Nasopharyngeal carcinoma is a prevalent head and neck cancer, especially in Southeast Asia. Although its potential for distant metastasis is well established, metastasis to the breast has seldom been reported. To the best of our knowledge, this is the fourth report of a case of nasopharyngeal carcinoma metastasizing to bilateral breasts. A 35-year-old patient presented with left nasal obstruction, epistaxis, and a palpable mass in her left breast, without any cervical or axillary lymph nodal enlargement. Radiological examination with contrast-enhanced computed tomography scan and magnetic resonance and imaging of breast revealed the presence of enhancing mass lesions in bilateral breasts. Histopathology of the nasal mass was suggestive of undifferentiated nasopharyngeal carcinoma. Breast fine needle aspiration revealed an abundance of metastatic squamous cells. Immunohistochemistry examination was positive for chromogranin A, synaptophysin, and cluster of differentiation-56, confirming the diagnosis of a primary nasopharyngeal malignancy metastasizing to bilateral breasts. Differentiation between metastatic disease and a coexisting second primary is imperative for planning appropriate treatment and defining the further outcomes.

Synaptophysin

Histopathology

Breast carcinoma

10.7759/cureus.27497

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Citations (3)

Pseudogaucher cells obscuring multiple myeloma: a case report

Cases Journal (2009)

Vijay Saroha Parul Gupta Meeta Singh Tejinder Singh

Gaucher-like or pseudo-Gaucher cells have been noted in a variety of conditions including acute lymphoblastic leukemia, Hodgkin's disease, thalassemia, and multiple myeloma. They have an eccentric, lobulated nucleus, foamy cytoplasm but lack the tubular inclusions seen in Gaucher cells. The pseudo-Gaucher cells have distinct appearances on electron microscopy which distinguish them from true Gaucher cells.Increased pseudo-Gaucher cells probably reflects the increased load of leukocyte membrane derived glucosylceramide presented to macrophages under conditions of high cell turnover when the normal pathways for its removal may be saturated.We present a case of a 72-year-old Indian Aryan female, in which the bone marrow contained sheets of histiocytes with features mimicking gaucher cells. These pseudo-Gaucher cells obscured neoplastic plasma cells causing diagnostic difficulty.

10.1186/1757-1626-2-9147

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Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature

World Journal of Surgical Oncology (2019)

Lovenish Bains Pawanindra Lal Anubhav Vindal Meeta Singh

Villous adenomas are dubiously benign lesions, which are difficult to interpret because of their malignant potential. Distal villous adenomas present with bleeding or mucus discharge. Giant adenomas are not amenable for endoscopic or transanal resection. Only few isolated cases have been reported by laparoscopic resection. We present our case of a circumferential giant villous adenoma of the rectum managed successfully by laparoscopic ultra-low anterior resection with colo-anal anastomosis with a review of literature in regard to their malignant potential.A 62-year-old lady presented with complaints of painless bleeding per rectum and a fleshy mass protruding from the anal canal which on digital rectal examination appeared a large soft velvety flat mass with mucus discharge. Colonoscopy showed circumferential irregular, friable, edematous mucosa in rectum extending for 15 cm. Computed tomography showed a large heterogeneously enhancing polypoid mass lesion in the rectal wall involving the entire rectum. The patient underwent laparoscopic low anterior resection with colo-anal anastomosis and protecting loop ileostomy. Histopathological examination of the resected specimen revealed villous adenoma of the rectum with moderate to severe dysplasia.Villous adenomas are sessile growths lined by dysplastic glandular epithelium, whose risk of malignancy is especially high up to 50% when greater than 2 cm in size. Large size, villous content, and distal location are all associated with severe dysplasia in colorectal adenomas. Large villous rectal tumors, particularly of circumferential type pose a great challenge for endoscopic or transanal removal. Henceforth, open or laparoscopic surgery is required for these cases.Giant rectal villous polyps are usually unresectable by endoscopic methods or transanal endoscopic microsurgery and are associated with a high rate of unsuspected cancer which requires a formal radical oncologic resection. As per current data, the combined risk of dysplasia/malignancy is about 83% with 50% risk of dysplasia and frank malignancy in 33% of cases of giant rectal villous adenomas of more than 8 cm in size. Laparoscopic colorectal resection is safe and effective.

