Vasim Masakputra

Era's Lucknow Medical College and Hospital

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Zeba Siddiqi

Era's Lucknow Medical College and Hospital

Saboor Mateen

Era's Lucknow Medical College and Hospital

Jalees Fatima

Era's Lucknow Medical College and Hospital

Aquib Ashfaq

Era's Lucknow Medical College and Hospital

Aditya Barbhuyan

Era's Lucknow Medical College and Hospital

Sana Sajid

Era's Lucknow Medical College and Hospital

Vaibhav Shukla

Tech Mahindra (India)

Ajay Mishra

Sanjay Gandhi Post Graduate Institute of Medical Sciences

Farzana Mahdi

Era's Lucknow Medical College and Hospital

Sachin Khanduri

Era's Lucknow Medical College and Hospital

Cooperative Institutions

Era's Lucknow Medical College and Hospital

Institute of Medical Sciences

All India Institute of Medical Sciences

Krishna Institute of Medical Sciences

Career Institute Of Medical & Dental Sciences and Hospital

Marymount University

Baba Raghav Das Medical College

Texila American University

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Jinnah Postgraduate Medical Center

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Prevalence of Comorbidities in Survivors and Non-Survivors of Severe COVID-19 at a Dedicated COVID Care Centre.

PubMed (2022)

Zeba Siddiqi Jalees Fatima Divyansh Bhatt Vaibhav Shukla Mohd Mustahsin

Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. Diseases such as diabetes, hypertension, cardiovascular and pulmonary diseases are common comorbidities in COVID-19 patients and have been correlated with increased disease severity. Comorbidities lead the COVID-19 patient into a vicious infectious circle and are substantially associated with significant morbidity and mortality. This study was aimed to estimate prevalence of comorbidities in severe category of COVID survivors and non survivors. More than 90% patients with multiple comorbidities admitted to ICU did not survive compared to those with one or two comorbidities. Diabetes followed by hypertension was the most common comorbidity in these patients. Thus comorbid individuals must adopt vigilant preventive measures including vaccination and they require intensive management for better outcome.

2019-20 coronavirus outbreak

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A Rare Case of Longitudinally Extensive Transverse Myelitis in Scrub Typhus

Annals of Indian Academy of Neurology (2023)

Ajay Mishra Saboor Mateen Varun Malhotra Jalees Fatima Vasim Masakputra

Mishra, Ajay; Mateen, Saboor; Malhotra, Varun; Fatima, Jalees; Masakputra, Vasim Author Information

10.4103/aian.aian_816_23

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Incidence, Pattern, Causes, and Outcome of Acute Chest Pain Among Patients Presenting in the Emergency Department of a Tertiary Care Hospital in North India

Cureus (2024)

Saboor Mateen Vasim Masakputra Zeba Siddiqi Jalees Fatima

Background: Acute chest pain is a common presentation in emergency departments worldwide. Differentiating between cardiac and non-cardiac chest pain is crucial for patient management and resource allocation. Methods: This study analyzed 714 patients presenting with acute chest pain in a tertiary care hospital in North India. We investigated demographic characteristics, chief complaints, risk factors, ECG findings, and final diagnoses to identify patterns associated with cardiac (CCP) and non-cardiac chest pain (NCCP). Results: CCP was diagnosed in 53.7% (n=383) and NCCP in 46.3% (n=331). Significant predictors of CCP included age (OR=1.05, p<0.001), smoking (OR=2.22, p<0.001), diabetes (OR=1.57, p=0.003), hypertension (OR=1.82, p<0.001), and family history of ischemic heart disease (IHD) (OR=1.42, p=0.01). Central chest pain was more common in CCP (60% vs. 40%, p<0.001), as were abnormal ECG findings such as ST-segment depression (35% vs. 10%, p<0.001) and elevation (29% vs. 6%, p<0.001). Normal ECG was more prevalent in NCCP (60%, p<0.001). Conclusion: Traditional cardiovascular risk factors remain strongly associated with CCP. Smoking has a particularly high odds ratio, suggesting the need for targeted interventions. ECG findings significantly aid in differentiating CCP from NCCP. This study underscores the importance of a comprehensive approach in evaluating acute chest pain to ensure accurate diagnosis and effective treatment.

10.7759/cureus.56115

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CORONARY ARTERY CALCIFICATION AS A MARKER OF SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS OF NON ALCOHOLIC FATTY LIVER DISEASE

Journal of Hypertension (2023)

Zeba Siddiqi Aquib Ashfaq Irshad Wani Sachin Khanduri Sana Sajid

Objective: Non Alcoholic Fatty Liver Disease (NAFLD) has been proposed to have a strong association with coronary artery disease(CAD) and subclinical atherosclerosis . Coronary artery calcification (CAC) is the well-established non-invasive surrogate index of atherosclerotic burden in arterial beds independent of conventional risk factors. Present study was an attempt to assess CAD risk in NAFLD patients by estimating coronary calcification. Design and method: cross sectional. Sonographically confirmed NAFLD patients between 30-60 years of either sex were included after obtaining informed consent and study approval by institutional ethics committee. Those with alcohol intake,acute and chronic infectious diseases, patients on parenteral nutrition, hepatotoxic drug intake, pregnant and lactating women and known CAD were excluded. History, Examination and investigations were recorded. CAC estimation was performed using 384 slice Dual source machine and CAC score was calculated by Agatston method. Statistical analysis by SPSS. Results: Out of 152 NAFLD patients, 79 (52.0%) were Grade I, 37 (24.3%) were Grade II and 36 (23.7%) Grade III. Mean age was 49 years with 86 males and 66 females. Considering comorbidities; 47 were diabetic,62 hypertensive, 36 hypothyroid and 6 dyslipidemic. CACS of patients ranged from zero to 620.80. Observed CACS and CAD Risk in NAFLD patients Significantly increased CACS were observed in Grade III NAFLD cases (208.08±193.92) followed by Grade II (53.90±82.67) and minimum in Grade I (9.84±52.93). Conclusions: Accelerated atherosclerosis in NAFLD maybe due to high oxidative stress,inflammatory markers like TNF Alpha, interleukin-6, oxidized LDL, insulin resistance, and macrophage activation. Present study was conducted to estimate coronary artery calcification in NAFLD by determining coronary artery calcium scores. Higher grades of NAFLD patients had moderate to high risk of CAD as evidenced by high CACS. This study shows that asymptomatic patients of NAFLD may have high atherosclerotic burden thus need to commence preventive measures before occurrence of an adverse CV event.

Subclinical infection

Surrogate endpoint

Agatston score

10.1097/01.hjh.0000940220.08065.98

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