Sharmin Jahan

Bangabandhu Sheikh Mujib Medical University

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Muhammad Abul Hasanat

Bangabandhu Sheikh Mujib Medical University

Nusrat Sultana

Okayama University

M Fariduddin

Institute of Medical Sciences

Mashfiqul Hasan

Bangabandhu Sheikh Mujib Medical University

Tania Tofail

Bangabandhu Sheikh Mujib Medical University

Marufa Mustari

Bangabandhu Sheikh Mujib Medical University

Hurjahan Banu

Bangabandhu Sheikh Mujib Medical University

Md Fariduddin

Bangabandhu Sheikh Mujib Medical University

Shahjada Selim

Bangabandhu Sheikh Mujib Medical University

Tahniyah Haq

Bangabandhu Sheikh Mujib Medical University

Cooperative Institutions

Bangabandhu Sheikh Mujib Medical University

Dhaka Medical College and Hospital

University of Dhaka

Shanghai Jiao Tong University

National Institute of Neurosciences & Hospital

Noakhali Science and Technology University

Directorate General of Health Services

National Institute of Cardiovascular Diseases

Bangladesh Council of Scientific and Industrial Research

Jahangirnagar University

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Petroleum Ether and Chloroform Soluble Fractions of Whole Plant Extract of Acanthus ilicifolis Linn. Possesses Potential Analgesic and Antioxidant Activities.

Discovery Phytomedicine - Journal of Natural Products Research and Ethnopharmacology (2020)

Md. Abu Rayhan Faisal Md Abdul Barek Sharmin Jahan A. F. M. Shahid-Ud-Daula Mohammad Anwarul Basher

Background: Medicinal plants are the major sources of traditional treatment of disease and new drug discovery due to major side effects of synthetic drug. Objectives: The aim of study was to evaluate analgesic and antioxidant activities of petroleum ether and chloroform soluble fractions of whole plant extract of Acanthus ilicifoius. Materials and Methods: The plant extract, standard diclofenac, and distilled water as control was administered post orally in Swiss albino mice and observe the analgesic activity by acetic acid (0.6%) induced writhing method. The plant extract was also subjected to perform reducing power assay, DPPH free radical scavenging activity, and FRAP assay to evaluate antioxidant activity. Results: The pet ether, and chloroform soluble fraction of plant extract revealed significant analgesic activity on mice model. Notably, the pet ether and chloroform fraction showed (40.14 Â± 2.32) % and (40.12 Â± 0.9) % analgesic inhibition, whereas standard diclofenac revealed (52.79 Â± 2.62) % analgesic inhibition. In antioxidant activity assay, the plant extract showed mild to moderate antioxidant activities compare to standard ascorbic acid. Conclusion: From the results, it could be concluded that, the pet ether and chloroform fractions of whole plant extract of A. ilicifolius possesses potential analgesic and antioxidant properties.

Petroleum ether

10.15562/phytomedicine.2020.113

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Relative evaluation of in-vitro antioxidant potential and phenolic constituents by HPLC-DAD of Brassica vegetables extracted in different solvents

Heliyon (2022)

Mohammad Mahfuzur Rahman Abu Tareq Mohammad Abdullah Miskat Sharif Sharmin Jahan Md. Alamgir Kabir

Cabbage, cauliflower and broccoli are well-known vegetables from the Brassica family having functional effects on human health. This study was carried out to identify different antioxidant properties and to quantify phenolic compounds by HPLC-DAD in different extracts (methanol, ethanol and water: acetic acid: acetone) of these vegetables. The results showed that, the methanolic dry extract of cabbage possessed the highest antioxidant activity (549 ± 7.30 μg/g) and IC50 was 90 ± 2.52 μg/mL than others. Whereas the ethanolic dry extract of cauliflower had 348 ± 5.20 μg/g of flavonoid, which was the highest among all. The maximum levels of total tannin (414 ± 5.20 μg/g) and total phenolic content (465 ± 3.25 μg/g) was found in broccoli dry extract. Several polyphenolic compounds were identified in different extracts of the vegetables and they were Cauliflower (8) > Cabbage (10) > Broccoli (9) in total. Therefore, the use of total vegetables rather than extracts in the food industry would be more appropriate to get greater health benefit.

