Ling-Hua Wei

Fujian Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Wenzhi Guo

First Affiliated Hospital of Zhengzhou University

Tianran Chen

University of Virginia

Hong-Hong Zheng

Fujian Medical University

Hua‐Long Zheng

Fujian Medical University

Guang‐Bo Ge

Shanghai University of Traditional Chinese Medicine

Lili Shen

Union Hospital

Zhen Xue

Fujian Medical University

Ping Li

Fujian Medical University

Chang‐Ming Huang

Fujian Medical University

Binbin Xu

Union Hospital

Cooperative Institutions

Fujian Medical University

Union Hospital

Chinese Academy of Sciences

First Affiliated Hospital of Zhengzhou University

Shanghai University of Traditional Chinese Medicine

Zhengzhou University

Sun Yat-sen University

Dalian Institute of Chemical Physics

Shanghai Jiao Tong University

Fujian Provincial Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Comparison of Short- and Long-Term Outcomes of Robotic Versus Laparoscopic Gastrectomy for cT4a Gastric Cancer: A Multicenter Cohort Study

Hua‐Long Zheng Zhiwei Zheng Hong-Hong Zheng Taiyuan Li Ling-Hua Wei

10.2139/ssrn.5095152

Cite

Citations (0)

Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin

International Journal of Biological Macromolecules (2019)

Ling-Hua Wei Tianran Chen Hongbo Fang Qiang Jin Shuijun Zhang

Hypericin

IC50

Natural product

10.1016/j.ijbiomac.2019.04.181

Cite

Citations (29)

Evaluation of credit value adjustment in K-forward

Insurance Mathematics and Economics (2017)

Xuemiao Hao Chunli Liang Ling-Hua Wei

Longevity Risk

Hedge

Counterparty

Value (mathematics)

10.1016/j.insmatheco.2017.07.004

Cite

Citations (2)

Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies

RSC Advances (2020)

Chengcheng Shi Tianran Chen Qihua Zhang Ling-Hua Wei Chao Huang

Thrombin inhibition therapy is a practical strategy to reduce thrombotic and cardiovascular risks via blocking the formation of blood clots. This study aimed to identify naturally occurring thrombin inhibitors from licorice (one of the most popular edible herbs), as well as to investigate their inhibitory mechanisms. Among all tested licorice constituents, licochalcone A was found as the most efficacious agent against human thrombin (IC50 = 7.96 μM). Inhibition kinetic analyses demonstrated that licochalcone A was a mixed inhibitor against thrombin-mediated Z-Gly-Gly-Arg-AMC acetate hydrolysis, with a Ki value of 12.23 μM. Furthermore, mass spectrometry-based chemoproteomic assays and molecular docking simulations revealed that licochalcone A could bind to human thrombin at both exosite I and the catalytic site. In summary, our findings demonstrated that the chalcones isolated from licorice were a new class of direct thrombin inhibitors, also suggesting that licochalcone A was a promising lead compound for developing novel anti-thrombotic agents.

IC50

Docking (animal)

10.1039/c9ra09203j

Cite

Citations (7)

Prognostic value of preoperative sarcopenia in gastric cancer: A 10-year follow-up study

European Journal of Surgical Oncology (2024)

Hua‐Long Zheng Ling-Hua Wei Bin-Bin Xu Hong-Hong Zheng Zhen Xue

10.1016/j.ejso.2024.108004

Cite

Citations (1)

Preoperative visceral fat area predicts intraoperative adverse events during lymphadenectomy in laparoscopic gastrectomy for gastric cancer: a post hoc analysis

Surgical Endoscopy (2025)

Ling-Hua Wei Hua-Long Zheng Zhi‐Yu Liu Xiao-Qiang Du Chun-Sen Chen

Lymphadenectomy

10.1007/s00464-025-11602-x

Cite

Citations (0)

Research progress on the relationship between thrombin and human diseases

Central Plains Medical Journal (2019)

