Elisabeth V. Giger

University Children's Hospital Zurich

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jean‐Christophe Leroux

ETH Zurich

Bastien Castagner

McGill University

Mahmoud Elsabahy

Badr University in Cairo

Robert E. Prud’homme

Université de Montréal

Hui Gao

Tianjin Polytechnic University

Nguyen Tran Nam

Children's Hospital 2

Johanna Räikkönen

University of Eastern Finland

Hans P. Merkle

ETH Zurich

Jukka Mönkkönen

University of Eastern Finland

Bridget Wills

University of Oxford

Cooperative Institutions

Oxford University Clinical Research Unit

University of Oxford

National University Health System

University Hospital Heidelberg

Heidelberg University

Monash University

National University of Singapore

Colorado School of Public Health

University of Basel

Ho Chi Minh City Medicine and Pharmacy University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Gene delivery with bisphosphonate-stabilized calcium phosphate nanoparticles

Journal of Controlled Release (2010)

Elisabeth V. Giger Josep Puigmartí‐Luis Rahel Schlatter Bastien Castagner Petra S. Dittrich

Calcium in biology

10.1016/j.jconrel.2010.11.012

Cite

Citations (118)

Burden of Postinfectious Symptoms after Acute Dengue, Vietnam

Emerging infectious diseases (2023)

Dong Thi Hoai Tam Hannah E. Clapham Elisabeth V. Giger Nguyen Tan Thanh Kieu Nguyen Tran Nam

Abstract We assessed predominantly pediatric patients in Vietnam with dengue and other febrile illness 3 months after acute illness. Among dengue patients, 47% reported >1 postacute symptom. Most resolved by 3 months, but alopecia and vision problems often persisted. Our findings provide additional evidence on postacute dengue burden and confirm children are affected.

10.3201/eid2901.220838

Cite

Citations (4)

Stabilization of calcium phosphate nanoparticles for transfection with nucleic acid drugs

Elisabeth V. Giger

10.3929/ethz-a-007575856

Cite

Citations (1)

Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin

Schweizerische medizinische Wochenschrift (2024)

Verena Gotta Julia Bielicki P Paioni Chantal Csajka Dominic Stefan Bräm

Pharmacometric in silico approaches are frequently applied to guide decisions concerning dosage regimes during the development of new medicines. We aimed to demonstrate how such pharmacometric modelling and simulation can provide a scientific rationale for optimising drug doses in the context of the Swiss national dose standardisation project in paediatrics using amikacin as a case study.

Amikacin

10.57187/s.3632

Cite

Citations (0)

The effect of hyaluronic acid on silk fibroin conformation

Biomaterials (2007)

Marcos Garcia‐Fuentes Elisabeth V. Giger Lorenz Meinel Hans P. Merkle

Fibroin

Biomaterial

10.1016/j.biomaterials.2007.10.024

Cite

Citations (68)

Comment on Shaniv et al. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848

Children (2023)

Elisabeth V. Giger Romy Tilen

We read the article by Shaniv D. et al. entitled "Neonatal Drug Formularies-A Global Scope" [...].

Formulary

Scope (computer science)

10.3390/children10111802

Cite

Citations (2)

siRNA Transfection with Calcium Phosphate Nanoparticles Stabilized with PEGylated Chelators

Advanced Healthcare Materials (2012)

Elisabeth V. Giger Bastien Castagner Johanna Räikkönen Jukka Mönkkönen Jean‐Christophe Leroux

Abstract Despite the enormous therapeutic potential of siRNAs, their delivery is still problematic due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate co‐precipitate has been used for nearly 40 years for in vitro transfection due to its non‐toxic nature and simplicity of preparation. However, rapid particle growth has largely prevented the translation of this method for in vivo purposes. It has recently been shown that bisphosphonate derivatives can physically stabilize calcium phosphate nanoparticles while still allowing for efficient cell transfection with plasmid DNA. Herein, two novel PEGylated chelating agents (PEG‐alendronate and PEG‐inositolpentakisphosphate) with enhanced stabilizing properties are introduced, and it is demonstrated that the bisphosphonate‐stabilized nanoparticles can efficiently deliver siRNA in vitro. The nanoparticles are mainly taken up by clathrin‐dependent endocytosis, and acidification of the endosomal compartment is required to release the entrapped siRNA into the cytosol. Furthermore, particle uptake enhances the inhibition of the mevalonate pathway by the bisphosphonate in macrophages.

10.1002/adhm.201200088

Cite

Citations (59)

Self assembling properties of aminated poly(glycerol methacrylate)s

Journal of Controlled Release (2011)

Hui Gao Mahmoud Elsabahy Elisabeth V. Giger Jianbiao Ma Robert E. Prud’homme

Polyethylenimine

Atom-transfer radical-polymerization

Polynucleotide

Glycidol

10.1016/j.jconrel.2011.08.050

Cite

Citations (3)

Aminated Linear and Star-Shape Poly(glycerol methacrylate)s: Synthesis and Self-Assembling Properties

Biomacromolecules (2010)

Hui Gao Mahmoud Elsabahy Elisabeth V. Giger De‐Kun Li Robert E. Prud’homme

Over the past 10 years, polyglycerols and their structurally related analogs have received considerable attention in the biomedical field. Poly(glycidyl methacrylate) (PGMA) is a versatile polymer because its pendant epoxide groups can be opened with different functional groups to generate poly(glycerol methacrylate)s (PGOHMA) derivatives. In this work, linear and star-shape PGMAs were synthesized by atom transfer radical polymerization and then functionalized with four different amines by ring-opening addition. This resulted in the formation of polyglycerol-like polymers having both hydroxyl and amine moieties and different water-solubility. The water-insoluble polymers could form pH-sensitive nanoassemblies, while the soluble derivatives efficiently complexed a short strand polynucleotide. The aminated polyglycerol interacted more avidly with the oligonucleotide than the control poly(ethyleneimine), and high transfection efficacy could be obtained with the linear derivative. Such polymers could find practical applications for the delivery of drugs and nucleic acids.

Glycidyl methacrylate

Atom-transfer radical-polymerization

Polynucleotide

10.1021/bm901241k

Cite

Citations (62)

Biomedical applications of bisphosphonates

Journal of Controlled Release (2013)

Elisabeth V. Giger Bastien Castagner Jean‐Christophe Leroux

Bone disease

10.1016/j.jconrel.2013.01.032

Cite

Citations (180)