Tannin

10.1016/j.heliyon.2022.e10838

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The view of recent medical graduates on ethical consideration of prescription writings in Bangladesh

Bangladesh Journal of Medical Education (2021)

Sharmin Jahan Meerjady Sabrina Flora

Prescription writing reflects the competency as well as the quality of medical education of the physician. This study was done to evaluate opinion of recent medical graduates towards ethical aspects of prescription writing. This descriptive study was conducted on recent medical graduates of 7 medical colleges in Bangladesh from January’18-June’19. Data were collected by a pretested self administered semi-structured questionnaire. Only descriptive statistics were computed by collected data. The study included 308 recent medical graduates having average age at commencement of internship was 24.2 years with male predominant (53.2%). Majority of the respondents thought that prescription should be written in block letter or be printed (70.1%) and there was possibility for selling wrong medicine due to bad handwriting (77.6%). Majority of the recent medical graduates thought that generic names were not difficult to remember (82.8%), there was every possibility of selling poor quality drugs of the same generic names by the pharmacists (87.7%) and physicians should not use generic name in prescriptions (56.5%). Furthermore, most of them (92%) felt a need for a mandatory educational qualification for the pharmacists. Most participants opined that pharmacists should have a minimum educational qualification to prevent the errors in dispensing. The findings of this study might be helpful to reinforcement the law to avoid the errors related to medical professionalism and ethical aspects of prescription writing in the medical education. Bangladesh Journal of Medical Education Vol.12(1) 2021: 16-21

Handwriting

10.3329/bjme.v12i1.52305

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Knowledge of recent medical graduates and views of stakeholders and teachers regarding medical ethics and professionalism in Bangladesh

Bangladesh Journal of Medical Education (2022)

Sharmin Jahan MS Flora

Medical education aims to produce competent medical professionals and gives emphasis on competency-based learning in Bangladesh. Medical ethics and professionalism are considered as a core competency. A competent physician can ensure patient-centered health care system. This was an effort to obtain data regarding the knowledge of recent medical graduates and the opinion of medical educational stakeholders and teachers about medical ethics and professionalism at undergraduate medical education in Bangladesh. This mixed-method study was conducted in two rounds. The Round I was conducted from January 2018 to June 2019 for assessing the knowledge of 308 recent medical graduates towards medical ethics and professionalism. In Round II, key informant interviews were conducted among 30 medical educational stakeholders and teachers from July 2020 to December 2020. Data were collected by pre-tested self administered semi-structured questionnaire and interview guidelines. The percentages of recent medical graduates who could give correct answers regarding autonomy, justice, presenting a subject to visual social media, breaching of confidentiality, organ donation and medical certificate were 19.8%, 54.9%, 73.1%, 37.3%, 91.6% and 74.4% respectively. Most of the medical educational stakeholders and teachers (80%) expressed their opinion related to curriculum. They also suggested for practicing ethics (20.0%) and training (20.0%). A gap was observed in the knowledge regarding medical ethics and professionalism of recent medical graduates. To improve practice of ethics and professionalism, enhancement of the knowledge by incorporating “medical ethics and professionalism” in curriculum might be considered. A separate compulsory module for training on medical ethics and professionalism can be added at pre-internship period for the recent medical graduates. Bangladesh Journal of Medical Education Vol.13(1) January 2022: 40-48

10.3329/bjme.v13i1.57505

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Abstract #405: A Young Boy with Xanthoma – A Rare Case of Hypercholesterolemia

Endocrine Practice (2017)

Marufa Mustari Mohammed K. Alam Tahniyah Haq Sharmin Jahan Muhammad Abul Hasanat

Xanthoma

10.1016/s1530-891x(20)44438-6

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Hyperlipidemia in childhood idiopathic nephrotic syndrome during initial remission and relapse.

PubMed (2011)

Salaheddin M. Mahmud Sharmin Jahan M M Hossain

The objective of this study was to correlate hyperlipidemia during initial remission of nephrotic child with relapse. This observational prospective study was carried out among 26 children, between 1 to 8 years age with first attack idiopathic nephrotic syndrome, who was seen at Paediatric Nephrology Department of BSMMU and Paediatric Nephrology Department, NIKDU, from December'2005 to August'2006 and were followed-up for at least 6 months after initial attack. Twenty two age and sex matched hospitalized children, suffering from non-renal diseases, were enrolled as controls. Fasting blood samples for lipid profile were taken at the time of diagnosis of both cases and controls and also during remission of cases only. These patients were divided into two groups based on serum lipid profile during remission. Group-I consisted 16 patients who had normal lipid profile during remission and Group-II consisted 10 patients who had abnormal lipid profile during remission. Both Groups I & II had higher mean levels of serum cholesterol, LDL, TG and Lp(a) than those of controls during initial diagnosis. Between two groups on remission, Group-II patients showed higher mean serum cholesterol (332.9±105.19 mg/dL vs. 183.13±16.89 mg/dL; p<0.001), serum LDL (252±101.67 mg/dL vs. 119.19±21.33mg/dL; p<0.001), and serum TG (182.8±73.83 mg/dL vs. 93.31±20.95 mg/dL; p<0.001). Five patients out of 10 patients of Group-II (19% of total case) developed subsequent relapse within 6 months follow-up. Among the relapsers, mean cholesterol (334±46 vs. 232±34 mg/dL; p<0.05) was significantly higher than that of non-relapsers of Group-II patients. On the other hand, no patient of Group-I developed relapse within 6 months follow-up. It may be concluded from this study that hyperlipidemia in general at remission, specifically serum total cholesterol, may be regarded as predictor of relapse in childhood idiopathic nephrotic syndrome.

