Yukiko Hosono

Hachinohe Gakuin University

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REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer

Lung Cancer (2007)

Yoshihiro Minamiya Hideki Kawai Hajime Saito Manabu Ito Yukiko Hosono

10.1016/j.lungcan.2007.09.012

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Citations (23)

Prognostic significance of serum p53 antibodies in squamous cell carcinoma of the lung.

PubMed (1998)

Takefumi Komiya T. Hirashima M Takada Norikazu Masuda Tsutomu Yasumitsu

The prognostic significance of serum p53-Abs positivity for non-small cell lung cancer (NSCLC) is still unknown.To determine the prognostic value of serum p53-Abs status, we determined serum p53-Abs and immunohistochemistry in 140 patients with stage I-IIIA NSCLC.p53-Abs were detected in 12.1% of all patients and in 17.6% of those with squamous cell carcinoma (SCC). Neither p53-Abs nor p53 overexpression alone was correlated with survival for all patients. When these factors were combined for SCC, seronegative patients with tumors overexpressing p53 survived significantly longer than did those with p53-Abs or p53-nonexpressing tumors. In multivariate analysis, p53-Abs status and p53 overexpression were independent prognostic factors for SCC (p = 0.0337).These findings suggest that the combination of p53Abs seropositivity and p53 overexpression may be a prognostic factor for SCC.

Epidermoid carcinoma

P53 protein

P53 expression

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Citations (22)

[A case of survival--excellent response to chemotherapy in long-term postoperative recurrence of non-small cell lung cancer].

Kazuhiro Imai Yoshihiro Minamiya Hajime Saito Masaji Hashimoto Yoshihiko Kimura

A 63-year-old female underwent lobectomy with ND2a lymph node dissection for left lung cancer in April 1999. Histopathological examination revealed moderately-differentiated adenocarcinoma (pT2N2M0, pStage III A). She received one course of a combination of etoposide (ETP) and cisplatin(CDDP)as adjuvant therapy, followed by oral intake of UFT. At 9 months post-operatively, she received radiation therapy for lymph node recurrence, at which time new multiple lung metastases were found. After receiving 3 courses of a combination of vinorelbine (VNR) and CDDP, a complete response (CR) of all metastatic lesions was achieved. Three years after the original surgery, metastatic lesions recurred, and a total of 9 courses of a combination of VNR and carboplatin (CBDCA) and partial resection of the right lung for pulmonary metastasis were performed in succession. Following this therapy, treatment with gefitinib was initiated for about 6 months, and computed tomography (CT) showed progressive disease. For 8 years following the original operation, the patient received oral chemotherapy using S-1 and has maintained CR on CT. We conclude that oral administration of S-1 is useful as palliative chemotherapy without serious adverse events or worsening of quality of life. Patients like this case are thus able to continue chemotherapy for a long time.

Carboplatin

Vinorelbine

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[Evaluation of Body Temperature during Pancreaticoduodenectomy for Pancreatic Cancer in Elderly Patients Aged over 75 Years Old].

PubMed (2018)

Toru Aoyama Yukiko Hosono Natsuko Ikumi Yasuko Ota Masae Ito

Body temperatures in elderly patients undergoing a pancreaticoduodenectomy(PD)for treatment of pancreatic cancer have not been fully evaluated. We aimed to compare body temperature during a PD between elderly(75 years old)and non-elderly patients.This retrospective study included patients who underwent PD between April 2012 and April 2014 at the Kanasgawa Cancer Center. Patients were categorized into 2 groups: elderly patients(≥75 years of age: group A)and non-elderly patients(<75 years of age: group B). Body temperatures were compared between the groups.We evaluated 58 patients-14 were classified into group A, and 44 into group B. Preoperative clinicopathological outcomes demonstrated no significant differences between patients. A comparison of body temperatures between the groups showed 36.3°C(before surgery)/36.1°C(at 1 hr)/36.3°C(at 2 hr)/36.7°C(at 3 hr)/36.8°C(at 4 hr)/37.1°C(at 5 hr)/37.4°C(at 6 hr)in group A compared to 36.2°C(before surgery)/36.2°C(at 1 hr)/36.4°C(at 2 hr)/36.6°C(at 3 hr)/ 36.9°C(at 4 hr)/37.0°C(at 5 hr)/37.3°C(at 6 hr)in group B. Results did not significantly differ between the groups.Our study suggests that body temperature is not affected by a patient's age.

Group B

Group A

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A Novel Device: The Colon-Air-Discharge-Tube, Is Easier, Safer and Lesser Discomfort to the Patients During Total Colonoscopy

Gastrointestinal Endoscopy (2005)

Nobuyuki Sakurazawa Nobuatsu KOYAMA Naoyuki Yamashita Mutsuya Watanabe Katsumi Maezawa

Cecum

Anal verge

10.1016/s0016-5107(05)01288-5

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Analysis of two patients treated with different anticoagulation therapies for superior pulmonary vein stump thrombosis after left upper lobectomy

The Journal of the Japanese Association for Chest Surgery (2018)

