Qiwen Liu

Guangzhou Medical University

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Co-Authors

Lisheng Liu

Chongqing Cancer Hospital

Dezhi Yang

Xinjiang University

Li Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Xin Lai

Fudan University

Guanhua Du

Henan University

Dianhai Yu

Baidu (China)

Shiying Yang

Chinese Academy of Medical Sciences & Peking Union Medical College

Hai Mei

Wuhan University of Technology

Yang Lü

Chinese Academy of Medical Sciences & Peking Union Medical College

Cheng Xing

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Sciences

Wuhan University of Technology

Shanghai Jiao Tong University

Huazhong University of Science and Technology

Guangzhou Medical University

Chongqing University

Baidu (China)

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Chinese Academy of Sciences

Sun Yat-sen University

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A fuzzy comprehensive evaluation model for harms of computer virus

Cong Zheng Lansheng Han Jihang Ye Mengsong Zou Qiwen Liu

The variety and complexity of virus harm cause there is few practical evaluation methods currently. The paper first presents harms' definition and classification of the virus. Then representative first-level and second-level evaluation indexes are proposed. However, as these evaluation factors could hardly be assigned with definite values and somewhat have fuzziness, the paper constructs a fuzzy evaluation model for the harm of computer virus. Once an obscure value is assigned to each evaluation indexes in the second level, the model can calculate the membership degree to each of the five harm grades, and then obtains a reasonable harm evaluation result. Finally, the paper evaluates the harms of ldquoWorm.WhBoy.hrdquo, ldquoAutoRunrdquo, ldquoJS.Yamanner.ardquo and ldquoAn-ti-virusrdquo by the fuzzy model; the evaluation result is similar to the statistics of the virus.

Computer virus

Value (mathematics)

10.1109/mobhoc.2009.5336930

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Citations (3)

Screening of specific diagnostic peptides of swine hepatitis E virus

Virology Journal (2009)

Kai Zhao Qiwen Liu Ruisong Yu Zhen Li LI Jian-yue

Abstract Background Swine hepatitis E virus (swHEV) is a zoonotic disease that is considered a major problem in pig production and presents a threat to human health. Elucidation of the major antigenic epitopes of swHEV is essential for the effective control of swHEV epidemics. Results By bioinformatic analysis, we identified and then synthesized 12 peptides from open reading frames (ORFs) ORF1, ORF2 and ORF3, including swHEV-1 - swHEV-12. Using the results from ELISA, we selected swHEV-11 as the best candidate antigen and used it as a coating antigen for the development of peptide-based swine anti-HEV ELISA kits. The coefficient of variation (CV) the coefficient of variation (CV) varied between 4.3-7.2% in the same batch, and between 8.2-17.7% in six different batches. When comparing our swine peptide-based kit with the commercial recombinant-based kit, the humane anti-HEV IgG test had a 73.4% correspondence rate for them. Conclusion This is the first systemic study to screen the diagnostic peptides of swHEV and our findings strongly suggest that peptide swHEV-11 is a potent diagnostic reagent of swHEV that could be used in the development of highly efficient diagnostic assays for the specific and highly sensitive detection of anti-HEV activity in swine serum samples.

Hepatitis E Virus

ORFS

Coefficient of variation

10.1186/1743-422x-6-186

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Citations (19)

An improved charge transfer ionic-embedded atom method potential for aluminum/alumina interface system based on damped shifted force method

Computational Materials Science (2016)

Hai Mei Qiwen Liu Lisheng Liu Xin Lai Jun Li

Interface (matter)

Embedded atom model

Aluminum Oxide

Potential method

10.1016/j.commatsci.2015.12.044

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Citations (2)

Design of a 1 × 4 micro-magnetic stimulation device and its targeted, coordinated regulation on LTP of Schaffer-CA1 in the hippocampus of rats

Methods (2024)

Yu Zheng Qiwen Liu Yuhang Zhao Yenan Qi Lei Dong

10.1016/j.ymeth.2024.06.004

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Citations (1)

Construction of Uniform MgO Nanoshells for Improved High-Voltage Performance of Li-Ion Battery

Chemical Communications (2024)

Qiwen Liu Feng Guo Mu‐Yao Qi Amin Cao

A conformal Mg(OH)

