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Anastasiya Sidarenka

National Academy of Sciences of Belarus

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Galina Novik

Institute of Microbiology

Leonid Valentovich

National Academy of Sciences of Belarus

A. E. Akhremchuk

National Academy of Sciences of Belarus

В. В. Савич

Powder Metallurgy Institute

Viktoryia Kulikouskaya

Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

V. V. Nikalaichuk

Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

Aliaksandra Herasimovich

National Academy of Sciences of Belarus

Kseniya Hileuskaya

Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

Katsiaryna Y. Skapavets

Belarusian Research Center For Pediatric Oncology and Hematology

Aliaksandr Kraskouski

Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

Cooperative Institutions

National Academy of Sciences of Belarus

Belarusian State University

Institute of Microbiology

Russian Academy of Sciences

Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus

Institute of Bioorganic Chemistry

N.D. Zelinsky Institute of Organic Chemistry

University of Aveiro

Academy of Sciences Republic of Uzbekistan

Lund University

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Antibiotic resistance in lactococci and enterococci: phenotypic and molecular-genetic aspects

The EuroBiotech Journal (2017)

Danuta Tofilevna Plotnikava Anastasiya Sidarenka Galina Novik

Abstract Extensive use of antibiotics in medicine, veterinary practice and animal husbandry has promoted the development and dissemination of bacterial drug resistance. The number of resistant pathogens causing common infectious diseases increases rapidly and creates worldwide public health problem. Commensal bacteria, including lactic acid bacteria of genera Enterococcus and Lactococcus colonizing gastrointestinal and urogenital tracts of humans and animals may act as vehicles of antibiotic resistance genes similar to those found in pathogens. Lactococci and enterococci are widely used in manufacturing of fermented products and as probiotics, therefore monitoring and control of transmissible antibiotic resistance determinants in industrial strains of these microorganisms is necessary to approve their Qualified Presumption of Safety status. Understanding the nature and molecular mechanisms of antibiotic resistance in enterococci and lactococci is essential, as intrinsic resistant bacteria pose no threat to environment and human health in contrast to bacteria with resistance acquired through horizontal transfer of resistance genes. The review summarizes current knowledge concerning intrinsic and acquired antibiotic resistance in Lactococcus and Enterococcus genera, and discusses role of enterococci and lactococci in distribution of this feature.

Enterococcus faecium

Lactococcus

10.24190/issn2564-615x/2017/01.03

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Citations (1)

Design of Highly Porous Materials Based on Chitosan/Pectin Interpolyelectrolyte Complex for Wound Healing Application

Advances in Polymer Technology (2024)

Aliaksandr Kraskouski Maksim Mashkin Viktoryia Kulikouskaya В. В. Савич Anastasiya Sidarenka

Interpolyelectrolyte complexes (IPECs) of polysaccharides are multifunctional polymer materials that improve the mechanical and physicochemical properties of individual polysaccharides. In this study, highly porous (>90%) materials based on IPECs of versatile natural polysaccharides, chitosan (30 and 1,200 kDa) and pectin, are obtained by freeze-drying technique. To enhance the interaction between chitosan and pectin macromolecules, the latter are chemically functionalized with dialdehyde groups. The chitosan-/aldehyde-functionalized pectin (Chit/AF-Pect) polyelectrolyte complex sponges obtained are characterized using SEM, FTIR spectroscopy, and TGA. The swelling capacity study reveals a higher swelling ratio of IPEC sponges with an increase in both the molecular weight and content of chitosan: for Chit30/AF-Pect, the swelling ratio rises from 327% to 480%, while for Chit1200/AF-Pect, from 681% to 1,066%. Additionally, the in vitro degradation test demonstrates higher stability of Chit1200/AF-Pect sponges in comparison with those of Chit30/AF-Pect: after 4 days of incubation, the weight losses are found to be 9%–16% and 18%–41%, respectively. The cytotoxicity study shows that Chit30/AF-Pect sponges are noncytotoxic, with cell viability values >70%. Furthermore, the Chit30/AF-Pect sponges, obtained at chitosan:pectin weight ratio of 5:1, exhibit bactericidal activity against Escherichia coli BIM B-984 G, Pseudomonas aeruginosa BIM B-807 G, Staphylococcus aureus BIM B-1841, and slightly inhibit the growth of Enterococcus faecalis BIM B-1530 G. These findings indicate that the obtained Chit30/AF-Pect sponges can be used to create wound dressings for wound healing applications.

