance isolation of cache, memory bandwidth, memory space, CPU, network and disk. VITS Test Suite provides results for user to analyze the performance isolation problem of the virtualization system along with the underlying hardware. Besides, we test Xen using VITS test suit. The experimental results show that, the cache, memory and disk performance isolation still have some big weak points to improve, in other words, the current virtualization system Xen is still unfair in fine-grained resource share.

Isolation

Benchmark (surveying)

Service virtualization

Test suite

10.1109/icebe.2010.71

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Citations (7)

DISTINGUISH ALPINIA ZERUMBET FROM OTHER AMOMUM VILLOSOM

Guizhou kexue (2004)

Xun Chen Long Cheng

This paper has a studyon the morphologyof Alpinia zerumbet, compares with other main species as Amomum villosomspice, and clarifies some morphological characteristics of Alpinia zerumbet that is called as Alpinia villosomt, Amomum villosom, Amomum kwangsiense, Amomum scahatinum, Amomum aurantiac, Amomum hongtsaoko,etc.by ordinary people.

Alpinia

Zingiberaceae

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Quantitative Determination of 15 Active Components in Lepidium meyenii with UHPLC-PDA and GC-MS

Journal of Analytical Methods in Chemistry (2021)

Yao-qing Xu Sanyang Qiao Zi-qian Wang Meng-yao Cui Daopeng Tan

In this study, a method using ultrahigh-performance liquid chromatography with photodiode array (UHPLC-PDA) was established and validated for the simultaneous quantification of 10 active components, including eight macamides and two glucosinolates, in Lepidium meyenii (maca). A gas chromatographic mass spectroscopy (GC-MS) method was used to determine the levels of three benzyl isothiocyanates and two sterols in maca. Liquid chromatographic separation was achieved on a Waters Acquity UHPLC HSS T3 column (2.1 mm × 100 mm, 1.8 μm) with gradient elution over 15 min. The mobile phase was (B) acetonitrile-(A) 10 mM aqueous ammonium phosphate, and the detection wavelength was 210 nm. The gas chromatographic separation was performed on an SH-Rxi-1 MS column, and the ionization mode was electron ionization (EI). Two methods were confirmed to have desirable precision (RSD < 1.58%), repeatability (RSD < 1.97%), stability (RSD < 1.76%), and good linearity (R2 ≥ 0.999) within the test range. The recoveries were in the range of 96.79–109.99%, with an RSD below 2.39%. We applied the established methods and successfully analyzed 15 compounds in maca processed under different drying conditions, providing a comprehensive reference for maca processing method of development. In summary, this study provided two rapid and effective methods for the quantification of 15 active components, which contributed to the in-depth maca quality control and provided a reference for the development of maca products.

Repeatability

Chromatographic Separation

10.1155/2021/6333989

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Citations (5)

Activity detection of lactic acid bacteria based on fluorescence color difference of boron and nitrogen co-doped carbon dots

Food Bioscience (2025)

Zhixin Xie Ming Cao Yongshi Chen Long Cheng Shuaifan Qin

Carbon fibers

10.1016/j.fbio.2025.105880

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Identification and evaluation of the chemical similarity of Yindan xinnaotong samples by ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry fingerprinting

Journal of Separation Science (2015)

Leilei Gong Haiyu Xu Lan Wang Xiaojie Yin Huijun Yuan

Yindan xinnaotong, a compound preparation used in traditional Chinese medicine, is composed of eight herbs: Ginkgo biloba leaf (yinxingye), Salvia miltiorrhizae (danshen), Herba gynostemmatis (jiaogulan), Erigerontis herba (dengzhanxixin), Allii sativi bulbus (dasuan), Notoginseng radixe rhizoma (sanqi), Crataegi fructus (shanzha), and Borneolum (tianranbingpian). Yindan xinnaotong is primarily used to treat cardiovascular and cerebrovascular diseases. However, to date, no scientific methods have been established to assess the quality of Yindan xinnaotong. Therefore, a combinatorial method was developed based on chemical constituent identification and fingerprint analysis to assess the consistency of Yindan xinnaotong quality. In this study, ultra high performance liquid chromatography coupled with time‐of‐flight mass spectrometry was used to identify the chemical components of Yindan xinnaotong soft capsules. Approximately 74 components were detected, of which 70, including flavonoids, ginkgolide, phenolic acid, diterpenoid tanshinones, and ginsenoside, were tentatively identified. A fingerprint analysis was also conducted to evaluate the uniformity of the quality of Yindan xinnaotong soft capsules. Ten batches of Yindan xinnaotong soft capsules were analyzed. All of the resulting chromatograms were imported into the “Similarity Evaluation System for Chromatographic Fingerprints of TCM” (Chinese Pharmacopoeia Commission, version 2004A). The similarity scores of common peaks from these samples ranged from 0.903–1.000, indicating that samples from different batches were highly correlated.

