Domonkos Sváb

Institute for Veterinary Medical Research

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István Tóth

University of Queensland

Gergely Maróti

HUN-REN Szegedi Biológiai Kutatóközpont

Linda Falgenhauer

University of Giessen

Trinad Chakraborty

University of Giessen

Balázs Horváth

University of Minnesota Medical Center

Manfred Rohde

Helmholtz Centre for Infection Research

Balázs Bálint

HUN-REN Szegedi Biológiai Kutatóközpont

Ulrich Dobrindt

University of Münster

Renáta Kugler

Centre for Agricultural Research

Béla Nagy

University of Debrecen

Cooperative Institutions

Hungarian Academy of Sciences

Institute for Veterinary Medical Research

Centre for Agricultural Research

University of Pecs

Hungarian Research Network

National Food Chain Safety Office

University of Veterinary Medicine

Magyar Agrár- és Élettudományi Egyetem

University of Szeged

Central Veterinary Research Laboratory

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Comparative analysis of the Shiga toxin converting bacteriophage first detected in Shigella sonnei

Infection Genetics and Evolution (2015)

István Tóth Domonkos Sváb Balázs Bálint Maryury Brown-Jaque Gergely Maróti

Prophage

Shigella sonnei

Lysogenic cycle

Podoviridae

10.1016/j.meegid.2015.11.022

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Citations (29)

Citoletális duzzasztó toxinok állatra és emberre patogén Escherichia coliban

Domonkos Sváb István Tóth

Cytolethal distending toxins are widespread bacterial protein toxins which are detected with increasing frequency. CDT production is characteristic in Escherichia coli strains of human and animal origin, both from intestinal and extraintestinal infections. CDT represent a relatively new family of toxins, and there are very few works on the subject written in Hungarian. Therefore in the present work the authors summarize the epidemiology of CDT-producing bacteria with emphasis on E. coli strains, CDT’s mode of action on the cellular level, its role in pathogenesis and the genetic background of its distribution.

Cytolethal distending toxin

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Allelic types of long polar fimbriae in bovine and human Escherichia coli O157 strains

Acta Veterinaria Hungarica (2012)

Domonkos Sváb István Tóth

Long polar fimbriae (Lpf) are recently discovered adhesins and increasingly important genetic markers of pathogenic Escherichia coli strains. The presence and genotype diversity of Lpf operons was screened in a collection of 97 Escherichia coli O157 strains representing different pathotypes, isolated from healthy cattle (n = 43) and human patients (n = 54) in several countries. Individual structural genes of Lpf were scanned by PCR, and allelic variants were detected with a recently developed typing scheme. Ninety-five strains carried at least one whole Lpf operon (genes lpf ABCD and/or lpf ABCDE ). The 64 enterohaemorrhagic (EHEC) and 24 enteropathogenic (EPEC) strains all carried two Lpf operons, allele 3 of lpfA1 and allele 2 of lpfA2 , a combination characteristic of the O157:H7/NM serotype. Out of the 9 bovine atypical (AT; stx-, eae- ) strains, 7 carried one complete Lpf operon, allele 1 of lpfA2 . The atypical strains belonged to main phylogenetic groups A and B1, while the EHEC and EPEC strains were from group D. Lpf variants carried by the 72 strains of the Escherichia coli Reference Collection (ECOR) were determined with the same typing scheme. Alleles were detected in 25 strains, of which 6 were found negative for the respective Lpf operons in earlier studies. The marker value of the Lpf allelic combination for the O157:H7/NM serotype was confirmed, and further evidence was given for the presence of at least two different genetic lineages of atypical bovine E. coli O157 strains.

10.1556/avet.2012.001

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Complete genome sequence of C130_2, a novel myovirus infecting pathogenic Escherichia coli and Shigella strains

Archives of Virology (2018)

Domonkos Sváb Linda Falgenhauer Manfred Rohde Trinad Chakraborty István Tóth

ORFS

Myoviridae

10.1007/s00705-018-4042-0

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R18C is a new viable P2-like bacteriophage of rabbit origin infecting Citrobacter rodentium and Shigella sonnei strains

Archives of Virology (2019)

Domonkos Sváb Balázs Horváth Manfred Rohde Gergely Maróti István Tóth

Abstract Here, we report a novel virulent P2-like bacteriophage, R18C, isolated from rabbit faeces, which, in addition to Escherichia coli K-12 strains, was able to be propagated on Citrobacter rodentium strain ICC169 and a range of Shigella sonnei strains with high efficiency of plating (EOP). It represents the first lytic bacteriophage originating from rabbit and the first infectious P2-like phage of animal origin. In the three characteristic moron-containing regions of P2-like phages, R18C contains genes with unknown function that have so far only been found in cryptic P2-like prophages.

Citrobacter rodentium

Lytic cycle

Shigella sonnei

Prophage

Citrobacter

Siphoviridae

Lysogenic cycle

10.1007/s00705-019-04424-5

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Citations (5)