Pectin

Wound dressing

10.1155/2024/8747902

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Alginate coated biogenic silver nanoparticles for the treatment of Pseudomonas infections in rainbow trout

International Journal of Biological Macromolecules (2023)

Viktoryia Kulikouskaya V. V. Nikalaichuk Kseniya Hileuskaya Alena Ladutska Karine Grigoryan

Zeta potential

Pseudomonas fluorescens

Silver nanoparticle

Pseudomonas putida

Bacterial growth

10.1016/j.ijbiomac.2023.126302

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Starter cultures of lactic acid bacteria for special diet products

The EuroBiotech Journal (2017)

Hanna Aljaksandrauna Bareika Anastasiya Sidarenka Galina Novik

Abstract From fresh and fermented vegetables (cucumber, sauercraut, eggplant), cereals (wheat, rice), legumes (soy) 37 cultures of lactic acid bacteria were isolated. Based on biochemical characteristics, MALDI-TOF MS protein profiling and 16S rRNA gene sequencing they were identified as representatives of Lactobacillus, Lactococcus, Leuconostoc, Pediococcus and Enterococcus genera. Six members of Lactobacillus genera and two members of Leuconostoc genera actively producing EPS were selected for further investigation as components of starters for production of special dietetic foodstuffs.

Pediococcus

Lactococcus

Starter

10.24190/issn2564-615x/2017/01.15

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Isolation and characterization of fast‐growing green snow bacteria from coastal East Antarctica

MicrobiologyOpen (2020)

Margarita Smirnova Uladzislau Miamin Achim Köhler Leonid Valentovich A. E. Akhremchuk

Abstract Snow microorganisms play a significant role in climate change and affecting the snow melting rate in the Arctic and Antarctic regions. While research on algae inhabiting green and red snow has been performed extensively, bacteria dwelling in this biotope have been studied to a much lesser extent. In this study, we performed 16S rRNA gene amplicon sequencing of two green snow samples collected from the coastal area of the eastern part of Antarctica and conducted genotypic and phenotypic profiling of 45 fast‐growing bacteria isolated from these samples. 16S rRNA gene amplicon sequencing of two green snow samples showed that bacteria inhabiting these samples are mostly represented by families Burkholderiaceae (46.31%), Flavobacteriaceae (22.98%), and Pseudomonadaceae (17.66%). Identification of 45 fast‐growing bacteria isolated from green snow was performed using 16S rRNA gene sequencing. We demonstrated that they belong to the phyla Actinobacteria and Proteobacteria , and are represented by the genera Arthrobacter , Cryobacterium , Leifsonia , Salinibacterium , Paeniglutamicibacter , Rhodococcu s, Polaromonas , Pseudomonas , and Psychrobacter . Nearly all bacterial isolates exhibited various growth temperatures from 4°C to 25°C, and some isolates were characterized by a high level of enzymatic activity. Phenotyping using Fourier transform infrared (FTIR) spectroscopy revealed a possible accumulation of intracellular polymer polyhydroxyalkanoates (PHA) or lipids in some isolates. The bacteria showed different lipids/PHA and protein profiles. It was shown that lipid/PHA and protein spectral regions are the most discriminative for differentiating the isolates.

Arthrobacter

Marine bacteriophage

Pseudoalteromonas

10.1002/mbo3.1152

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Dependence of Antimicrobial Effects of Guanidine-containing Pectin Derivatives from Some Structural Characteristics

Drug development & registration (2022)

