Shujuan Guo

State Key Laboratory of Oral Diseases

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Weidong Tian

Sichuan University

Yafei Wu

State Key Laboratory of Oncology in South China

Yi Ding

Sichuan University

Fangjun Huo

Sichuan University

Xinyuan Shi

Inner Mongolia University of Technology

Qian Liu

Sichuan University

Xingxing Dai

Beijing Municipal Education Commission

Shimeng Xiao

Sichuan University

Zhihong Jin

Dalian Maritime University

Weiwei Shi

Shenzhen University

Cooperative Institutions

Sichuan University

State Key Laboratory of Oral Diseases

West China Hospital of Sichuan University

Beijing University of Chinese Medicine

Stomatology Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Capital Medical University

Zhejiang University

Sun Yat-sen University

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Biomimetic Mineralized Hydroxyapatite–Fish-Scale Collagen/Chitosan Nanofibrous Membranes Promote Osteogenesis for Periodontal Tissue Regeneration

ACS Biomaterials Science & Engineering (2024)

Li Mao-xue Guoping Cheng Shimeng Xiao Bo Jiang Shujuan Guo

Commercial mammalian collagen-based membranes used for guided tissue regeneration (GTR) in periodontal defect repair still face significant challenges, including ethical concerns, cost-effectiveness, and limited capacity for periodontal bone regeneration. Herein, an enhanced biomimetic mineralized hydroxyapatite (HAp)-fish-scale collagen (FCOL)/chitosan (CS) nanofibrous membrane was developed. Specifically, eco-friendly and biocompatible collagen extracted from grass carp fish scales was co-electrospun with CS to produce a biomimetic extracellular matrix membrane. An enhanced biomimetic mineralized HAp coating provided abundant active calcium and phosphate sites, which promoted cell osteogenic differentiation, and showed greater in vivo absorption. In vitro experiments demonstrated that the HAp-FCOL/CS membranes exhibited desirable properties with no cytotoxicity, provided a mimetic microenvironment for stem cell recruitment, and induced periodontal ligament cell osteogenic differentiation. In rat periodontal defects, HAp-FCOL/CS membranes significantly promoted new periodontal bone formation and regeneration. The results of this study indicate that low-cost, eco-friendly, and biomimetic HAp-FCOL/CS membranes could be promising alternatives to GTR membranes for periodontal regeneration in the clinic.

Periodontal fiber

10.1021/acsbiomaterials.4c00569

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Citations (1)

[Role of CD(+)4T lymphocyte subsets in the immunopathogenesis of periodontal disease].

PubMed (2013)

Zhenhua Luo Shujuan Guo Jia Yue Yafei Wu

牙周炎是发生于牙周支持组织的慢性炎症破坏性疾病,是引起成年人牙齿丧失的主要原因.牙周炎的发病机制涉及多种因素,以往研究认为牙周致病菌及其产物作为刺激源,通过毒性作用直接引发牙周组织破坏,但是宿主对微生物的过度免疫反应是最终导致牙周组织破坏的主要原因[1].目前研究发现,CD4+T淋巴细胞[又称辅助性T细胞(Thelper cells,Th)]及其分泌的细胞因子亚型的异常表达在牙周炎免疫反应发生中发挥重要作用。

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[Research of induced pluripotent stem cells in oral tissue regeneration].

PubMed (2012)

Su Jiang Shujuan Guo Jiajun Chen

口腔组织缺损给口腔的功能和美观带来了极大的影响[1].组织工程从细胞生物学和分子生物学角度为组织再生提供了一个新的方法.干细胞是一类具有自我复制能力的细胞,在一定条件下可以分化为多种功能的细胞,具有再生出新的组织器官或生物个体的潜在能力.目前用于口腔组织再生的干细胞主要有牙周膜干细胞( periodontal ligamentstem cells,PDLSC)、骨髓基质干细胞(bone marrow stromalstem cells,BMSSC)、牙囊干细胞(dental follicle stem cells,DFSC)、牙乳头干细胞(stem cell from apical papilla,SCAP)、脂肪干细胞( adipose-derived stem cells,ASC)等[2-6].诱导多能干细胞的出现为组织工程的发展提供了新的方向。

10.3760/cma.j.issn.1002-0098.2012.05.017

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Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration

Stem Cell Research & Therapy (2024)

Jiaxiang Zhang Liangrui Chen Jialu Yu Weidong Tian Shujuan Guo

Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and is characterized by the destruction of periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration of the periodontal tissue. Mesenchymal stem cells (MSCs) represent a promising approach to periodontal tissue regeneration. Recently, the prominent role of MSCs in this context has been attributed to microRNAs (miRNAs), which participate in post-transcriptional regulation and are crucial for various physiological and pathological processes. Additionally, they function as indispensable elements in extracellular vesicles, which protect them from degradation. In periodontitis, MSCs-derived miRNAs play a pivotal role in cellular proliferation and differentiation, angiogenesis of periodontal tissues, regulating autophagy, providing anti-apoptotic effects, and mediating the inflammatory microenvironment. As a cell-free strategy, their small size and ability to target related sets of genes and regulate signaling networks predispose miRNAs to become ideal candidates for periodontal tissue regeneration. This review aims to introduce and summarize the potential functions and mechanisms of MSCs-derived miRNAs in periodontal tissue repair and regeneration.

