Machine tools is also called mother machine, and it is the essential equipment in all kinds of manufacturing industry up to automobiles, aircraft and the information terminal. As requirements for machining tools, high rigidity and low thermal expansion is important to perform high-precision machining, and having high damping is necessary to realize high-speed machining. In addition, recently weight saving is also required to allow energy saving. However, since high rigidity and light weight is difficult to achieve both, so this study aims to achieve these requirements by optimize machine tool structure through topology optimization. To verify the result of the optimization, create multiple models to compare new models and previous model in the static rigidity and dynamic rigidity. As a result of analysis, it was found that the new model has 5 times stronger static rigidity than previous model and has high dynamic rigidity.