Oliy R. Akhmedov Shavkat Shomurotov А. С. Тураев Anastasiya Sidarenka

Introduction. Up to the present time, there are practically no studies on the relationship between the structural characteristics and biological activity of antimicrobial polymers synthesized by the chemical addition of guanidine groups to polysaccharide macromolecules. Therefore, there is a need to carry out the chemical modification of guanidine with natural polymers, in particular polyaldehyde pectin, and to conduct comparative studies of the antimicrobial activity of the obtained samples with different physicochemical characteristics. Aim. To conduct the synthesis of guanidine-containing pectin derivatives. In addition, to determine the influence of structural variations in the obtained samples on exhibiting antimicrobial properties. Materials and methods. The synthesis of guanidine-containing pectin derivatives consisted of the following stages: periodate oxidation of the polysaccharide, modification of guanidine using polyaldehyde pectin, and chemical reduction of azomethine bonds. The amount of guanidine in the obtained samples was calculated by acidimetric titration, the nitrogen content (N, %) was determined using a Eura EA (Italy) elemental analyzer. The рКα values of the synthesized compounds were found by the back titration method. Absorption spectra were analyzed on a "UV 1280" spectrophotometer (Shimadzu, Japan) in the range λ = 180–400 nm. IR spectra were recorded on a Vector-22 spectrometer in the wavelength range of 400–4000 cm -1 in KBr tablets (3 mg sample / 300 mg KBr). The molecular weight characteristics of the synthesized derivatives were determined by high-performance gel permeation chromatography on an Agilent 1260 Infiniti liquid chromatograph. The acute toxicity of guanidine-containing pectin derivatives was calculated by the Prozorovsky method. Comparative assessment of antimicrobial activity was conducted by agar diffusion method. Results and discussion. By varying the oxidation level of polyaldehyde pectin, synthesized compounds differ in the degree of substitution, guanidine content, molecular weight, and pKα value. It was found that the levels of the antibacterial and antifungal activity of the studied samples depend on the degree of substitution and the nature of the counterion. The antimicrobial effect increases with an increase in the quantitative content of guanidine groups in the macromolecular chain of pectin. Moreover, it was found that the change of low molecular weight Cl – , NO 3 – , F – , I – counterions by carboxylate anions leads to a sharp decrease in antimicrobial properties. Upon oral injection of the synthesized compounds to mice, it was found that all samples belong to the category of practically non-toxic substances (V-class). Conclusion. Comparative analysis of guanidine-containing pectin derivatives with different characteristics showed that the severity of the antimicrobial action of the synthesized compounds against bacteria and fungi of the genus Candida depends on the quantitative content of cationic groups and the nature of the counterion.

Guanidine

Pectin

Gel permeation chromatography

Chemical structure

10.33380/2305-2066-2022-11-2-38-45

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Citations (3)

Structure of the cell wall polysaccharides of probiotic bifidobacteria Bifidobacteriumbifidum BIM B-465

Carbohydrate Research (2009)

Evelina L. Zdorovenko Вадим В. Качала Anastasiya Sidarenka Anastasia V. Izhik Elena P. Kisileva

Heteronuclear molecule

Homonuclear molecule

Monosaccharide

10.1016/j.carres.2009.08.039

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Citations (20)

Isolation, characterization, and whole-genome analysis of the novel temperate bacteriophage Ph-p5 infecting Glutamicibacter halophytocola

Archives of Virology (2025)

В. В. Савич A. E. Akhremchuk Aliaksandra Herasimovich Sviatlana I. Leanovich Leonid Valentovich

Isolation

Virus isolation

Temperateness

Medical microbiology

10.1007/s00705-025-06225-5

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Study of the Interaction Between Biogenic Alginate-Ag Nanoparticles and Enrofloxacin: Combinatory Antibacterial Effect and Nanocomposite Formation

BioNanoScience (2023)

V. V. Nikalaichuk Katsiaryna V. Hiatsevich Viktoryia Kulikouskaya Alena Ladutska Anastasiya Sidarenka

Silver nanoparticle

Thermogravimetric analysis

10.1007/s12668-023-01257-0

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Citations (2)

BIFIDOBACTERIA: THE PROBLEMS OF IDENTIFICATION AND NEW TECHNOLOGIES OF PROBIOTICS FOR MEDICINE

Health and Ecology Issues (2006)

Galina Novik Anastasiya Sidarenka

The review is devoted to the problems of identification and classification of probiotic strains of bifidobacteria that are widely used in manufacturing of medications and functional food products. It also discusses prospects of development of new probiotic products on the base of well-known commercial strains and possibilities of their wider use in different areas.

Identification

10.51523/2708-6011.2006-3-4-22

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Citations (2)