Abstract The controlled release of drug molecules to a specific brain tumour's tissue has been recognized as one of the most demanding researches for treatment of brain cancer, because it helps to avoid the side effects from systemic drug delivery techniques. In the present work, described an electrochemically controlled drug delivery performed with a reduced graphene oxide (rGO)‐drug composite. The rGO was loaded with a temozolomide ( TMZ ) molecule ( rGO ‐ TMZ ) exhibits electrochemical oxidation and reduction peak in 0.1 M phosphate buffer solution ( pH 7.4). In response to be electrochemical potential, the rGO ‐ TMZ composite releases TMZ drug, and TMZ drug dosage that can be adjusted by altering the electrochemical potential with time. Upon application of an electrochemical potential pulse (0.8 V) for 20 min duration, up to 83% of TMZ was released into citrate buffer solution at pH 5.0. In vitro, cell culture experiments demonstrate that the released TMZ drug retains its bioactivity. The electrochemically controlled rGO‐ TMZ composite drug delivery platform makes it an exciting candidate for on‐demand drug delivery for effective treatment of brain cancer.

Temozolomide

10.1002/mds3.10014

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Molecular Docking Analysis of Chlorogenic Acid Against Matrix Metalloproteinases (MMPs)

Biointerface Research in Applied Chemistry (2020)

Dhivyadharshini Govindharaj Saraswathy Nachimuthu Dymphan Fidelics Gonsalves Ram Kothandan Bhaarathi Dhurai

Wound healing is one of the most critical and complex processes in the human system, which involves many enzymes. Overexpression of Matrix metalloproteinases (MMPs) at the wound site delay the wound healing process. These overexpressed MMPs can be down-regulated or inhibited using small bioactive molecules derived from natural sources. Chlorogenic acid is a polyphenol derivative found in coffee and a well-known antioxidant. The main objective of the study is to unveil the molecular mechanism by which chlorogenic acid binds to the MMPs through molecular docking studies. The result of docking studies showed that chlorogenic acid showed an excellent binding affinity towards all four selected MMPs. The free binding energy of MMPs 2, 3, 8, and 12 were about -9.32, -8.17, -8.85, and -7.431kcal/mol, respectively. Thus, chlorogenic acid can be used to regulate the activity of metalloproteinases and help to promote wound healing activity.

Chlorogenic Acid

Docking (animal)

10.33263/briac106.68656873

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NiO Nanoparticles Based Carbon Paste as a Sensor for Detection of Dopamine

International Journal of Electrochemical Science (2018)

Sathish Reddy B.E. Kumara Swamy Seeram Ramakrishana Liumin He H. Jayadevappa

In this paper, NiO nanoparticles were synthesized using cetyl trimethyl ammonium bromide (CTAB) and sodium dodecyl sulfate (SDS).The prepared NiO nanoparticles were applied for the preparation of modified carbon-paste electrodes (MCPE) for the electrochemical investigations of potassium ferrocynide K 4 [Fe(CN) 6 ] and dopamine (DA).The MCPE prepared from CTAB-NiO nanoparticles demonstrated an enhanced sensing response for K 4 [Fe(CN) 6 ] and DA as compared with those of the MCPE fabricated from SDS-NiO nanoparticles.The MCPE prepared from SDS/polyglycine/CTAB-NiO nanoparticles demonstrated a further enhanced peak current response and effectively analyzed simultaneously DA, Ascorbic acid (AA), Uric acid (UA) and Bisphenol-A (BPA).