Hyperlipidemia

Nephrology

Lipid Profile

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Alarming Frequency of Gestational Diabetes Mellitus (GDM) Attending a Tertiary Care Hospital in Bangladesh

Urman Dhruv Om Prakash Gupta Nusrat Sultana Hasanat MA Sharmin Jahan

Tertiary care

10.12345/jcd.2016.2.4.1

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Respiratory Failure? What to Do in Duchenne's Muscular Dystrophy Patients

S. Hossain Randhir Jesudoss Ethel Patten Sharmin Jahan

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5849

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Dealing of 100 Cases of Mastalgia at Sadar Hospital, Laxmipur

Sharmin Jahan Most. Nasrin Jahan

Introduction Introduction: Mastalgia is a common and painful experience among women,adversely affecting daily life by reducing the quality of life and yielding to anxiety. The purposeof the present study was to find out the related factor that cause mastalgia and its relation withbenign or malignant breast disease. Methods This study was carried out in OPD (outpatient department) of surgery at SadarHospital, Laxmipur from January 2018 to June 2019. About 100 cases were selected from OPDof surgery with pain in the breast. It was prospective type of observational study. All patientenrolled into the study underwent a standard survey via Questionnaire. Physical examinationwas carried out in all patients. Ultrasonography and mammography were done when necessaryto exclude benign disease or occult malignancy. After taking informed consent about to theresponse of treatment of patient and follow up of patients were scheduled at 4, 8 and 16 weeks.Mastalgia severity and effect on daily life, sleep patterns, and sexuality were evaluated with theaid of a visual analogue scale graded from 0 to 10. Results Age distribution of the study was 30 -50 years, mean 40 years. We had found somerelated factor that cause increase breast pain like age of patient, emotional stress level,consumption of caffeine/tea, smoking, number of pregnancy and breast feeding, weight ofpatient and the presence of any recent trauma to the breast, pre-menopausal syndrome, benignbreast disease like fibrocystic disease, cyst, fibroadenoma etc. and its relationship to themenstrual cycle or not. In this study about 70% of the patients treated with reassurance,wearing appropriate bra and daily life style changes like weight loss, stop smoking and use mildanalgesia like (acetaminophen).Conclusion Most of the mastalgia patient can be managed by reassurance and good brasupport without further intervention.

Outpatient clinic

Breast disease

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METHANOLIC EXTRACT OF AERIAL PARTS OF RAPHANUS SATIVUS VAR. HORTENSIS SHOWS ANTIHYPERGLYCEMIC AND ANTINOCICEPTIVE POTENTIAL

World Journal of Pharmacy and Pharmaceutical Sciences (2014)

Sharmin Jahan Mohammed Rahmatullah Dong‐Gyu Jo

Background. Raphanus sativus var. hortensis is a popular vegetable in Bangladesh with roots and aerial parts of the plant forming the edible portions. The objective of this study was to analyze the antihyperglycemic and antinociceptive properties of methanol extract of aerial parts of the plant. Methods. Antihyperglycemic activity was determined through oral glucose tolerance tests (OGTT). Antinociceptive activity was determined by observed decreases in abdominal constrictions (writhings) in intraperitoneally administered acetic acid-induced pain model in mice. Results. Administration of methanol extract of aerial parts led to dose-dependent reductions in blood glucose levels in glucose-loaded mice. At doses of 100, 200 and 400 mg per kg body weight, the extract significantly reduced blood glucose levels by 21.4, 28.6, and 51.5%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 47.3%. In antinociceptive activity tests, the extract at doses of 50, 100, 200 and 400 mg per kg body weight reduced the number of abdominal constrictions by 22.2, 44.4, 51.9, and 55.6%, respectively. A standard pain relieving (antinociceptive) drug, aspirin, reduced the number of writhings by 44.4 and 55.6%, respectively, when administered at doses of 200 and 400 mg per kg body weight. Conclusion. Antihyperglycemic and antinociceptive activities have not previously been reported for aerial parts of this variety of R. sativus. Since the plant is widely cultivated in Bangladesh, the aerial parts can be a good source for lowering blood sugar and for alleviating pain. W

Raphanus

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