Fathi H. Assaleh

Libyan Academy

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Prakash Katakam

Hindu College of Pharmacy

АM

Аleksandar Marinković

University of Belgrade

Babu Rao Chandu

Al Zawiya University

Shanta Kumari Adiki

Kanya Maha Vidyalaya

Bratislav Jovanović

University of Belgrade

Nagiat T. Hwisa

University of Illinois Urbana-Champaign

Gyöngyi Vastag

University of Novi Sad

Suzana Apostolov

University of Novi Sad

Borko Matijević

University of Novi Sad

Saša Drmanić

University of Belgrade

Cooperative Institutions

University of Belgrade

Al Zawiya University

Acharya Nagarjuna University

Guntur Medical College

Indian Institute of Technology Kharagpur

University of Novi Sad

Institute of Chemistry, Technology and Metallurgy

Institut za zdravstvenu zaštitu dece i omladine Vojvodine

Netaji Subhas University of Technology

Vinča Institute of Nuclear Sciences

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Multivariate assessment of azo dyes' biological activity parameters

Journal of Chromatography A (2018)

Gyöngyi Vastag Suzana Apostolov Borko Matijević Fathi H. Assaleh

Lipophilicity

Univariate

Chemometrics

Molecular descriptor

Source

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Citations (0)

QSRR approach in examining selected azo dyes

Journal of Liquid Chromatography &amp Related Technologies (2016)

Gyöngyi Vastag Suzana Apostolov Borko Matijević Fathi H. Assaleh

Azo dyes as the most numerous and widely applied class of synthetic dyes in various industries at the same time represent the great polluter of the aquatic systems and environment. Most of them are hydrophobic and resistant to degradation, but also they express diverse biological activity. The preliminary examinations of the bioactivity of the compounds include the estimation of their lipophilicity. The lipophilicity, as the key molecular descriptor for assuming an activity in a biological system for group of thiouracil azo dyes, was determined by the reversed-phase thin-layer chromatography (RPTLC18F254s) in different mixtures of water and (ethanol, i-propanol, dioxane, tetrahydrofurane) and mathematically using relevant software packages. The insight into the relationship between the chromatographic retention parameters, and m of azo dyes with the partition coefficient log P, was attained by applying the linear regression analysis, Cluster analysis, and principal component analysis. All the applied methods have resulted in good agreements of the studied lipophilicity parameters of azo dyes. Also, these methods provided significant informations about the influence of the organic modifier on one side as well as the impact of the polarity and the electronic effect of substituent of examined dyes on their lipophilicity.

Lipophilicity

10.1080/10826076.2016.1230748

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Citations (6)

Solvent and structural effects in tautomeric 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)-pyridones: experimental and quantum chemical study

Structural Chemistry (2014)

Ismail Ajaj Jasmina Markovski Jelena Marković Maja Jovanović Miloš Milčić

Quantum chemical

10.1007/s11224-014-0401-y

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Citations (8)

Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy (2018)

Dominik Brkić Aleksandra R. Božić Аleksandar Marinković Miloš Milčić Nevena Prlainović

Isatin

Quantum chemical

10.1016/j.saa.2018.01.080

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Citations (17)

Carbon-13 substituent chemical shifts in N-1-p-substituted phenyl-5-methyl-4-carboxy uracils

Journal of Molecular Structure (2006)

Fathi H. Assaleh Аleksandar Marinković Bratislav Jovanović János Csanádi

Chemical shift

Uracil

10.1016/j.molstruc.2006.09.002

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Citations (10)

Studying of physicochemical properties of newly synthesized uracil derivatives

Zastita materijala (2015)

Borko Matijević Gyöngyi Vastag Suzana Apostolov Jadranka Tot Fathi H. Assaleh

Uracil derivatives are potentially biologically active compounds, so the investigation of their physical and chemical properties is very important for their further application. In this work a series of newly synthesized derivatives of uracil was investigated by applying the spectrophotometric method. The absorption spectra were recorded in seventeen solvents with different properties. The effect of solvent was interpreted by Kamlet-Taft solvatochromic model. The dominance and the types of interactions that occur between the investigated derivatives and solvent were interpreted by applying the multiple linear correlation obtained values of absorption maxima and Hansen's solvent parameters. In addition to the effect of solvent, the influence of substituents in the molecule on absorption spectra was studied by applying Hammett equation.

Solvatochromism

Uracil

10.5937/zasmat1503279m

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Formulation and evaluation of sustained release venlafaxine tablets using hydrophilic-hydrophobic polymer combinations by melt granulation

Journal of Scientific and Innovative Research (2014)

Prakash Katakam Mr.B. Varun Kumar Reddy Nagiat T. Hwisa Fathi H. Assaleh Baishakhi Dey

The current research aims to formulate Venlafaxine Sustained Release (VHL-SR) tablets using hydrophilic-hydrophobic polymers combination blends by melt granulation technique which highlights the novelty. The polymers selected for the present study have matrix forming properties. Results of FTIR studies have shown that there were no interactions between the polymers used and the drug VHL. Various formulations of VHL- SR tablets (F1-F16) using different combinations of hydrophilic and hydrophobic polymers viz. Carbopol 71G, HPMC K15M, PEO, sodium CMC, Eudragit RS100 and precirol were formulated. Prior preformulation studies carried out on powder blend showed good flow properties. Routine quality evaluations of the VHL-SR tablets showed the diameter of the tablets of all formulations were found to be 9.0±0.0 mm and thickness ranged between 2.08±0.08 to 2.25±0.14 mm, hardness 4.08±0.20 - 5.50±0.31 kg/cm2 , percentage friability 0.24±0.03 - 0.45±0.01%, weight variation from 0-1.15%, drug content uniformity from 98.17±0.68 to 101.89±0.73%, all within Pharmacoepial limits. Results of in-vitro drug release study indicated that the formulation containing Carbopol 71G (50 mg), Xanthan gum (75 mg) and MCC (50 mg) extended the release of the VHL. Formulation F15 was the optimized one which gave satisfactory release (95.2%) for 16 hr and with a similarity factor (f2) 68.46, the release kinetics best explained by the Korsmeyer-peppas and Higuchi diffusion models. The “N” values between 0.5-1.0 in all the formulations exhibiting a non-Fickian release behavior controlled by a combination of diffusion and chain relaxation mechanism. The formulation showed appreciable stability under accelerated conditions after 2 m.

