Zhida Sun

China Animal Disease Control Center

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Bijun Xie

Huazhong Agricultural University

Shuyi Li

Wuhan Polytechnic University

Qian Wu

Hubei University of Technology

Yong Sui

Ministry of Agriculture and Rural Affairs

Yashu Chen

Oil Crops Research Institute

Juan Xiao

Hainan University

Ruifen Zhang

Guangdong Academy of Agricultural Sciences

Kai Hu

Northwest A&F University

Qianchun Deng

Oil Crops Research Institute

Lihong Dong

Ministry of Agriculture and Rural Affairs

Cooperative Institutions

Huazhong Agricultural University

Ministry of Agriculture and Rural Affairs

Chinese Academy of Agricultural Sciences

Chinese Academy of Sciences

Oil Crops Research Institute

Huazhong University of Science and Technology

Guangdong Academy of Agricultural Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

Hubei University of Technology

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Identification of A-series oligomeric procyanidins from pericarp of Litchi chinensis by FT-ICR-MS and LC-MS

Food Chemistry (2012)

Shuyi Li Juan Xiao Lu Chen Chonglin Hu Peng Chen

Trimer

10.1016/j.foodchem.2012.04.039

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Citations (88)

Rapid Preparation of Procyanidins B2 and C1 from Granny Smith Apples by Using Low Pressure Column Chromatography and Identification of Their Oligomeric Procyanidins

Journal of Agricultural and Food Chemistry (2008)

Junsong Xiao Liang Liu Hua Wu Bijun Xie Yang Er-ning

Research in the field of procyanidins is always hindered by the lack of procyanidin standards, and the preparation of procyanidins, especially in large scale, remains difficult and time-consuming. Commercial sources of procyanidin standards are scarce. In this study, a rapid preparation method of procyanidins by using low-pressure column chromatography was developed. Procyanidins in Granny Smith apples were extracted with boiled water and purified on an ADS-17 macroporous resin column to obtain a Granny Smith apple procyanidin extract (GSE). GSE was fractionated according to its degree of polymerization on a Toyopearl TSK HW-40s column. Procyanidins B2 (epicatechin-(4beta-8)-epicatechin) and C1 (epicatechin-(4beta-8)-epicatechin-(4beta-8)-epicatechin) were prepared without HPLC separation. Oligomeric procyanidins from Granny Smith apples were also identified by liquid chromatography-electrospray ionization-mass spectrometry.

10.1021/jf072679x

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Citations (26)

Inhibitory effects of lotus seedpod procyanidins against lipid and protein oxidation and spoilage organisms in chilled-storage beef

LWT (2022)

Li Xin Jingyi Wang Xueqin Gao Bijun Xie Zhida Sun

Oxidation of lipids and proteins, as well as microbial spoilage, are the main causes of impaired sensorial, nutritional and edible qualities of chilled beef during storage. Therefore, this study investigated the effects of lotus seedpod procyanidins (LSPC) on the quality of chilled beef during refrigerated storage. After 17 days of storage, spraying LSPC (0.25, 0.5, 0.75 g/L) not only inhibited the oxidation of lipids (thiobarbituric acid-reactive substances and conjugated dienes content in 0.75 g/L LSPC group reduced by 45.92% and 17.51%, respectively, compared with the control group), but its protein oxidation was also weakened (carbonyl contents reduced by 23.12%, sulfydryl content increased by 69.17% in 0.75 g/L LSPC group, respectively, compared with the control group), and the mechanism may involve inhibition of the formation of CO bonds and maintenance of the ordered structure of myofibrillar protein in chilled beef treated with LSPC. Moreover, LSPC-treated beef had lower total viable counts (TVC) and Pseudomonas than beef treated with sodium erythorbate. Additionally, the physicochemical characteristics of chilled beef were improved through LSPC treatments, and its shelf life was extended by 4–8 days. Thus, this study demonstrated that LSPC is an effective natural dual-functional antioxidant and antimicrobial preservative for chilled beef.

