Sandra Costa Valle

University of Milan

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Augusto Schneider

Universidade Federal de Pelotas

Carlos Castilho Barros

Universidade Federal de Pelotas

Karla Renata de Oliveira

Universidade Regional do Noroeste do Estado do Rio Grande do Sul

Marcos Luiz Santos Perry

Universidade Federal do Rio Grande do Sul

Luiz Carlos Kucharski

Universidade Federal do Rio Grande do Sul

Juliana dos Santos Vaz

Universidade da Paz

Liane Nanci Rotta

Universidade Federal de Ciências da Saúde de Porto Alegre

Camila Irigonhé Ramos

Ministério da Saúde

ÁG

Álan Gomes Pöppl

Universidade Federal do Rio Grande do Sul

Maria Weber

Medical University of Vienna

Cooperative Institutions

Universidade Federal de Pelotas

Universidade Federal do Rio Grande do Sul

AIDS Clinical Trials Group

Harvard University

University of Rochester

Rush University Medical Center

University of Miami

Office of Infectious Diseases

University of California, Los Angeles

Johns Hopkins University

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Estrus cycle effect on muscle tyrosine kinase activity in bitches

Veterinary Research Communications (2011)

Álan Gomes Pöppl Sandra Costa Valle Félix Hilário Díaz González Carlos Afonso de Castro Beck Luiz Carlos Kucharski

Basal (medicine)

10.1007/s11259-011-9513-7

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Citations (11)

Influência do ciclo estral sobre a sensibilidade à insulina em fêmeas caninas.

Camila Lüdke Rossetti Álan Gomes Pöppl Sandra Costa Valle

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Outcomes by Sex Following Treatment Initiation With Atazanavir Plus Ritonavir or Efavirenz With Abacavir/Lamivudine or Tenofovir/Emtricitabine

Clinical Infectious Diseases (2013)

Kimberly Y. Smith C. Tierney Katie R. Mollan Charles S. Venuto Chakra Budhathoki

Background. We aimed to evaluate treatment responses to atazanavir plus ritonavir (ATV/r) or efavirenz (EFV) in initial antiretroviral regimens among women and men, and determine if treatment outcomes differ by sex. Methods. We performed a randomized trial of open-label ATV/r or EFV combined with abacavir/lamivudine (ABC/3TC) or tenofovir/emtricitabine (TDF/FTC) in 1857 human immunodeficiency virus type 1–infected, treatment-naive persons enrolled between September 2005 and November 2007 at 59 sites in the United States and Puerto Rico. Associations of sex with 3 primary study endpoints of time to virologic failure, safety, and tolerability events were analyzed using Cox proportional hazards models. Model-based population pharmacokinetic analysis was performed using nonlinear mixed effects modeling (NONMEM version VII). Results. Of 1857 participants, 322 were women. Women assigned to ATV/r had a higher risk of virologic failure with either nucleoside reverse transcriptase inhibitor backbone than women assigned to EFV, or men assigned to ATV/r. The effects of ATV/r and EFV upon safety and tolerability risk did not differ significantly by sex. With ABC/3TC, women had a significantly higher (32%) safety risk compared to men; with TDF/FTC, the safety risk was 20% larger for women compared to men, but not statistically significant. Women had slower ATV clearance and higher predose levels of ATV compared to men. Self-reported adherence did not differ significantly by sex. Conclusions. This is the first randomized clinical trial to identify a significantly earlier time to virologic failure in women randomized to ATV/r compared to women randomized to EFV. This finding has important clinical implications given that boosted protease inhibitors are often favored over EFV in women of childbearing potential. Clinical Trials Registration NCT00118898.