Identification

10.1002/jssc.201500836

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Citations (32)

Clinical diagnosis and treatment of peripherally inserted central catheter related upper extremity deep venous thrombosis

Biomedical Research-tokyo (2017)

Xuming Bai Xingshi Gu Long Cheng Qiang Yuan Jian Jing

Objective: This study aimed to investigate clinical diagnosis and treatment of Peripherally Inserted Central Catheter (PICC) related deep vein thrombosis. Materials and Methods: A retrospective study was performed for 19 cases of patients with concurrent upper extremity deep vein thrombosis after inserting PICC from August 2011 to December 2014 in our hospital. Results: There were 8 cases and 11 cases with PICC in the right upper extremity and left upper extremity, respectively. All 19 cases had swelling of the upper extremities and discomfort after activity, and 18 cases had varying degrees of pain after activity. By ultrasonography 18 cases were diagnosed with deep vein thrombosis and 1 case with suspected deep vein thrombosis. All 19 patients underwent the indwelling thrombolysis catheter-directed thrombolysis based on anticoagulation therapy, thrombolysis time was 2-6 (3.16 ± 1.10 d), including 16 cases (89%) at grade III thrombolysis and 3 cases (11%) at grade II thrombolysis. 17 patients (89.5%) were clinically recovered and 2 cases (10.5%) were improved, with a total efficiency of 100%. No serious complication was noticed during thrombolysis. After thrombolysis, four cases were diagnosed as phlebostenosis and received stent implantation treatment. During follow-up of 6-36 months, no cases had recurred thrombosis and post-thrombotic syndrome. Conclusion: PICC related deep vein thrombosis could be diagnosed by color Doppler ultrasonic with venography as a supplement. Catheter-directed thrombolysis technique is characterized by short thrombolysis time, safety and efficiency for the treatment of C related deep vein thrombosis.

Venography

Post-thrombotic syndrome

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The Clinical Efficacy of Yindanxinnaotong Soft Capsule in the Treatment of Stroke and Angina Pectoris: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine (2017)

Long Cheng Yue Liu Xiaobo Sun

Objective . To systematically evaluate the clinical efficacy of Yindanxinnaotong (YD) soft capsule in adult patients with cardiovascular diseases (stroke and angina pectoris). Methods . We electronically searched databases including Medline, PubMed, Chinese National Knowledge Infrastructure (CNKI), Cqvip Database (VIP), and Wanfang Database for published articles of randomized controlled trials (RCTs) of YD capsule in treating stroke and angina pectoris. The meta-analysis was performed using RevMan 5.3 software. Results . 49 RCTs involving 6195 subjects with cardiovascular diseases (angina pectoris and stroke) were included. Compared with western conventional medicine (WCM) and/or other Chinese medicines, YD plus WCM therapeutic regimen could significantly improve the efficacy rate (RR = 1.21, 95% CI (1.17, 1.25), P<0.00001 for angina pectoris, RR = 1.24, 95% CI (1.18, 1.31), P<0.00001 for stroke), showing the clinical value. In addition, the therapeutic efficiency of WCM plus YD capsule regimen is better than that of WCM alone in improving CRP (MD = −2.07, 95% CI (−3.97, −0.17), P=0.03 <0.05) and TG (MD = −0.37, 95% CI (−0.52, −0.23), P<0.0001). Conclusion . YD is effective in the treatment of cardiovascular diseases (angina pectoris and stroke) in adults, and WCM plus YD therapeutic regimen can significantly improve the effective rate in the clinic.

Stroke

Regimen

10.1155/2017/2060549

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Citations (6)