Objective To investigate the clinical features of venous catheter associated Flavimonas oryzihabitans sepsis.Methods Bacterial cultures from peripheral blood and intravenous catheter blood samples of patients with catheter-related sepsis were immediately performed.The contents and apex of catheters were also sent for bacterial culture after the catheters were removed.Results There were no inflamed,painful and secretive symptoms at catheter porch in all 15 patients.The most important clinical manifestation was sudden-onset of irregular fever and chilling.The temperature was ranged from 37.8℃ to 40℃.Eleven cases(73.3%) had a body temperature of over 38.5℃.Two patients(13.3%) had cough and mucous purulent sputum.Flavimonas oryzihabitans was found in peripheral blood and intravenous catheter blood samples of these 15 patients.Seven cases of catheter apex showed positive bacterial culture.All 15 strains of Flavimonas oryzihabitans were sensitive to Piperacilly,Ticarcillin/Clavulanate,Amikacin,Ceftazidime,Cefoperazone /Sulbactam,Imipenem /Cilastatin and Ofloxacin,but not to Cefoxitin,Cefuroxime sodium,Cefazolin,Aztreonam.Three isolated strains were resistant to Amoxicillin and 2 strains were resistant to Cefalotin and Ceftiaxone.Twelve cases were cured and 3 cases of dead.Conclusion Venous catheter associated Flavimonas oryzihabitan sepsis was mostly developed in patients with other underlying diseases and immunodeficiency.Isolated bacterial strains were generally highly resistant to the 1st and 2nd generations Cephalosporins and Aztreonam.
To evaluate the effect of different dose of anticoagulants in haemodialysis patients with acute coronary syndrome (not including ST-elevate myocardial infarction).
Methods
28 patients with ACS (not including ST-elevate myocardial infarction) were enrolled between March 2008 and March 2012 who started haemodialysis for 5–10 years in regular pattern. The patients were randomly divided into two groups: the routine group (n=12) and strengthen group (n=16). All patients were given routine therapy including regular haeparinised haemodialysis (three times a week), rest, oxygen inhaling, antiplatelet, reducing blood lipid levels, controlling the blood pressure. The patients in the routine group were given the factor X a inhibitor fondaparinux 2.5 mg every day except the haemodialysis days. The patients in the strengthen group were given fondaparinux 2.5 mg every day including the haemodialysis days. The course of treatment was 7 days. Observe the symptom, electrocardiogram, cardiac troponin T, coagulation function (PT, APTT, INR) for 14 days.
Results
One patient in routine group was died of heart failure, another patients in strengthen group exited because of gastrointestinal bleeding. The basic characteristics of the two groups were identical (p>0.05). Patients9 symptom relieved in (3.1±2.8) days in strengthen group and (5.0±3.6) days in routine group (p<0.05). Patients9 electrocardiogram returned to the origin in (4.5±2.1) days in strengthen group and (5.8±4.3) days in routine group (p<0.05). The cardiac troponin T of patients in strengthen group reduced to stable level in (4.7±5.2) days and (5.8±2.9) days in routine group (p<0.05). In the 3rd day and 5th day and 7th day and 9th day, the PT, APTT, INR in strengthen group were significantly longer than those in routine group (p<0.05).
Conclusions
Strengthen anticoagulant therapy in haemodialysis patients with acute coronary syndrome (not including ST-elevate myocardial infarction) is more effective than routine therapy, but we must be care of the risk of haemorrhage.
Objective To analyze the clinical effect and safety of endoscopy combined with selective cyclooxygenase 2 inhibitors for patients with esophageal atypical hyperplasia.Methods Totally 63 patients with esophageal atypical hyperplasia were studied and divided into control group(n=30) and experiment group(n=33).Endoscopy was applied in control group while selective cyclooxygenase 2 inhibitors therapy combined with endoscopy was used in experimental group.The clinical effect,expressions of vascular endothelial growth factor(VEGF) and safety were compared between the two groups after the therapy finished.Results After 12 months,there were marked differences between the two groups in the clinical effect and the expressions of VEGF(P0.05).Conclusion The therapy of endoscopy combined with selective cyclooxygenase 2 inhibitors for patients with esophageal atypical hyperplasia is effective and safe.
Objective: To study the roles of mast cells in the pathogenesis of the irritable bowel syndrome (IBS) by determining the distribution and number of mast cells in the ileocecal and rectosigmoid junctions. Methods:Formalin-fixed and paraffin-embedded tissue samples from patients with IBS were stained immunohistochemically. The positively stained mast cells were detected by using a monoclonal antibody against tryptase. Results:The number of mast cells in the ileocecal junction was significantly higher in patients with IBS than that in controls (P0.05), especially in patients with diarrhea-predominant IBS (P0.01). The number of mast cells in the rectosigmoid junction in patients with IBS did not increase markedly, but the degranulation of mast cells was remarkable. The number of mast cells in the ileocecal and rectosigmoid junctions increased with no statistical significance in patients with active and nonspecific colonitis. Conclusion:An increase in the number of mast cells in the ileocecal junction may be involved in the pathogenesis of IBS.
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