Manuel Martinez-Albarran

Hospital Civil de Guadalajara

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Fernando Sánchez‐Zubieta

Hospital Civil de Guadalajara

Rogelio Troyo‐Sanromán

Universidad de Guadalajara

Susana del Toro‐Arreola

Universidad de Guadalajara

Jose de Jesus Perez-Molina

Hospital Civil de Guadalajara

Sergio Gallegos‐Castorena

Hospital Civil de Guadalajara

ÓG

Óscar González-Ramella

Hospital Civil de Guadalajara

Jorge Luis Ramírez-Melo

Hospital Civil de Guadalajara

A Angel

Hospital Civil de Guadalajara

Ana L Orozco-Alvarado

Hospital Civil de Guadalajara

Regina M Navarro-Martin del Campo

Hospital Civil de Guadalajara

Cooperative Institutions

Hospital Civil de Guadalajara

Universidad de Guadalajara

Centro de Epilepsia y Neurocirugía Funcional

Oklahoma State University Center for Health Sciences

Hospital Infantil de México Federico Gómez

Centro de Investigación y Proyectos en Ambiente y Desarrollo

Universidad Laica Eloy Alfaro de Manabí

Universidad Autónoma de Nuevo León

Queen's University

Le Cordon Bleu College of Culinary Arts

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PROCALCITONIN AND C-REACTIVE PROTEIN SERUM LEVELS AS MARKERS OF INFECTION IN A PEDIATRIC POPULATION WITH FEBRILE NEUTROPENIA AND CANCER

Pediatric Hematology and Oncology (2009)

Manuel Martinez-Albarran Jose de Jesus Perez-Molina Sergio Gallegos‐Castorena Fernando Sánchez‐Zubieta Susana del Toro‐Arreola

Background: Procalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia. Procedure: Serum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divided into 2 groups, with severe infection (n = 18) or without documented infection (n = 36). Results: Procalcitonin and C-reactive protein were significantly higher in the high-risk group. Procalcitonin displayed 72.2% sensitivity and 80.5% specificity. C-reactive-protein had a sensitivity of 77.7% and specificity of 77.2%. Conclusions: Procalcitonin is an accurate predictor of bacterial infection in neutropenic children, while C-reactive-protein may be a better screening test in emergency settings.

Procalcitonin

Pediatric cancer

10.1080/08880010903044797

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Citations (4)

PROCALCITONIN AND C-REACTIVE PROTEIN SERUM LEVELS AS MARKERS OF INFECTION IN A PEDIATRIC POPULATION WITH FEBRILE NEUTROPENIA AND CANCER

Pediatric Hematology and Oncology (2009)

Manuel Martinez-Albarran Jose de Jesus Perez-Molina Sergio Gallegos‐Castorena Fernando Sánchez‐Zubieta Susana del Toro‐Arreola

Procalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia.Serum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divided into 2 groups, with severe infection (n = 18) or without documented infection (n = 36).Procalcitonin and C-reactive protein were significantly higher in the high-risk group. Procalcitonin displayed 72.2% sensitivity and 80.5% specificity. C-reactive-protein had a sensitivity of 77.7% and specificity of 77.2%.Procalcitonin is an accurate predictor of bacterial infection in neutropenic children, while C-reactive-protein may be a better screening test in emergency settings.

Procalcitonin

Pediatric cancer

10.3109/08880010903044797

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RARE-29. PRIMARY CENTRAL NERVOUS SYSTEM NON-HODGKIN LYMPHOMA IN AN 11-YEAR-OLD BOY: A CASE REPORT

Neuro-Oncology (2020)

Jorge Luis Ramírez-Melo Regina M Navarro-Martin del Campo Manuel Martinez-Albarran Fernando Sánchez‐Zubieta Ana L Orozco-Alvarado

Abstract BACKGROUND Primary central nervous system lymphoma (PCNSL) are very rare in children. CLINICAL CASE: An 11-year-old male presented with a 2 months history with myoclonic movements in the upper right limb, and a sudden frontal headache, gait disturbance due to right hemiparesis and an ipsilateral convulsive episode. Upon admission he had critical condition, with hypertensive skull syndrome, Glasgow of 12, Karnofsky 40%, right hemiparesis, swallowing disorder, facial paralysis, and loss of photo motor reflex and unilateral amaurosis. A CT and MRI showed a huge tumor mass in the left tempo-parietal region, infiltrating the white matter and shifting the midline. A Tumor biopsy was done, and reported diffuse small cell non-Hodgkin lymphoma of high-grade, Burkitt type. Systemic lymphoma workup was negative. He received six cycles of chemotherapy based on high dose methotrexate, rituximab and triple intrathecal.After the second cycle an ophthalmologic evaluation was done, and found infiltration to the right retina, for which 6 cycles of intra vitreous chemotherapy with methotrexate were applied, he showed an excellent response, and recovered all his neurological functions except that right hemianopia persist. Control MRI showed partial response at 2nd cycle and complete response after the 4th cycle. No Radiation was performed. CONCLUSION This report highlights the fact that pediatric PCNSL may be effectively treated by a combination of HDMTX and rituximab-based chemoimmunotherapy without irradiation. Lack of awareness of this rare entity may lead to extense resections of brain, and potential permanent secuelae that were avoided in this illustrative case.

Hemiparesis

10.1093/neuonc/noaa222.739

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