Gila Pirzad Jahromi

Baqiyatallah University of Medical Sciences

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Gholam Hossein Meftahi

Baqiyatallah University of Medical Sciences

Boshra Hatef

Baqiyatallah University of Medical Sciences

Hedayat Sahraei

Baqiyatallah University of Medical Sciences

Seyed Shahabeddin Sadr

Tehran University of Medical Sciences

Mina Mokhtari Hashtjini

Tehran University of Medical Sciences

Shima Shahyad

Baqiyatallah University of Medical Sciences

Mohammadmehdi Hadipour

Baqiyatallah University of Medical Sciences

Alireza Mohammadi

Baqiyatallah University of Medical Sciences

Sara Asalgoo

Tehran University of Medical Sciences

Ali Khaleghi

Fasa University of Medical Sciences

Cooperative Institutions

Baqiyatallah University of Medical Sciences

Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

University of Tehran

Iran University of Medical Sciences

Islamic Azad University, Tehran

Shahid Beheshti University

Mashhad University of Medical Sciences

Tarbiat Modares University

Shiraz University of Medical Sciences

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The Relationship between the Severity of the COVID-19 Disease, Temperament and Psychological Factors

Iranian Journal of Psychiatry (2022)

Ahmad Afzali Hedayat Sahraei Boshra Hatef Gholam Hossein Meftahi Shima Shayad

Objective: The coronavirus (COVID-19) pandemic negatively affects public mental health around the world. Individuals' reactions to COVID-19 vary depending on their temperament, individual differences, and personality traits. Therefore, the current study is conducted to assess the association of demographical features, Persian temperament, and psychological characteristics with the severity of COVID-19. Method: An online survey was sent to COVID-19 patients to collect their demographic information, COVID-19 symptoms, and clinical data. The Depression, Anxiety and Stress Scale (DAAS-21) questionnaire, Beck Depression Inventory (BDI-II), Spiel Berger State-Trait Anxiety Inventory (STAI) , Pittsburgh Sleep Quality Inventory (PSQI), and Persian general and brain temperament Questionnaire were also completed by 258 participants (127 men and 131 women) 45 days after recovery from COVID-19. Non-parametric analysis was used for statistical analysis. Results: Results showed the significant relationship of demographic factors such as weight, age and gender with the severity of the COVID-19 (P < 0.05). Mean scores of brain temperament (warm/cold) in the severe group were significantly lower than the moderate and mild groups (P < 0.05). There was a significant increase in the dry/wet temperament of the brain in the severe and moderate groups compared to the mild group (P < 0.05). The results of DASS-21 showed a significantly higher anxiety in patients with severe COVID-19 compared with moderate and mild groups (P < 0.05). The severe group was found to be significantly different compared to moderate group in the results of BDI-II (P < 0.05). The result of STAI (state and trait) showed a significant difference between the severe group and the mild and moderate groups. The score of PSQI between the moderate and mild groups was significant (P < 0.05). Conclusion: These results indicate the relationship between demographic factors such as weight, age and gender, brain temperament, as well as some psychological factors such as sleep quality and anxiety with the severity of the COVID-19 disease.

Depression

Beck Anxiety Inventory

10.18502/ijps.v17i4.10696

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Citations (2)

Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress

Amino Acids (2024)

Habib Valipour Gholam Hossein Meftahi Gila Pirzad Jahromi Alireza Mohammadi

Abstract Behavioral and functional studies describe hemispheric asymmetry in anxiety and metabolic behaviors in responses to stress. However, no study has reported serotonergic receptor (the 5-HT 1A receptor) lateralization in the basolateral amygdala (BLA) in vivo on anxiety and metabolic behaviors under stress. In the present study, the effect of unilateral and bilateral suppression of the 5-HT 1A receptor in the BLA on anxiety, and metabolic responses to chronic restraint stress was assessed. Male Wistar rats 7 days after cannulation into the BLA received chronic restraint stress for 14 consecutive days. 20 minutes before induction of stress, WAY-100–635 (selective 5-HT 1A antagonist) or sterile saline (vehicle) was administered either uni- or bi-laterally into the BLA. Behavioral (elevated plus maze; EPM, and open field test), and metabolic parameter studies were performed. Results showed that stress causes a significant increase in weight gain compared to control. In the non-stress condition, the left and bilaterally, and in the stress condition the right, left, and both sides, inhibition of 5-HT 1A in the BLA reduced weight gain. In the restraint stress condition, only inhibition of the 5-HT 1A receptor in the left BLA led to decreased food intake compared to the control group. In stress conditions, inhibition of the 5-HT 1A receptor on the right, left, and bilateral BLA increased water intake compared to the stress group. Inhibition of the 5-HT 1A receptor on the left side of the BLA by WAY-100–635 induced anxiety-like behaviors in stressed rats. Similarly, WAY-100–635 on the left BLA effectively caused anxiety-like behaviors in both EPM and open field tests in the control animals. In conclusion, it seems that 5-HT 1A receptors in the left BLA are more responsible for anxiety-like behaviors and metabolic changes in responses to stress.