10.1186/s13287-024-03998-5

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Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review)

Molecular Medicine Reports (2020)

Xiuqun Wei Qian Liu Shujuan Guo Yafei Wu

The periodontium is a highly dynamic microenvironment constantly adapting to changing external conditions. In the processes of periodontal tissue formation and remodeling, certain molecules may serve an essential role in maintaining periodontal homeostasis. Wnt family member 5a (Wnt5a), as a member of the Wnt family, has been identified to have extensive biological roles in development and disease, predominantly through the non‑canonical Wnt signaling pathway or through interplay with the canonical Wnt signaling pathway. An increasing number of studies has also demonstrated that it serves crucial roles in periodontal tissues. Wnt5a participates in the development of periodontal tissues, maintains a non‑mineralized state of periodontal ligament, and regulates bone homeostasis. In addition, Wnt5a is involved in the pathogenesis of periodontitis. Recently, it has been shown to serve a positive role in the regeneration of integrated periodontal complex. The present review article focuses on recent research studies of Wnt5a and its functions in development, maintenance, and pathological disorders of periodontal tissues, as well as its potential effect on periodontal regeneration.

Periodontium

WNT5A

Periodontal fiber

Homeostasis

10.3892/mmr.2020.11806

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Wnt5a up-regulates Periostin through CaMKII pathway to influence periodontal tissue destruction in early periodontitis

Journal of Molecular Histology (2021)

Qian Liu Shujuan Guo Ping Huang Liu Li Weiwei Shi

Periostin

Periodontal fiber

WNT5A

10.1007/s10735-021-09975-z

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Multiscale study on the enhancing effect and mechanism of borneolum on transdermal permeation of drugs with different log P values and molecular sizes

International Journal of Pharmaceutics (2020)

Chang Hyun Yang Shujuan Guo Xiaowen Wu Pengshuo Yang Han Lu

10.1016/j.ijpharm.2020.119225

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A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-FU

Ran Wang Zhimin Wu Shufang Yang Shujuan Guo Xing‐Xing Dai

Borneol and menthol were two terpenes wildly used as penetrate enhancer in transdermal drug delivery. To explore their penetration enhancement effect towards hydrophilic drug, 5-FU was selected as model drug. A method combined vitro permeation studies and coarse grain molecular dynamics was used to investigate their penetration enhancement effect towards 5-FU. As a result, although both borneol and menthol showed a penetration enhancement effect towards 5-FU, they differed a lot in the penetration enhancement mechanism, which was also thought to account for their different penetration enhancement effect. As for menthol, SC bilayer disrupting effect seemed to be its main mechanism. While for borneol, its mechanism seemed to be more complicated. Except for disrupting the SC bilayer, it could also increase the permeation of 5-FU by enhancing the diffusion rate of 5-FU or inducing the formation of transient pore. All of this   enable us a molecular understanding of borneol and menthol’s penetration enhancement effect towards hydrophilic drug, which might provide some guidance in the latter research and application.

Borneol

Penetration (warfare)

10.20944/preprints201709.0154.v1

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Citations (3)

[Progress relationship between periostin and periodontitis].

PubMed (2018)

Qian Liu Ping Huang Shujuan Guo

Periostin, a kind of matricellular protein highly expressed in periodontal ligament and periosteum, is an important regulator of the integrity of periodontal ligament and periodontitis processes. Periostin has been shown to play a positive role in the recovery of periodontitis. This paper reviews relevant literature about the role of periostin in periodontal tissue and periodontitis.骨膜蛋白是一种细胞外基质蛋白，主要表达于骨膜与牙周膜等结缔组织，与牙周膜结构和功能的完整性密切相关，对牙周炎的治疗、牙周组织的修复再生有潜在的积极作用。本文对骨膜蛋白与牙周组织及牙周炎的关系进行综述。.

Periostin

Periodontal fiber

Matricellular protein

Periosteum

10.7518/hxkq.2018.06.019

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A novel lamellar structural biomaterial and its effect on bone regeneration

RSC Advances (2020)

Guoping Cheng Shujuan Guo Ningxin Wang Shimeng Xiao Bo Jiang

To evaluate a novel lamellar structural biomaterial as a potential biomaterial for guided bone regeneration, we describe the preparation of a collagen membrane with high mechanical strength and anti-enzyme degradation ability by using the multi-level structure of Ctenopharyngodon idella scales. The physical and chemical properties, in vitro degradation, biocompatibility, and in vivo osteogenic activity were preliminarily evaluated. In conclusion, it was shown that the multi-layered collagen structure material had sufficient mechanical properties, biocompatibility, and osteogenic ability. Meanwhile, it is also shown that there is a gap in current clinical needs, between the guided tissue regeneration membrane and the one being used. Therefore, this study provides useful insights into the efforts being made to design and adjust the microstructure to balance its mechanical properties, degradation rate, and osteogenic activity.

Biomaterial

10.1039/d0ra05760f

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Citations (5)