Nanoshell

High Voltage

10.1039/d4cc05626d

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Citations (0)

Insights into the Solubility and Structural Features of Four Praziquantel Cocrystals

Crystal Growth & Design (2021)

Qiwen Liu Dezhi Yang Ting Chen Baoxi Zhang Cheng Xing

Cocrystal technology can effectively improve the solubility and other physicochemical properties of compounds. The structural features of cocrystals are the key factors that affect the physicochemical properties. The present study aimed to investigate the solubility of the cocrystals formed between praziquantel and carboxylic acid compounds and understand the structural features of the cocrystals by exploring the intermolecular weak interactions between the components through theoretical computations. Four cocrystals were obtained, and their solubilities were all improved. The structures of the cocrystals were solved for the first time to reveal the structural features. Topology analysis based on the quantum theory of atoms in molecules and electron density difference analysis revealed the existence of classical and nonclassical hydrogen bonds. Energy decomposition analysis based on the symmetry-adapted perturbation theory was further applied to classify and quantify the interaction energy to better understand the composition of the interactions between the components. Notably, the tendency of the endothermic peak values of the cocrystals obtained from thermal analysis was consistent with the tendency of the physical component of maximum classical Coulomb interactions in the energy decomposition analysis and opposite to the tendency of the molecular weight of these cocrystals. In the end, the most promising one of the four cocrystals was selected as a candidate drug after taking into account safety and the improvement of the physicochemical properties.

Cocrystal

Endothermic process

Crystal Engineering

10.1021/acs.cgd.1c00785

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Citations (23)

SERS and RRS Spectral Detection of Ultratrace Sulfite Based on PtPd Nanoalloy Catalytic Amplification

Plasmonics (2020)

Haolin Wang Qiwen Liu Chunqiang Chen Guiqing Wen Aihui Liang

Noble metal

10.1007/s11468-020-01226-3

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Citations (2)

The management effects of Schima superba plantation

Journal of Fujian Forestry Science and Technology (2008)

Qiwen Liu

The analysis of the management effects of Schima superba plantation showed that S.superba had comprehensive adaptability without rigorous site conditions,but prefer to middle and downslope of the site level Ⅰ and Ⅱ;it was suitable for mixed forest rather than pure one which grew slowly and was difficult to become big diameter timber.Its plantation needed to control the density,the proper thinning time,i.e.its density should not be over 975 individuals·hm-2 after 20 years.Within the given density,its DBH,tree height and volume increment decreased along with the increase of the mixed proportion,and the optimal ratio of S.superba to Cunninghamia lanceolata was 4∶6.At the same site condition,the volume and soil fertility of the mixed forest of S.superba and C.lanceolata were higher than that of the pure one.

Cunninghamia

Thinning

Adaptability

Source

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Citations (0)

Plants of the Genus Mahonia as a Potential Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease

Current Topics in Medicinal Chemistry (2023)

Shengfeng Huang Yang Huang Shuo Yang Huikai Shao Xiyu Chen

Alzheimer's disease (AD), a prevalent multiple neurodegenerative disease, has gained attention, particularly in the aging population. However, presently available therapies merely focus on alleviating the symptoms of AD and fail to slow disease progression significantly. Traditional Chinese medicine (TCM) has been used to ameliorate symptoms or interfere with the pathogenesis of aging-associated diseases for many years based on disease-modifying in multiple pathological roles with multi-targets, multi-systems and multi-aspects. Mahonia species as a TCM present potential for anti-inflammatory activity, antioxidant activity, anti-acetylcholinesterase activity, and antiamyloid- beta activity that was briefly discussed in this review. They are regarded as promising drug candidates for AD therapy. The findings in this review support the use of Mahonia species as an alternative therapy source for treating AD.

10.2174/1568026623666230330105251

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Citations (1)

Structural landscape on a series of rhein: Berberine cocrystal salt solvates: The formation, dissolution elucidation from experimental and theoretical investigations

Chinese Chemical Letters (2021)

Dezhi Yang Hongjuan Wang Qiwen Liu Penghui Yuan Ting Chen

Cocrystal

10.1016/j.cclet.2021.10.012

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Citations (29)