Basolateral amygdala

Elevated plus maze

5-HT1A receptor

Chronic Stress

10.1007/s00726-023-03380-4

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Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model

Lung (2016)

Maryam Mohammadian Hamid Reza Sadeghipour Iraj Ragerdi Kashani Gila Pirzad Jahromi Abdollah Omidi

Combination therapy

10.1007/s00408-016-9884-1

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Citations (26)

Evaluation of modulatory effects of saffron (Crocus sativus L.) aqueous extract on oxidative stress in ischemic stroke patients: a randomized clinical trial

Nutritional Neuroscience (2020)

Saeed Gudarzi Mahvash Jafari Gila Pirzad Jahromi Reza Eshrati Mostafa Asadollahi

Objectives Saffron (Crocus sativus L.) has been widely used in traditional medicine as a treatment of nervous disorders. Saffron as an antioxidant can be considered effective for treatment of oxidative stress in ischemia stroke. Therefore, the aim of the present study was to investigate the role of aqueous extract of saffron in reducing oxidative stress in ischemic strokes patients.Methods Forty patients with acute ischemic stroke were randomly divided into two groups including control group and saffron group. During 4 days of experiment, control group received routine stroke care and saffron group received routine care plus capsule of saffron 400 mg/day (200 mg twice per day). Then, two groups were compared using the National Institute of Health Stoke Scale (NIHSS) and serum oxidative stress biomarkers, at the time of hospital admission and 4 days later as well.Results On the fourth day after ischemic stroke onset, antioxidant enzymes activities and glutathione (GSH) and total antioxidant capacity (TAC) levels were higher in the saffron group compared to the control group, while malondialdehyde (MDA) level was lower. In addition, the severity of stroke, based on the NIHSS scores, was significantly reduced after 4 days in the saffron group. The severity of stroke was negatively correlated with the levels of GSH and TAC and positively correlated with MDA level.Conclusions Saffron has modulatory effects on ischemic-induced oxidative stress due to its free radical scavenging and antioxidant properties. Thus, saffron extract can be considered as a potential candidate therapy of the ischemic brain.

Malondialdehyde

Stroke

10.1080/1028415x.2020.1840118

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Citations (26)

Effects of systemic and intra-accumbal memantine administration on the impacts of plantar electrical shock in male NMRI mice

Physiology and Pharmacology (2014)

Gholamreza Bagheri Nikoo Maryam Khosravi Hedayat Sahraei Mina Ranjbaran Nahid Sarahian

Introduction: The brain glutamate system plays a central role in response to stress. This study examines the effect of memantine (a NMDA glutamate receptor antagonist) on stress from plantar electrical shock in male NMRI mice (Pasture Institute, Iran), weighing 25-30 g (n=6/group). Methods: The nucleus accumbens was bilaterally cannulated in a group of animals, and seven days later, different doses of memantine (1 and 5 μg/mouse) was administered 5 min before inducing stress. In other groups, different doses of the drug (1 and 5 mg/kg) were administered to the animals intraperitoneally 30 min before the stress induction. Then food and water intake, anorexia, and the amount of urine and fecal materials were measured. Results: The stress reduced food intake and increased water intake in the animals. In addition, anorexia, fecal weight and urine volume were increased dramatically in these animals. Intraperitoneal memantine injection increased food intake and decreased water intake. This occurred when the drug was administered intra-accumbally, too. Memantine inhibited stress-induced anorexia when administered either intraperitoneally or intra-accumbally. Memantine (both peripherally and centrally) also changed stress-induced fecal passage but decreased urination. Conclusion: Memantine administration can inhibit or potentiate stress effects, which may be at least partially integrated in the nucleus accumbens.