Villous adenoma

Tubular adenoma

10.1186/s12957-019-1650-4

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Successful hymenectomy in a young girl in imperforate hymen

Journal of Institute of Medicine Nepal (1998)

Meeta Singh Asma Rana Rajshree Jha Geeta Gurung Bimal Thapa

An imperforate hymen may exist at the lower end of the vagina. This is due to failure in breakdown of the partition between the mullerian and sinovaginal bulb, contributing to the formation of vagina. We are presenting a case of a fourteen-year girl who was diagnosed as haematocolpus with imperforate hymen from history and clinical examination. Diagnosis was reconfirmed with abdominal ultrasonogram after evacuation of bladder, who had urgent surgical treatment (incision and excision) and relief of symptoms of lower abdominal pain and inability to pass urine.

Girl

Hymen

10.59779/jiomnepal.51

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Fine needle aspiration cytology of primary thyroid non-hodgkins lymphoma

Journal of Cancer Research and Therapeutics (2022)

Meeta Singh Gunjan Nain Shyama Jain Sarika Singh Vikas Malhotra

Twelve cases of Primary Thyroid Non-Hodgkin's Lymphoma (PT-NHL) were retrieved from the records suspected or diagnosed as NHL on fine needle aspiration cytology (FNAC) over a period of nine years from 2010-2018. During this period 5236 patients underwent thyroid FNAC;of these 685 cases were diagnosed under Bethesda Caregory V and VI. Thyroid NHL constituted 0.23 % of all thyroid FNA (12/5236 cases)and 1.7% (12/685) of all thyroid malignancies. Patients ranged in age from 40-61 years with Female:Male 7:5. All patients presented with thyroid enlargement (5-14 cms), and were of two months to five years duration. Patients had history of tobacco intake (smoking/chewing)in nine cases (75%). Thyroid function tests showed hypothyroidism in four (33%), positive antithyroid antibodies in three (25%) and; two cases(16.7%) were known cases of Hashimotos thyroiditis with follow up.Eight cases (66.7%) had monomorphic large cell morphology,other four had mostly intermediate cell types (33.3%). A panel of immunocyto/ histochemistry (ICC/ IHC) showed CD 19 and CD 20 positivity in all cases;sixof these could be correlated on Flow cytometry (FC) with expression of FMC7, CD20, CD19 with kappa light chain restriction (5) and Lambda (1). FC findings corroborated completely with IHC on biopsy sections. The final diagnosis were Diffuse large B cell Lymphoma (DLBCL,8) and MALT- Lymphoma(4). The follow up was available in DLBCL (4) and MALT- Lymphoma (1). CHOP therapy were given in all patients followed by radiotherapy in DLBCL; one patient of DLBCL died following pulmonary complications, rest are well and alive on follow-up.PT-NHL is rare in India. DLBCL is the commonest histological type reported. In the present study, tobacco exposure has shown strong association. Combined FNAC-FC provide definitive diagnosis and thus can replace histopathology reducing turn around time.FNAC -FC provides a definitive diagnosis and thus can reduce turnaround time.

Thyroid lymphoma

10.4103/jcrt.jcrt_234_20

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Histopathological Evaluation of Prostate Lesions: A Comprehensive Approach

IntechOpen eBooks (2024)

Meeta Singh Shabnam Singh Nita Khurana Neha Pandey Vipul Ranjan Bhatt

This chapter encompasses the spectrum of prostatic diseases seen routinely in the evaluation of prostate biopsy or resection specimens. It covers the basic anatomy and histology, along with tissue examination and processing. The common benign conditions such as benign prostatic hyperplasia (BPH), various kinds of prostatitis, etc., are addressed briefly and prostate adenocarcinoma is discussed in a structured pattern, including the morphological variants, IHC, molecular profiling, microscopic variants, grading, mimickers, etc. Other rare tumors of the prostate are also discussed in brief. This chapter provides a comprehensive update on the 2022 WHO classification of urinary and male genital tumors.

10.5772/intechopen.1006651

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