Lipid Oxidation

Food Preservation

10.1016/j.lwt.2022.113247

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Citations (16)

In Vitro Human Gut Microbiota Fermentation of Litchi Pulp Polysaccharides as Affected by Lactobacillus Pre-Treatment

Chunmei Xia Ruifen Zhang Xuchao Jia Lihong Dong Qin Ma

In this study, litchi polysaccharides were obtained from unfermented or fermented pulp by Lactobacillus fermentum (denoted as LP and LPF, respectively). The differences between LP and LPF in the colonic fermentation characteristics and modulatory of gut microbiota growth and metabolism were investigated with an in vitro fecal fermentation model. Results revealed that the strategies of gut bacteria metabolizing LP and LPF were different and LPF with lower Mw was readily utilized by bacteria. The monosaccharide utilization sequence of each polysaccharide was Ara > Gla > GalA > GlcA ≈ Glu ≈ Man. Moreover, LPF promoted stronger proliferation of Bifidobacterium, Megamonas, Prevotella, and Bacteroides and higher SCFAs production (especially acetic and butyric acids) than LP. Correlation analysis further revealed that Mw could represent an essential structural feature of polysaccharides associated with its microbiota-regulating effect. Overall, Lactobacillus fermentation pre-treatment of litchi pulp promoted the fermentation characteristics and prebiotic activities of its polysaccharide.

10.2139/ssrn.4679620

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Inhibitory effect of lotus seedpod oligomeric procyanidins on advanced glycation end product formation in a lactose–lysine model system

Electronic Journal of Biotechnology (2014)

Qian Wu Shuyi Li Ting Yang Juan Xiao Qian-Mei Chu

Industrial food processing induces protein glycation modifications and toxic advanced glycation end products (AGEs) which affect human health. Therefore, it is of interest to monitor AGEs in food processing. The present study was carried out to investigate the influence of lotus seedpod oligomeric procyanidin (LSOPC) concentrations, solution pH value and metal ions on AGE formation by heat treatment of lactose–lysine model solutions. Nε-(carboxymethyl) lysine (CML), as one of the common AGEs was also determined by HPLC–MS/MS in this experiment. The results showed that LSOPC can inhibit the formation of AGEs effectively at higher concentrations, lower temperature, and it can reverse the promotion function of metal ions because of its high inhibition activity. Also, LSOPC can inhibit CML formation in the Maillard reaction as well. These results indicated that LSOPC could be used as functional food ingredients to inhibit AGE formation.

Advanced glycation end-product

Functional food

10.1016/j.ejbt.2014.10.005

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Citations (24)

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

Molecules (2020)

Yashu Chen Fenghong Huang David Julian McClements Bijun Xie Zhida Sun

The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation.

Phototoxicity

Dermal fibroblast

Photoaging

Hydroxyproline

Human skin

10.3390/molecules25061458

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Citations (16)

Quality parameters and bioactive compound bioaccessibility changes in probiotics fermented mango juice using ultraviolet-assisted ultrasonic pre-treatment during cold storage

LWT (2020)

Jingyi Wang Bijun Xie Zhida Sun

Carrot juice

10.1016/j.lwt.2020.110438

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Citations (54)

(−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice

Food & Function (2018)

Xiaopeng Li Shuyi Li Mo Chen Jingyi Wang Bijun Xie

As a major component of green tea, (-)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists owing to its potential to combat a variety of human diseases including abnormal glucose metabolism in obesity and diabetes. This study aims to (1) evaluate the molecular mechanism of EGCG in starch digestion before EGCG absorption; (2) investigate the link between PXR/CAR-mediated phase II metabolism and glucose homeostasis after EGCG is transported to small intestine and liver. EGCG suppressed starch hydrolysis both in vitro and in vivo. Molecular simulation results demonstrated that EGCG could bind to the active site of α-amylase and α-glucosidase, acting as an inhibitor. In addition, the anti-diabetic action of EGCG was investigated in high fat diet and STZ-induced type 2 diabetes. EGCG improved glucose homeostasis and inhibited the process of gluconeogenesis (PEPCK and G-6-Pase) and lipogenesis (SREBP-1C, FAS and ACC1) in the liver. Meanwhile, EGCG treatment activated PXR/CAR, accompanied by upgrading PXR/CAR-mediated phase II drug metabolism enzyme expression in small intestine and liver, involving SULT1A1, UGT1A1 and SULT2B1b. Dietary polyphenol EGCG could serve as a promising PXR/CAR activator and therapeutic intervention in diabetes.

Pregnane X receptor

Carbohydrate Metabolism

Digestion

Homeostasis

Gallate

10.1039/c8fo01293h

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Citations (84)

Distribution and activity rhythm of small Indian civet (<i>Viverricula indica</i>) in Fenghuang Hill and Qi’ao Island, Zhuhai, Guangdong

Biodiversity Science (2024)

Xiang Gao Sharon Pan Zhida Sun Jixiao Li Ting Gao

10.17520/biods.2024045