Memantine

Anorexia

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Citations (3)

Role of NO-ergic system of the he nucleus accumbens in metabolic disturbances under acute stress

Koomesh Journal (2019)

Yasaman Husseini Alireza Mohammadi Gila Pirzad Jahromi Hedayat Sahraei Boshra Hatef

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Saffron (Crocus sativus) aqueous extract reverses the hypothalamus-pituitary-adrenal axis activity in rat model of post-traumatic stress disorder

Revista Brasileira de Farmacognosia (2019)

Sara Asalgoo Gila Pirzad Jahromi Boshra Hatef Hedayat Sahraei Javad Raouf Sarshoori

Crocus sativus L., Iridaceae, has been used worldwide in traditional medicinefor treatment ofsome neurological disorderssuch as depression. Post-traumatic stress disorder is a mental disorder developed in peoplewho experience stressful events. Since stress has been proposed tocause thehypothalamic-pituitary-adrenal axis malfunction in post-traumatic stress disorder patients, this study aimed at investigating the effect of saffron aqueous extract on hypothalamic-pituitary-adrenal axis activity in rats of post-traumatic stress disorder model. Here, Post-traumatic stress disorder animals received an acute electro foot shock; however, 5 min before the stress session, these animals received an intra-cerebral-ventricular (10 μg/rat) infusion of either saffron aqueous extract or saline. Twenty one days later, they were re-exposedto the stress box withoutinducing stress, andthen were examined for their freezing behavior. The impact of stress and saffron aqueous extract on serum corticosterone, corticotrophin releasing hormone gene expression in hypothalamus and glucocorticoid receptor gene expression in pituitary gland werethen evaluated on day 28. Intra-cerebral-ventricular injection of saffron aqueous extract resulted in an increase in serum corticosterone level and reduced symptoms of freezing behavior, and corticotrophin releasing hormone and glucocorticoid receptor gene expression in post-traumatic stress disorder groups.Saffron administration could improve the symptoms of stress-induced post-traumatic stress disorder, possiblythrough the adjustment ofhypothalamic-pituitary-adrenal axis function.

Corticosterone

Traumatic stress

Corticotropin-releasing hormone

Hypothalamic–pituitary–adrenal axis

10.1016/j.bjp.2019.01.011

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Citations (4)

Impact of the covid-19 pandemic on the psychological status and cortisol level of multiple sclerosis patients

Neuropsychological Rehabilitation (2022)

Boshra Hatef Gila Pirzad Jahromi Gholam Hossein Meftahi Vahid Shaygan Majdedin Ghalavand

This study aimed to compare the changes in psychological status and cortisol level between multiple sclerosis (MS) patients and a healthy control group (HC). One hundred and fifty-five MS patients and 165 HC subjects had completed questionnaires consisting of 36-Item short health survey (SF-36), Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory-II (BDI-II), and fatigue severity score (FSS) before and after (one year from onset) COVID-19 pandemic. The salivary cortisol level was also measured again in 26 MS patients and 14 control individuals. MS patients had lower scores of mental and physical components of quality of life (MCS and PCS), but higher HAM-A, FSS, and BDII scores than HC Before and after COVID-19. There were significant changes in scores of MCS, BDI-II, HAM-A, and FSS after the COVID-19 outbreak in MS patients, but not in PCS score. In HC group, we observed significant changes in scores of MCS, BDI-II, and FSS, but not in scores of PCS and HAM-A. Compared to HC, the MS patients reported greater deterioration in the overall mental health component of their health-related quality of life, and their levels of anxiety and fatigue over the study period. The change of cortisol levels was non-significant with a small effect size.

Beck Anxiety Inventory

Depression

10.1080/09602011.2022.2069825

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Citations (2)

Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis

Acta Histochemica (2022)

Ali Sepehri Gila Pirzad Jahromi Ali Shahbazi Hedayat Sahraei Boshra Hatef

Corticosterone

Pathogenesis

10.1016/j.acthis.2022.151960

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The controlling role of nitric oxide within the shell of nucleus accumbens in the stress-induced metabolic disturbance

Archives of Physiology and Biochemistry (2019)

Yasaman Husseini Alireza Mohammadi Gila Pirzad Jahromi Gholam Hossein Meftahi Hedayat Sahraei

Context and objectives The involvement of the nitricergic system within the shell part of the nucleus accumbens (NAc) was evaluated in the metabolic disturbances due to stress.Materials and methods Male Wistar rats were cannulated in the shell of the left NAc. They received either saline or different doses of L-arginine and/or L-NAME five minutes before each stress session, for four days. Plasma cortisol concentration, food and water intake, time elapsing for eating, animal weight changes and adrenal gland weight were recorded.Results The L-arginine 1 μg/rat decreased the level of cortisol, water and food intake and time of feeding and increased the adrenal weight. But L-NAME at 1 μg/rat had opposite effects on these factors. However, the drugs showed similar effects at 10 μg/rat.Conclusion Injection of nitric oxide modifiers into the left side of NAc shell part may have an interactive role with sub-chronic stress in metabolic behaviour.

10.1080/13813455.2019.1611865

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Citations (1)