Nicolas Dumont

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Co-Authors

Léa Bordes

Interaction Hôtes Agents Pathogènes

Anne Lespine

CNR de la Résistance aux Antibiotiques

Philippe Jacquiet

Interaction Hôtes Agents Pathogènes

Christelle Grisez

Interaction Hôtes Agents Pathogènes

Clément Delmas

Centre Hospitalier Universitaire de Toulouse

T. Cazajous

Aurélie Dailledouze

Interaction Hôtes Agents Pathogènes

Françoise Prévot

Interaction Hôtes Agents Pathogènes

Corinne Vial-Novella

Institut de l’Elevage

M. Abbadie

Université de Toulouse

Cooperative Institutions

Université de Toulouse

École Nationale Vétérinaire de Toulouse

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Interaction Hôtes Agents Pathogènes

Département Santé Animale

Institut National Polytechnique de Toulouse

Université Toulouse III - Paul Sabatier

CNR de la Résistance aux Antibiotiques

Innovations thérapeutiques et résistances

Institut National de la Recherche Agronomique

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First report of multiple resistance to eprinomectin and benzimidazole in Haemonchus contortus on a dairy goat farm in France

Parasitology International (2020)

Léa Bordes Nicolas Dumont Anne Lespine Elise Souil Jean‐François Sutra

Moxidectin

Benzimidazole

Doramectin

10.1016/j.parint.2020.102063

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Citations (35)

First report of eprinomectin-resistant isolates ofHaemonchus contortusin 5 dairy sheep farms from thePyrénées Atlantiques départementin France

Parasitology (2023)

Sophie Jouffroy Léa Bordes Christelle Grisez J. F. Sutra T. Cazajous

Abstract Infection of sheep by gastrointestinal nematodes (GIN) in pastoral systems such as those found in the South Western area of France, the Pyrénées Atlantiques , is one of the main reasons for economic loss and degradation of their welfare. In the present study, the efficacy of eprinomectin (EPN) was monitored on farms from this area following suspicion of lack of anthelmintic efficacy. Suspicions were raised by veterinarians, based on clinical signs ranging from milk and body condition loss, to anaemia, and mortality. Resistance was evaluated according to the World Association for the Advancement for Veterinary Parasitology (WAAVP) guidelines using fecal egg count reduction tests reinforced by individual analysis of drug concentration in the serum of all treated ewes by high-performance liquid chromatography (HPLC). EPN was administered by subcutaneous (SC) and topical (T) route according to manufacturer's requirements, as well as by the oral route (O) with the topical solution according to off-labelled practices in the field. For the first time in France, the presence of resistant isolates of Haemonchus contortus to EPN was observed in 5 dairy sheep farms. The HPLC dosages showed exposure of worms to concentrations compatible with anthelmintic activity for animals treated by the SC and O routes. By contrast, they showed under exposure to the drug of most individuals treated by the T route. EPN is the only null milk withdrawal anthelmintic molecule currently available. The presence of resistant isolates of the pathogenic H. contortus to EPN in this important dairy region requires an urgent change in grazing, and sometimes production, systems.

Dose

Parasitology

Eggs per gram

Veterinary parasitology

10.1017/s0031182023000069

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Citations (6)