Ling-Hua Wei Xiao Yu Qiang Jin Tianran Chen Wenzhi Guo

Thrombin is an important serine protease involved in the final step of the coagulation cascade, plays a key role in thrombosis, hemostasis and many other coagulation-related reactions. More and more studies have shown that thrombin is closely related to inflammation, involving nervous, cardiovascular, digestive, respiratory, endocrine, and exercise systems. In this paper, the relevance of thrombin to various human diseases and the underlying mechanisms have been well summarized, all knowledges and information presented here will be very helpful for effective treatments for thrombin-related diseases. Key words: Thrombin; Prothrombin; Coagulation cascade; Inflammation

Coagulation cascade

10.3760/cma.j.issn.1674-4756.2019.08.039

Cite

Citations (0)

Prognostic risk factors for T1 thoracic esophageal cancer: a retrospective cohort study

Translational Cancer Research (2022)

Ling-Hua Wei Chengzhen Xu Longjian Gao Debao Chen Yaxi Duan

Esophageal cancer has a poor overall prognosis and a high incidence of post-treatment complications. This study aimed to analyze the common surgical methods for treating T1 thoracic esophageal cancer and explore its prognostic risk factors to provide a basis for appropriate treatment selection.In this population-based retrospective cohort study, data of patients diagnosed with T1 thoracic esophageal cancer from 2010 to 2016 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were divided according to those who had surgery and those who had radiotherapy. Survival curves were generated using the Kaplan-Meier method and validated by the log-rank test. Cox's regression model was used to analyze the independent prognostic risk factors.Overall, 2,027 eligible patients, including 824 and 1,203 patients in the surgical and non-surgical groups, respectively, were analyzed. There was no significant difference in survival between the surgical and non-surgical groups (P=0.79). In subgroup analysis, the Cox regression analysis showed that radiotherapy was a significant prognostic factor (P=0.00059).The impact of surgery on patients with T1 thoracic esophageal cancer was insignificant; however, radiotherapy was an independent prognostic risk factor. These results provide a reliable basis for clinical treatment of patients with T1 thoracic esophageal cancer.

10.21037/tcr-22-308

Cite

Citations (0)

Biflavones from Ginkgo biloba as inhibitors of human thrombin

Bioorganic Chemistry (2019)

Tianran Chen Ling-Hua Wei Xiao‐Qing Guan Chao Huang Zhe-Yi Liu

Amentoflavone

Ginkgoales

10.1016/j.bioorg.2019.103199

Cite

Citations (71)

Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State

Research Square (Research Square) (2024)

Hua-Long Zheng Zhiwei Zheng Ling-Hua Wei Jia-Bin Wang Jian-xian Lin

Abstract Background and aim: Few studies have investigated the prognostic significance of nutritional indicators in patients with various inflammatory states. Methods Patients who underwent radical gastrectomy for TNM stages I–III gastric cancer were included. Nutritional assessment was performed using commonly used indicators. The patients were categorized into two groups with high and low inflammatory status using the X-tile analysis. Results A total of 1327 patients were enrolled in this study, including 843 and 484 patients in the low- and high-SII groups, respectively. Compared with the SII-low group, the SII-high group exhibited significantly lower GNRI, PNI, CXI, and SMI indices and a higher proportion of patients with malnutrition based on the GLIM and CONUT criteria(all P < 0.05). Multivariate COX analysis revealed that GLIM criteria (overall survival [OS]: P = 0.002; recurrence-free survival [RFS]: P = 0.007) and CONUT (OS: P = 0.010; RFS:P = 0.001) were independent prognostic factors for OS and RFS in the SII-low group. In the SII-high group, the GLIM criteria, GNRI, and SMI were the independent prognostic factors for OS(all P < 0.05), the GLIM criteria and SMI were the independent influencing factors for RFS(all P < 0.05). The TimeROC curve and AUC demonstrated the robustness of the GLIM criteria in predicting prognosis across various inflammatory states. Conclusions Different nutritional indicators should be considered while evaluating the prognosis of patients with gastric cancer with varying inflammatory states. Compared with other nutritional indicators, the GLIM criteria are more suitable for patients with different inflammatory conditions.

Value (mathematics)

10.21203/rs.3.rs-5492406/v1

Cite

Citations (0)