Luciano Cellai

Istituto di Metodologie Chimiche

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M. Brufani

Universidade da Coruña

Cecilia Bartolucci

National Research Council

S. Cerrini

Istituto di Metodologie Chimiche

Mario Brufani

Sapienza University of Rome

Doriano Lamba

Institute of Crystallography

W. Fedeli

Sapienza University of Rome

Emanuele Perola

Blueprint Medicines (United States)

Anna Laura Segre

National Research Council - Institute of Methodologies for Environmental Analysis

A. Benedetto

IRCCS San Camillo Hospital

G. Andreano

Institute of Crystallography

Cooperative Institutions

Istituto di Metodologie Chimiche

Sapienza University of Rome

National Research Council

University of Siena

Istituto di Chimica Biomolecolare

Istituto Superiore di Sanità

Centre National de la Recherche Scientifique

National Academies of Sciences, Engineering, and Medicine

University of Padua

Institute of Crystallography

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X‐Ray Crystal Structure of 25‐O‐Deacetyl‐27, 28‐didehydro‐27‐demthoxy‐11‐deoxo‐11, 29‐epoxy‐28,29‐dihydro‐21,23‐O‐isopropylidenerifamycin S

Helvetica Chimica Acta (1992)

Cecillia Bartolucci Luciano Cellai S. Cerrini Patrizia Di Filippo Doriano Lamba

Abstract In search of new types of semisynthetic derivatives of the natural antibiotic rifamycin S ( 1 ), we synthesized 25‐ O ‐deacetyl‐27,28‐didehydro‐27‐demethoxy‐11‐deoxo‐11,29‐epoxy‐28, 29‐dihydro‐21,23‐ O ‐isopropyli‐denerifamycin S ( 3 ). Its X‐ray crystal structure shows a new type of ansa ‐chain with an 11,29‐epoxy moiety, the loss of the MeO group on C(27), and the shift of the CC bond from C(28),C(29) to C(27),C(28). These modifications result in a conformational rearrangement of the whole ansa ‐chain, nonetheless the overall spatial shape of the molecule is still close to that of most rifamycins. As found in other 11‐deoxo‐11‐hydroxyrifamycin‐S derivatives, the chromophore rings of 3 give rise to π‐π association in the crystal.

Moiety

Chromophore

10.1002/hlca.19920750112

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Citations (3)

NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription.

Journal of Biomolecular NMR (1999)

Thomas Szyperski Matthias Götte Martin Billeter Emanuele Perola Luciano Cellai

RNase H

Duplex (building)

Nucleic acid structure

10.1023/a:1008350604637

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Citations (39)

ChemInform Abstract: Quinolinehydrazones, e.g. (I) and (II), as Inhibitors of Retroviral Reverse Transcriptase.

ChemInform (1994)

Cecilia Bartolucci Luciano Cellai Patrizia Di Filippo Vittorio Brizzi Cesare Pellerano

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199408208

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3-(Carboxyalkylthio) rifamycin S and SV derivatives inhibit human neutrophil functions.

Inflammation (1998)

Susanna Spisani Serena Traniello Alberto Mochi Onori Olivia Rizzuti Concetta Martuccio

Rifamycin

10.1023/a:1022341909396

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Citations (14)

Preparation of Spin-Labeled-2-Amino-dA, dA, dC and 5-Methyl-dC Phosphoramidites for the Automatic Synthesis of EPR Active Oligonucleotides

Synthesis (2001)

Cesare Giordano Federica Fratini Donato Attanasio Luciano Cellai

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (TEMPO) labeled phosphoramidites of 2-amino-dA, dA, dC and 5-methyl-dC were synthesized and used for the automatic synthesis of mono-labeled oligodeoxynucleotides (ODNs), which proved active to EPR. It is now possible to insert a paramagnetic probe into nucleic acids in a site- and type-specific manner. The combination of this synthetic approach with EPR spectroscopy can be exploited for performing studies on dynamics and local structural modifications in nucleic acids.