Non-blocking I/O

Carbon Nanoparticles

10.20964/2018.06.06

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High performance anti‐smog window screens via electrospun nanofibers

Journal of Applied Polymer Science (2019)

Lin Du Youchen Zhang Xiangnan Li Jun Wang MingJun Chen

ABSTRACT Scientific studies clearly link air pollution with adverse effects on human health, which includes reduction of cognitive abilities. Hence quality indoor air is essential in rapidly urbanizing societies. The aim of this research work is to develop anti‐smog, air permeable, water‐proof, and transparent window screens suitable for natural ventilation. For this purpose, we bonded polyethylene terephthalate (PET) nanofibers on PET grids by electrospinning method with relative near spinning distance. During the process, the incomplete solvent evaporation of the collected jet could enhance the bonding of the PET nanofibers to the PET grids. The experimental results showed that the PET nanofibers had a thick deposition at the yarn edge of the PET grids, which also increased the bonding area between the PET nanofibers and the grids. At the same time, PET nanofibers had a thin deposition between the gaps of the PET grids, which not only increased the number of micron‐nano‐sized holes but also increased the light transmittance of the window screen. After filtration test for 5 h, the PM2.5 filtration efficiency of this anti‐smog window screen was high as to 87% and the PET nanofiber window screen still maintained high light transmittance and superhydrophobicity. This research work is a promising way to prepare anti‐smog window screens. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 137 , 48657.

Electrospinning

Filtration (mathematics)

10.1002/app.48657

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Citations (16)

Allotropic carbon (graphene oxide and reduced graphene oxide) based biomaterials for neural regeneration

Current Opinion in Biomedical Engineering (2018)

Sathish Reddy Xiaoting Xu Ting Guo Rong Zhu Liumin He

10.1016/j.cobme.2018.05.001

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Citations (39)

Graphene nanomaterials for regulating stem cell fate in neurogenesis and their biocompatibility

Current Opinion in Biomedical Engineering (2019)

Sathish Reddy Liumin He Seeram Ramakrishana Hongrong Luo

Regenerative Medicine

10.1016/j.cobme.2019.04.002

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Citations (15)

CNTs-COOH Paste Electrode for Detection of Temozolomide

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Sathish Reddy Gade Archana Rong Zhao Qiao Xiao Chem Shenfeng

The MWCNTs-COOH Paste Electrode (MCPE) was successfully used to study the electrochemical behavior of temozolomide in 0.2 M H2SO4 solution, phosphate buffer solution (0.1M PBS, pH 7.4) and 0.1M NaOH solution by Cyclic Voltammetry (CV) technique. The results exhibit that MCPE can remarkably enhance sensing and electrocatalytic activity towards the oxidation and reduction of temozolomide in acidic, neutral, and basic solutions. The effect of the scan rate exhibits the adsorption controlling process. The effect of pH range from 2 to 6 was investigated by cyclic voltammetry technique, from cyclic voltammetry study exhibits the peak current was pH-dependent with a slope of 68 mV/pH. The detection limit (LOD)) at MCPE were found to be 0.056 mM,0.069 mM and 0.065 mM in 0.1M H2SO4, 0.1M PBS (pH 7.4) and 0.1M NaOH solutions respectively by Cyclic Voltammetric (CV) technique. Similarly, from Linear Scan Voltammetric (LSV) technique, the detection limits (LOD) were found to be 0.050 mM, 0.021mM and 0.036 mM in acidic, neutral, and basic solution respectively. The proposed method was successfully applied for the determination of temozolomide in the clinical sample.

Horizontal scan rate

Phosphate buffered saline

Buffer solution

Temozolomide

10.30492/ijcce.2020.32996

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Nanodrop Spectrophotometric Method for Estimation of Ranitidine Hydrochloride in Bulk and Tablet Dosage Form

Asian Journal of Research in Chemistry (2010)

Singh Kumar Rakesh Seeram Ramakrishana Patel Singh Pankaj Pragya Gupta

A novel, simple, sensitive and rapid nanodrop spectrophotometric method was developed for the estimation of Ranitidine hydrochloride in bulk and its pharmaceutical tablet dosage form. Ranitidine hydrochloride exhibiting maximum absorbance at 316 nm in distilled water and obeyed linearity in the concentration range of 5–100 ppm. The proposed method has been applied successfully for the analysis of Ranitidine hydrochloride either in bulk or pharmaceutical tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride in pharmaceutical tablet dosage form.

Absorbance

Distilled water

Ranitidine Hydrochloride

Pharmaceutical formulation

Source

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