Tetsuya Okazaki

Institute of Clinical Research

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Kazuhisa Ishi

Juntendo University Urayasu Hospital

Junichi Koyatsu

Social Insurance Saitama Chuo Hospital

Katsunari Kina

Juntendo University

Fujihiko Suzuki

Juntendo University Urayasu Hospital

Claire W. Michael

University Hospitals of Cleveland

Dilip Gupta

Mahatma Gandhi Institute of Medical Sciences

Joel Greif

Tel Aviv Sourasky Medical Center

Ahlam Al‐Juwaiser

Mubarak Al Kabeer Hospital

Mohammad Vasei

Shariati Hospital

Kalpana A. Mahadik

Tata Memorial Hospital

Cooperative Institutions

Juntendo University Urayasu Hospital

Institute of Clinical Research

The University of Texas MD Anderson Cancer Center

The Cancer Institute Hospital

Cornell University

Massachusetts General Hospital

Shiraz University of Medical Sciences

Tata Memorial Hospital

University College of Medical Sciences

University of Delhi

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Acta Cytologica (1999)

Uma Singhal Harsh Mohan Cristina A.T.S. Mitteldorf Antonio Carlos de Oliveira Misiara Iara Emiko de Carvalho

10.1159/000331317

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Cell transfer technique with Malinol mounting medium. An application to immunocytochemistory and ISH methods.

The Journal of the Japanese Society of Clinical Cytology (1996)

Ayako OHONO Katsunari Kina Tetsuya Okazaki Junichi Koyatsu Kazuhisa Ishi

10.5795/jjscc.35.657

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Acta Cytologica (1999)

Uma Singhal Harsh Mohan Cristina A.T.S. Mitteldorf Antonio Carlos de Oliveira Misiara Iara Emiko de Carvalho

10.1159/000331310

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Usefulness of Estrogen Receptor Detection Using Archival Papanicolaou-Stained Smears

Acta Cytologica (1999)

Junichi Koyatsu Kazuhisa Ishi Fujihiko Suzuki Akira Saito Katsunari Kina

To examine estrogen receptor (ER) detection using cytologic specimens and to compare the results with those obtained by the dextran-coated charcoal (DCC) method and enzyme immunoassay (EIA).Immunocytochemical staining was conducted on 60 cases of breast cancer resected at our hospital between April 1993 and November 1997 in which ER had been measured by DCC or EIA. Specimens for immunocytochemical staining were prepared by a cell transfer method using archival Papanicolaou-stained imprint smears, and ER staining was performed by the labeled streptavidin method using an anti-ER monoclonal antibody. These results were compared with those obtained by DCC or EIA.In immunocytochemical staining for ER, positive staining was observed in the nuclei of tumor cells. A good correlation was obtained between the immunocytochemical staining results and biochemical results. Five cases were positive in anti-ER staining but negative in biochemical tests, and two cases were negative in anti-ER staining and positive in biochemical tests.Unlike biochemical assays, the immunocytochemical method does not necessitate use of fresh frozen materials and can be performed even using archival Papanicolaou-stained smears. Immunocytochemical study is a highly useful method for routine ER determination.

10.1159/000331297

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Meaning of cytology in urinary tract neoplasm screening, and NMP22 combined use.

The Journal of the Japanese Society of Clinical Cytology (2003)

Hiroshi Nakamura Kazuhisa Ishi T Furukawa Tetsuya Okazaki Katsunari Kina

目的:現在尿路上皮腫瘍のスクリーニング法としては尿細胞診が広く用いられているが細胞異型の弱い腫瘍の場合には検出感度が低く偽陰性が問題となる. 近年開発された尿中腫瘍マーカーのNMP22は, 迅速に結果が得られ早期の尿路上皮癌を確認できるとされスクリーニングに広く用いられつつある. 今回われわれは, 尿中NMP22値と尿細胞診結果を組織診断および膀胱鏡検査と比較し, 今後の尿路上皮スクリーニング法について検討したので報告する.材料および方法:2000年7月から2002年4月までに当院泌尿器科より提出された外来自然尿675例について尿細胞診およびNMP22 (コニカMatritech UNMP22テストキットELISA法) を比較検討した.結果:臨床的および組織学的に31例の癌 (G1: 8例G2: 19例G3: 4例) が確認された. このうちNMP22では陽性が17例, 細胞診では14例, 陰性はNMP22では14例, 細胞診では17例であった. 細胞診では明らかな偽陽性症例 (+) はみられず, 疑陽性症例 (±) 17例に対しNMP22での偽陽性数は96例であった. これらの要因として細胞診で炎症や結石などにより細胞異型を示していたものがあり, NMP22では白血球成分の多い検体で高値を示していた.考察:今回の検討で尿細胞診では検出感度は低いが特異度が高く診断には欠かせない検査である. 一方, NMP22はG1の癌検出が細胞診に比べ優れているが, 膿尿などの白血球成分の多い検体では偽陽性結果が多く細胞診結果と乖離するためNMP22と尿細胞診との併用が望ましいと思われる.

10.5795/jjscc.42.337

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Citations (1)