Site-directed spin labeling

10.1055/s-2001-12355

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Citations (24)

SnO<inf>2</inf> nanowire bio-transistor for electrical DNA sensing

IEEE Sensors (2007)

C. Baratto Silvia Todros Elisabetta Comini G. Faglia Matteo Ferroni

An innovative JFET bio-transistor, based on a metal oxide (MOX) nanowire bundle, was developed in order to electrically detect biological binding. The working principle of this device relies on modulation of a MOX space charge region (SCR), acting as the channel of a field effect transistor, instead of an enriched/depleted Si channel like in chem.-FETs. The feasibility was at first demonstrated by the development of a bio-sensor made of an SnO ₂ thin film derivatized with oligodeoxyribonucleotide-probes. We implemented a protocol to immobilize single strands of nucleic acid over SnO ₂ and developed a system for electrical sensing of hybridization in liquid solution. The same protocol was then applied on a SnO ₂ nanowire bundle, synthesized by thermal evaporation of oxide powders under controlled conditions with the presence of Pt catalyst. The results obtained on a group of nanowires suggest the possibility -now under development -to produce nano-bio-transistors based on single nanowires of metal oxides.

10.1109/icsens.2007.4388606

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Citations (2)

Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1.

PubMed (1992)

Cecilia Bartolucci Luciano Cellai Patrizia Di Filippo Anna Laura Segre M. Brufani

Reverse-transcriptase inhibitor

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Citations (12)

ChemInform Abstract: 4‐Deoxypyrido[1′,2′:1,2]imidazo[5,4‐;c]rifamycin SV Derivatives. A New Series of Semisynthetic Rifamycins with High Antibacterial Activity and Low Gastroenteric Absorption.

Chemischer Informationsdienst (1985)

Egidio Marchi L. Montecchi Arianna Venturini Giuseppe Mascellani M. Brufani

Abstract Die Verbindungen (I), deren Synthese beschrieben wird, sind antibakteriell hochwirksam.

Rifamycin

10.1002/chin.198544331

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Citations (0)

ChemInform Abstract: X‐Ray Crystal Structure of 25‐O‐Deacetyl‐27,28‐didehydro‐27‐demethoxy‐ 11‐deoxo‐11,29‐epoxy‐28,29‐dihydro‐21,23‐O‐isopropylidenerifamycin S

ChemInform (1992)

Cecilia Bartolucci Luciano Cellai S. Cerrini Patrizia Di Filippo Doriano Lamba

10.1002/chin.199217300

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Citations (1)

Tetra-2,3-pyrazinoporphyrazines with Externally Appended Pyridine Rings. 10. A Water-Soluble Bimetallic (Zn^II/Pt^II) Porphyrazine Hexacation as Potential Plurimodal Agent for Cancer Therapy: Exploring the Behavior as Ligand of Telomeric DNA G-Quadruplex Structures

Inorganic Chemistry (2011)

Ilse Manet Francesco Manoli Maria Pia Donzello Claudio Ercolani Daniela Vittori

The behavior of a bimetallic water-soluble (Zn(II)/Pt(II)) porphyrazine hexacation as ligand of G-quadruplex (G4) structures adopted by a human telomeric DNA sequence has been examined with different spectroscopic techniques. In K(+) rich solution the hexacationic Zn(II) porphyrazine ligand bearing a peripheral cis-platin-like functionality changes the G-quadruplex conformational equilibrium of the human telomeric sequence 5'-d[AGGG(TTAGGG)(3)]-3' and drives it exclusively toward a very stable parallel G4 form in the complex with 2:1 stoichiometry. An increase of the melting temperature of more than 20 °C is observed in this complex compared to the G4 alone. On the contrary ligand binding to G-quadruplex of the same telomeric sequence in Na(+) rich solution neither markedly influences the predominant basket conformation nor confers increased thermal stability to the G4 structure.

Porphyrazine

Tetra

Bimetallic strip

Trifluoromethanesulfonate

10.1021/ic200514z

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Citations (25)