Zhixiong Yu

Peking University Shenzhen Hospital

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Shuo Lin

Fujian Agriculture and Forestry University

Chao Che

Shenzhen Bay Laboratory

Chuanye Tao

Peking University Shenzhen Hospital

Taofeng Shao

Peking University

Bo Yang

Shenzhen University

Xianlong Jiang

Peking University Shenzhen Hospital

Zhen Yang

Peking University

Shengchang Xin

Nanjing University

Liyan Zhou

Guangxi Medical University

Bo Yang

Kunming University of Science and Technology

Cooperative Institutions

Peking University

Peking University Shenzhen Hospital

Huazhong University of Science and Technology

Beijing National Laboratory for Molecular Sciences

Shanghai Innovative Research Center of Traditional Chinese Medicine

Shenzhen University

Center for Life Sciences

Shenzhen Bay Laboratory

Guangxi Medical University

King University

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One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy

ACS Combinatorial Science (2013)

Chao Che Song Li Zhixiong Yu Fangfang Li Shengchang Xin

One-pot and efficient syntheses of structurally diverse isoquinolin-3-ones and isoquinolin-3-one-based benzo-1,4-diazepin-2,5-diones have been developed. The notable features of the process include the Ugi condensation of monomasked phthalaldehydes with amines, carboxylic acids, and isonitriles, followed by HClO4-mediated intramolecular condensation of the carbonyl with amide.

Amide

Ugi reaction

10.1021/co400001h

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Citations (29)

Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-annulation

The Journal of Organic Chemistry (2013)

Chao Che Bo Yang Xianlong Jiang Taofeng Shao Zhixiong Yu

Diversity-oriented synthesis of fused tetracyclic 6,11-dihydroquinoxalino[2,3-b]quinolines is described via a sequential Ugi-variant multicomponent reaction and Pd-catalyzed bis-annulation in one-pot process.

Annulation

Ugi reaction

10.1021/jo4024792

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Citations (26)

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Beilstein Journal of Organic Chemistry (2012)

Chao Che Li Song Bo Yang Shengchang Xin Zhixiong Yu

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.

10.3762/bjoc.8.94

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Citations (6)

ChemInform Abstract: Syntheses of Fused Tetracyclic Quinolines via Ugi‐Variant MCR and Pd‐Catalyzed Bis‐Annulation.

ChemInform (2014)

Chao Che Bo Yang Xianlong Jiang Taofeng Shao Zhixiong Yu

Abstract A diversity‐oriented synthesis of fused tetracyclic 6,11‐dihydroquinoxalino[2,3‐b]quinolines is described via sequential Ugi‐variant multicomponent reaction and Pd‐catalyzed bis‐annulation in a one‐pot process.

Annulation

10.1002/chin.201423170

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