Efavirenz

Abacavir

Emtricitabine

Atazanavir

Ritonavir

Tenofovir

10.1093/cid/cit747

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Citations (32)

Combination of ACTN3 R577X and ACE I/D polymorphisms as a tool for prediction of obesity risk in children

International Journal of Obesity (2020)

Patrícia Britto Costa Laura C.R. Aranalde Poliana Espíndola Correia Guilherme R. F. Cardozo Evelise Sampaio da Silva

Buccal swab

10.1038/s41366-020-00668-3

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Citations (9)

Increased monocytes are associated with overweight in children and adolescents with autism spectrum disorder

Nutrición Hospitalaria (2023)

Bárbara Peter Gonçalves Eduarda de Souza Silva Josiane da Cunha Luçardo Mayra Pacheco Fernandes Kamila Castro Grokoski

Objective: to investigate the monocyte count and its association with nutritional status in children and adolescents with autism spectrum disorder (ASD). Methods: a cross-sectional study carried out at a Neurodevelopmental Center in the south of Brazil, with 68 ASD patients aged 3 to 18 years. The number of monocytes (per mm3) was determined in blood samples. Nutritional status was defined as BMI-for-age according to WHO standards. The Children's Eating Behaviour Questionnaire and a standard questionnaire to collect sociodemographic and clinical characteristics were administered to caregivers. Comparisons between sociodemographic, clinical, and eating behavior variables were performed with parametric tests. Linear regression was used to test the association between nutritional status and monocyte count. Results: mean age was 8.6 ± 3.3 years, 79 % were males and 66 % were overweight. In the unadjusted regression overweight was associated with higher monocyte counts compared to those non-overweight (B: 64.0; 95 % CI, 13.9 to 114.1; β: 0.30, p = 0.01). This association remained significant after adjustment for the subscale of "emotional overeating" (B: 37.0; 95 % CI, 17.1 to 91.3; β: 0.29; p = 0.02). The variability in monocyte count attributed to overweight was 14 %. Conclusions: overweight is associated with a higher monocyte count in children and adolescents with ASD. Nutritional intervention to control overweight is essential to mitigate the negative impact on inflammatory activity and immune dysfunction in these patients.Objetivo: investigar el recuento de monocitos y su asociación con el estado nutricional en niños y adolescentes con trastorno del espectro autista (TEA). Método: estudio transversal realizado en el Centro de Neurodesarrollo, en el sur de Brasil, con 68 pacientes con TEA de 3 a 18 años de edad. Se determinó el número de monocitos (por mm3) en muestras de sangre. El estado nutricional se definió como IMC para la edad según los estándares de la OMS. Se aplicó a los cuidadores el Cuestionario de Conducta Alimentaria Infantil y un cuestionario estándar para recoger características sociodemográficas y clínicas. Las comparaciones entre las variables sociodemográficas, clínicas y de conducta alimentaria se realizaron con pruebas paramétricas. Se utilizó la regresión lineal para probar la asociación entre el estado nutricional y el recuento de monocitos. Resultados: la edad media fue de 8,6 ± 3,3 años, el 79 % eran varones y el 66 % tenían sobrepeso. En la regresión no ajustada, el sobrepeso se asoció a un mayor número de monocitos en comparación con los que no tenían sobrepeso (B: 64,0; IC 95 %: 13,9 a 114,1; β: 0,30; p = 0,01). Esta asociación siguió siendo significativa tras ajustar la subescala de "sobrealimentación emocional" (B: 37,0; IC 95 %: 17,1 a 91,3; β: 0,29; p = 0,02). La variabilidad en el recuento de monocitos atribuida al sobrepeso fue del 14 %. Conclusiones: el sobrepeso se asocia a un mayor recuento de monocitos en niños y adolescentes con TEA. La intervención nutricional para controlar el sobrepeso es esencial para mitigar el impacto negativo sobre la actividad inflamatoria y la disfunción inmune en estos pacientes.

Overeating

Cross-sectional study

10.20960/nh.04472

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Citations (1)

Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake

Archives of Endocrinology and Metabolism (2019)

Mauren Castro Ritta Aline Marques Baldez Isabel Oliveira Driele N. Garcia Paola Spiering Souza