Mariko Takemura Shin‐nosuke Watanabe Yukiko Hosono Masafumi Mitsui

左上葉切除術後に生じた上肺静脈断端内血栓に対して異なる抗凝固療法を用いた2例を報告する．いずれも左上葉肺癌に対して胸腔鏡補助下左上葉切除術を行い，術後1ヵ月よりTegafur/Uracil（UFT）による術後補助化学療法を開始した．症例1では術後4ヵ月，症例2では術後3ヵ月の造影CT検査で左上肺静脈断端内に血栓を指摘され，それぞれWarfarin（Wf）とApixabanによる抗凝固療法を行った．2例とも治療開始から6-8週間後の造影CT検査では血栓が完全に消失し，動脈塞栓症や出血性合併症なく経過した．WfはUFTとの併用で抗凝固作用が増強することが知られており，本症例でも容量調整に難渋した．一方，ApixabanはUFT併用下でも安全に使用することができ，Wfと同等の効果であったことから，UFT内服中の肺静脈断端内血栓における治療オプションとして期待できる．

Tegafur

Apixaban

10.2995/jacsurg.32.203

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Citations (1)

CLINICAL ANALYSIS OF PATIENTS WITH GENERALIZED PERITONITIS OVER EIGHTY YEARS OF AGE.

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2003)

Kazuo Tenma Toshiaki Ichihara Manabu Ito Isao Kikuchi Yukiko Hosono

1992年から2001年までの汎発性腹膜炎手術例は118例あり,このうち80歳以上(高齢者群)の19例と60歳代(対照群)の26例について術前・後の臨床経過,術前合併症および検査成績,手術,術後合併症,予後さらに医療費につき検討した.男女比,原因疾患,術前の経過,術前合併症,検査成績および手術に関する項目では差がみられなかった.術後管理において人工呼吸器の装着を要した例とカテコラミンの投与例,術後譫妄を発症した例が高齢者群で有意に多く,また退院できた症例では高齢者群のみに経口摂取ができず在宅中心静脈栄養または経管栄養となった例が3例あった.手術直接死亡,在院死亡,在院日数および医療費には差がみられなかった.高齢者汎発性腹膜炎の手術においては,術後の呼吸循環管理に重点を置くとともに,譫妄とADL低下の防止に対する精力的なケアが重要であると考えられる.

10.3919/jjsa.64.2095

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Citations (1)

A Clinical Study of 4 Cases of Obstructive Colitis

The Japanese Journal of Gastroenterological Surgery (2002)

Toshiaki Ichihara Kazuo Tenma Hirosi Nanjo M. Itoh Isao Kikuchi

The term “obstructive colitis” refers to ulceroinflammatory lesions occurring in the colon proximal to an obstructive or potentially obstructive lesion. We present 4 cases of obstructive colitis associated with colorectal carcinoma. In all 4 cases, we had difficulty correctly diagnosing the mucosal colon condition and the degree of inflammation observing serosa during surgery. Our cases suggest that the ulceroinflammatory lesion in colonic musosa may be a reversible change, possibly enabling construction of a temporary colostomy to preserve the colon in many few cases. We thus consider that surgical strategies for obstructive colitis require greater analysis.

Proximal colon

Distal colon

10.5833/jjgs.35.673

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Pleural dissemination of esophageal gastrointestinal stromal tumors after an eight-year interval following the primary surgery

General Thoracic and Cardiovascular Surgery (2010)

Kazuhiro Imai Hajime Saito Yoshihiro Minamiya Taku Nakagawa Manabu Ito

Stromal tumor

10.1007/s11748-009-0554-6

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Citations (2)

Subpleural injection of tracer improves detection of mediastinal sentinel lymph nodes in non-small cell lung cancer

European Journal of Cardio-Thoracic Surgery (2007)

Yoshihiro Minamiya Manabu Ito Yukiko Hosono Hideki Kawai Hajime Saito

The advantages and disadvantages of various tracer injection protocols for sentinel lymph node (SLN) mapping have been extensively discussed in relation to breast and gastric cancer. But no such discussion has taken place in relation to SLN mapping in non-small cell lung cancer. We therefore studied the effect of two tracer injection protocols on SLN mapping in patients with non-small cell lung cancer; of particular interest was the relationship between subpleural tracer injection and identification of mediastinal SLNs.A quadrant injection group (n=49) received 1.6 ml of ferucarbotran by peritumoral quadrant injection after thoracotomy. In the subpleural injection group, the same amount of ferucarbotran was injected into the peritumoral quadrants plus the subpleural region (n=27). SLNs were then detected intraoperatively by measuring the magnetic force within lymph nodes using a hand-held magnetometer. After completing the SLN mapping, lobectomy and hilar and mediastinal lymph node dissection was performed.The incidence of mediastinal SLNs was significantly higher in the subpleural injection group (45.4%) than in the quadrant injection group (14.6%) (p=0.007). Moreover, nominal logistic regression analysis revealed subpleural injection to be a significant independent factor contributing to detection of mediastinal SLNs (p=0.024, odds ratio 5.26). In the quadrant injection group, mediastinal lymph node metastasis was detected in two patients thought to have nonmetastatic parenchymal SLNs. By contrast, there were no false-negative cases in the subpleural injection group.Subpleural tracer injection significantly improves detection of mediastinal SLNs in non-small cell lung cancer.

TRACER

10.1016/j.ejcts.2007.07.012

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Citations (16)