Friability

Granulation

10.31254/jsir.2014.3109

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Citations (2)

UV-SPECTROPHOTOMETRIC ESTIMATION OF ACYCLOVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Journal of Pharmaceutical and Scientific Innovation (2013)

Narayana Raju Padala Dey Baishakhi Fathi H. Assaleh Prakash Katakam Babu Rao Chandu

Analytical method development being a vital part of pre formulation - formulation research and development obviates the need to develop reliable, effective, e co friendly and cost effective methodologies for routine analysis of active pharmaceutical ingredients. UV spectroscopy is one of the earliest, yet of wide applications in drug analysis in different stages of formulations and quality control; despite the availabilities of sophisti cated chromatographic techniques and other hyphenated techniques. Current research attempts to develop simple, sensitiv e, accurate, precise and economical UV spectrophotometric methods for the routine analysis of acyclovir in bulk and pharmaceutical dosage forms using two separate alkaline medi a , 0.1N NaOH (method A) and 0.1N KOH (method B) and validate them as per ICH gui delines. In both the methods maximum absorbance was observed at 264 nm. Beer’s law was obeyed in the concentration of 2.5 - 40 µg / mL in method A and 2.5 - 30 µg / mL in method B with correlation co efficient of 0.999. The % recovery carried out by adding know n amount of standard drug to pre - analyzed tablet solutions was 98.75 ± 0.52 % to 99.78 ± 0.69 % (method A) and 98.55 ± 0.31 % to 99.78 ± 0.22 % (method B). Intra and interday precision expressed in % RSD were 0.38 ± 0.01 and 0.27 ± 0.02 - 0.44 ± 0.01 respe ctively and the percent purity was 99.85 ± 0.05 %. The methods were validated statistically as per ICH guidelines and the results obtained were within the acceptance criteria for the param eters relating to linearity, accuracy, precision.

10.7897/2277-4572.02451

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Citations (7)

Synthesis and characterisation of starch tartrate and its application as novel disintegrant in telmisartan tablets

Starch - Stärke (2013)

Fathi H. Assaleh Prakash Katakam Ramesh Botcha Babu Rao Chandu Shanta Kumari Adiki

Abstract The aim of the present study was to synthesize potato starch (PS) derivatives of tartaric acid (TA) under semi‐dry conditions and to evaluate the physicochemical properties as per official compendia requirements. Starch tartrate (ST) was synthesized by reacting PS (St–OH) and TA in semi‐dry condition using sodium hypophosphite (SHP) as a catalyst. Further we have applied its use as disintegrant in directly compressed telmisartan tablets. The microscopic, spectroscopic (FTIR), thermal (DSC) and crystallographic (XRD) studies confirmed the formation of ST. No gelling was observed at 100°C but it was converted to a clear solution with a swelling index of 1.666 times. ST was found to have suitable compression properties required for directly compressible tablets. The tablets formulated employing ST (5–15% w/w) as disintegrant gave rapid disintegration and dissolution rates compared to those prepared using commercial superdisintegrants (sodium starch glycolate and crosscarmellose sodium). The optimized formulation showed disintegration time of 31 ± 3 s which is found superior to that of others. It is concluded that the synthesized ST could be employed as a promising disintegrant in dispersible tablet formulations.

Tartaric acid

Telmisartan

Friability

Tartrate

10.1002/star.201300136

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Citations (1)

Experimental design optimization of RP-HPLC method for simultaneous estimation of metsulfuron-methyl, chlorantraniliprole and chlorimuron-ethyl residues in stems of Oryza sativa

Future Journal of Pharmaceutical Sciences (2021)

Shanta Kumari Adiki Prakash Katakam Fathi H. Assaleh

Abstract Background The study aims to develop a chemometrics optimized D-optimal mixture design approach assisted RP- HPLC method for the determination of pesticide residues of metsulfuron-methyl, chlorantraniliprole, and chlorimuron-ethyl in the stems of Oryza sativa . Chromatographic separation was achieved on a C18 column using a mobile phase consisting of a pH 3.5 phosphate buffer and acetonitrile in the ratio 85:15. Results The optimized HPLC method gave a sharp resolution of metsulfuron-methyl, chlorantraniliprole and chlorimuron-ethyl at a retention time of 2.599 min, 3.805 min and 4.661 min receptively. Linearity was observed in the range 100‒500 µg/mL for metsulfuron-methyl ( r 2 = 0.999), 4‒20 µg/mL for chlorantraniliprole ( r 2 = 0.999) and 100‒500 µg/mL for chlorimuron-ethyl ( r 2 = 0.999). The developed method was validated as per ICH guidelines. Conclusion The proposed chemometrics optimized RP-HPLC method was found to be successful in the resolution of pesticide residues in the stems of O. sativa . The developed method can be applied to routine quantification of metsulfuron-methyl, chlorantraniliprole and chlorimuron-ethyl.

Chemometrics

Phosphate buffered saline

10.1186/s43094-021-00372-7

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Citations (2)