The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile.A cross-sectional study with female patients aged between 35 and 59 years old was conducted. Women were divided into two groups: premenopausal (n = 40) and postmenopausal (n = 36). Women enrolled in the study had serum PON1, total cholesterol, HDL, LDL, glucose and HbA1c, as well as the BMI measured. Additionally, women were genotyped for the PON1 T(-107)C polymorphism and the food intake profile was obtained through interview.Glucose (p = 0.03), HbA1c (p = 0.002) and total cholesterol (p = 0.002)concentrations were higher in post than premenopausal women, however PON1 activity was not different (p > 0.05). Carriers of the C allele had higher PON1 activity (CC: 88.9 ± 6.5 U/mL and CT: 79.9 ± 4.7 U/mL) than women of the TT genotype (66.6 ± 5.9 U/mL) (p < 0.05). However, the model predicting PON1 activity was slightly better when genotype, total fat and cholesterol content in the diet were all included.In sum, we observed that the PON1 C(-107)T genotype was the major regulator of PON1 activity, and menopause had no effect on PON1 activity. The lipid and glycemic profile were altered in postmenopausal women.

Paraoxonase

Aryldialkylphosphatase

Lipid Profile

10.20945/2359-3997000000130

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Citations (4)

Receptor insulin-like e transporte de nutrientes energéticos em Neohelice granulata : sazonalidade

Sandra Costa Valle

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Pyometra-associated insulin resistance assessment by insulin binding assay and tyrosine kinase activity evaluation in canine muscle tissue

Domestic Animal Endocrinology (2021)

Álan Gomes Pöppl Sandra Costa Valle T.S. Mottin Juliano S. Leal Félix Hilário Díaz González

Pyometra

Basal (medicine)

10.1016/j.domaniend.2021.106626

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Citations (5)

Ontogenetic study of the effects of energetic nutrients on amino acid metabolism of rat cerebral cortex.

Neurochemical Research (2002)

Karla Renata de Oliveira Liane Nanci Rotta Sandra Costa Valle Diogo André Pilger Cristina W. Nogueira

Carbohydrate Metabolism

10.1023/a:1019804804592

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Citations (4)

Insulin binding characteristics in canine muscle tissue: effects of the estrous cycle phases

Pesquisa Veterinária Brasileira (2016)

Álan Gomes Pöppl Sandra Costa Valle Félix Hilário Díaz González Luiz Carlos Kucharski Roselis S.M. da Silva

Abstract: Hormonal fluctuations during the different estrous cycle are a well-recognized cause of insulin resistance in bitches, and little is known about insulin receptor binding or post-binding defects associated with insulin resistance in dogs. To evaluate insulin binding characteristics in muscle tissue of bitches during the estrous cycle, 17 owned bitches were used in the study (six in anestrus, five in estrus, and six in diestrus). An intravenous glucose tolerance test (IVGTT) was performed in all patients by means of injection of 1mL/kg of a glucose 50% solution (500mg/kg), with blood sample collection for glucose determination at 0, 3, 5, 7, 15, 30, 45 and 60 minutes after glucose infusion. Muscle samples, taken after spaying surgery, were immediately frozen in liquid nitrogen and then stored at -80 ºC until the membranes were prepared by sequential centrifugation after being homogenized. For binding studies, membranes were incubated in the presence of 20,000cpm of human 125I-insulin and in increasing concentrations of unlabeled human regular insulin for cold saturation. The IVGTT showed no differences among bitches during the estrous cycle regarding baseline glycemia or glycemic response after glucose infusion. Two insulin binding sites - high-affinity and low-affinity ones - were detected by Scatchard analysis, and significant statistical differences were observed in the dissociation constant (Kd1) and maximum binding capacity (Bmax1) of the high-affinity binding sites. The Kd1 for the anestrus group (6.54±2.77nM/mg of protein) was smaller (P<0.001) than for the estrus (28.54±6.94nM/mg of protein) and diestrus (15.56±3.88nM/mg of protein) groups. Bmax1 in the estrus (0.83±0.42nM/mg of protein) and diestrus (1.24±0.24nM/mg of protein) groups were also higher (P<0.001) than the values observed in anestrus (0.35±0.06nM/mg of protein). These results indicate modulation of insulin binding characteristics during different phases of the estrous cycle in dogs, showing that muscle insulin binding affinity for its receptor is reduced during estrus and diestrus. However, this poor hormone-receptor affinity is compensated for by a greater total binding capacity, once there is no difference in patients' glycemic response after an intravenous glucose load.

10.1590/s0100-736x2016000800014

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Citations (4)