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Paolo Angelino

University of Geneva

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Petros Tsantoulis

University of Geneva

Jérôme Tamburini

University of Geneva

Clément Larrue

Inserm

Sarah Mouche

University of Geneva

Jean‐Emmanuel Sarry

Centre de Recherche en Cancérologie de Toulouse

Rudy Birsen

Inserm

François Vergez

Centre Hospitalier Universitaire de Toulouse

Christian Récher

Centre Hospitalier Universitaire de Toulouse

Olivier Kosmider

Assistance Publique – Hôpitaux de Paris

Véronique Mansat‐De Mas

Université de Toulouse

Cooperative Institutions

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

CEA Cadarache

Centre National de la Recherche Scientifique

Institut de Recherche sur la Fusion par Confinement Magnétique

École Polytechnique Fédérale de Lausanne

Culham Science Centre

Max Planck Institute for Plasma Physics

University of Lausanne

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ITER

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First principles based simulations of instabilities and turbulence

Plasma Physics and Controlled Fusion (2004)

L. Ṽillard Paolo Angelino A. Bottino S. Allfrey R. Hatzky

It is now widely believed that low frequency turbulence developing from smallscale instabilities is responsible for the phenomenon of anomalous transport generally observed in magnetic confinement fusion experiments.The microinstabilities are driven by gradients of equilibrium density, ion and electron temperatures and magnetic field strength.Gyrokinetic theory is based on the Vlasov-Maxwell equations and, consistent with the ordering, averages out the fast particle gyromotion, reducing the phase space from 6 to 5 dimensions.Solving the resulting equations is a non-trivial task.Difficulties are associated with the magnetic confinement geometry, the strong disparities in space and time scales perpendicular and parallel to B, the different time scales of ion and electron dynamics, and the complex nonlinear behaviour of the system.The main numerical methods are briefly presented together with some recent developments and improvements to the basic algorithms.Recent results are shown, with emphasis on the roles of zonal E ×B flows, of parallel nonlinearity and of toroidal coupling on the saturation of ion temperature gradient (ITG) driven turbulence in tokamaks.

10.1088/0741-3335/46/12b/005

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Supplementary Table S15 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S15: Relative quantification by lipid class</p>

Vulnerability

10.1158/2159-8290.23618446.v1

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Supplementary Table S11 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S11</p>

Table (database)

10.1158/2159-8290.23579637

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Supplementary Table S6 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S6: Proteomic analysis of FLT3-ITD AML cell lines treated with vehicle or QUIZ</p>

10.1158/2159-8290.23579607.v1

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Supplementary Table S11 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S11</p>

Vulnerability

10.1158/2159-8290.23579637.v1

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Supplementary Table S10 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S10: EnrichR analysis of CEBPA_UP signature</p>

CEBPA

10.1158/2159-8290.23579640.v1

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Supplementary Table S5 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S5: GSEA results in FLT3-ITD PDX AML cells in vivo-treated with GILT or Veh.</p>

10.1158/2159-8290.23579610.v1

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Supplementary Table S4 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S4: GSEA results in FLT3-ITD PDX AML cells ex vivo-treated with QUIZ or Veh.</p>

Ex vivo

10.1158/2159-8290.23579613.v1

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Supplementary Table S7 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S7: Transcriptomics analysis of shCEBPA#2 versus shCTL</p>

10.1158/2159-8290.23641290.v1

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Supplementary Table S1 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in <i>FLT3</i>-Mutant Leukemia

Marie Sabatier Rudy Birsen Laura Lauture Sarah Mouche Paolo Angelino

<p>Table S1: Transcriptome analysis of FLT3-ITD cell lines after FLT3 inhbition</p>

10.1158/2159-8290.23641329

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