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Objective To study relationship between the form deprivation disease in children and the optical axis.Methods Clinical data in 36 cases form deprivation disease Were retrospective analysis.They were divided into acquired form deprivation disease and congenital form deprivation disease.Results Significant differences were detected in form deprivation.eyes and control eyes.In the acquired form deprivation disease group,form deprivation eyes and pathogenesis had the positive correlation,the difference between form deprivation eyes and control eyes were positive correlate with pathogenesis.In the congenital form deprivation disease group,form deprivation eyes and pathogenesis had the positive correlation,control eyes and pathogenesis had the positive correlation,the difference between form deprivation eyes and control eyes were positive correlate with pathogenesis.Conclusions Unilateral form deprivation in children can prolong optical axis,the longer pathogenesis is the longer optical axis is.
Key words:
Optical axis; Form deprivaton; Children
Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD). Methods: A total of 380 drusen in 45 eyes in 35 patients with the intermediate drusen were longitudinally followed up every 6 months by SD-OCT for a period of 24 months. The drusen were divided into the dynamic group and stable group according to the following parameters: number, volume, concurrent retinal pigment epithelium (RPE)/ellipsoid zone (EZ) damage, and the development of advanced AMD. The morphological characteristics of the progressive or stable drusen were further analyzed. Odds ratios (ORs) and the risk for the drusen progression were calculated. Results: The level of interobserver and intraobserver agreement for each drusen tomographic morphological parameters ranged from 82.7 to 90%. At the end of an average follow-up of 15.92 ± 6.99 months, six patients developed choroidal neovascularization and no patients developed geographic atrophy. Finally, 139 drusen changed and 241 drusen remained stable. The drusen with low reflectivity ( p < 0.001; OR: 5.26; 95% CI: 2.24–12.36), non-homogeneity without a core ( p < 0.001; OR: 4.31; 95% CI: 2.08–8.92), RPE damage ( p < 0.001; OR: 28.12; 95% CI: 9.43–83.85), and the EZ damage ( p < 0.001; OR: 14.01; 95% CI: 5.28–37.18) were significantly associated with active change; the drusen with low reflectivity ( p = 0.01; OR: 2.95; 95% CI: 1.29–6.75) and decreased overlying RPE reflectivity ( p < 0.001; OR: 21.67; 95% CI: 9.20–51.02) were the independent predictors for progression. The drusen with high reflectivity were significantly associated with stabilization ( p = 0.03; OR: 0.17; 95% CI: 0.04–0.84). Conclusion: Spectral-domain optical coherence tomography is an optimized, accurate, and efficient method to follow-up the drusen. The intermediate non-exudative AMD prognosis of the patient was most strongly correlated with the drusen reflectivity and disruption of the overlying RPE layer. The drusen with low reflectivity and overlying RPE damage were more likely to progress and required frequent follow-up.
Objective To observe clinical effect of the Nd∶YAG laser combined with Mitomycin C in treating obstructive disease of the lacrimal duct Methods 128 subjects (143 eyes) with obstructive lesions of the lacrimal duct randomly divided into two groups were treated by WDJ 110 B multipurpose Nd∶YAG laser irradiation 66 subjects (74eyes) in treatment group were irradiated by Nd∶YAG laser and after obstruction relief 0 2 mg/ml Mitomycin C (MMC) was applied to infiltrate the obstruction site for 5 min whereas 62 subjects (69 eyes) in control group were irradiated on obstruction site only Results In treatment group,the cure rates were 8 of 8 eyes (100%) with the obstruction of lacrimal point,9 of 9 eyes (100%) with the obstruction of lacrimal canaliculus,11 of 12 eyes (91 7%) with the obstruction of lacrimal duct and 30 of 45 eyes (66 7%) with the obstruction of nosolacrimal duct,however in control group, the cure rates were respectively 85 7%(6/7),75 5%(6/8),60%(6/10) and 54 5%(24/44) The total cure rate is 60 86%(42/69). The difference between two groups is significant( χ 2=5 206,r=1,P 0 01) Conclusions It is an ideal method for Nd∶YAG laser combined with Mitomycin C in treating obstructive disease of the lacrimal duct comparing with using Nd∶YAG laser merely Mitomycin C and hormone that were used in operation can enhance the effects.
Purpose: To evaluate the treatment solutions and effectiveness of intravitreal ranibizumab (RBZ) or conbercept in patients with wet age-related macular degeneration (wAMD) in a real-life setting in China. Methods: The medical records of 368 patients with wAMD who started RBZ or conbercept treatment between 1 May 2014 and 30 April 2018 were evaluated. All patients were defined on fundus angiography at baseline to determine the subtype of AMD (PCV or CNV). We report visual acuity (VA) and central retinal thickness (CRT) measurements at baseline and 12 months. Results: The average number of anti-VEGF injections was 2.1 ± 1.2. The BCVA improvement of these two groups was similar with a difference of 1.00 letter (95% CI: -1.4~3.4, p = 0.8505). At the end of the study, a BCVA increase of at least 5 letters was determined to be a satisfactory efficacy endpoint. Several factors were related to the possible improvement in the satisfactory efficacy endpoint, including female sex (OR 2.07, 95% CI 1.22~3.51), number of injections (OR 1.40, 95% CI 1.12~1.75) and VA change at the first month (OR 13.75, 95% CI 7.41~25.51). Additionally, some factors were related to the possible reduction in the satisfactory efficacy endpoint, including diabetes (OR 0.27, 95% CI 0.10~0.73) and disease history (OR 0.75, 95% CI 0.57~0.98). Conclusion: Our study demonstrates that anti-VEGF drugs can effectively improve BCVA and reduce CRT in AMD patients. Sex, number of injections, VA change at the first month, diabetes and disease history are the most important factors affecting visual acuity.
Retinopathy of prematurity (ROP) is a vascular proliferative disorder of the developing retina and a significant cause of childhood blindness around the world. The incidence of ROP is affected by many factors, and the incidence rate varies from country to country. The purpose of this study is to report the incidence and risk factors of ROP in neonatal intensive care unit (NICU) of Guangzhou First People's Hospital in China. A retrospective review was performed on 436 premature infants who were consecutive ROP screened in the NICU of Guangzhou First People's Hospital from March 2013 to October 2017. The single-factor analysis and the logistic multivariate regression analysis were used to detect risk factors of ROP. Total 436 premature infants were consecutive ROP screened, 138 (31.65%) were found ROP, and 61(13.99%) were treated. The single-factor analysis revealed that the incidence of ROP was associated with multiple births, gestational age, birth weight, mechanical ventilation, intravascular hemolysis, the number of operations and blood culture results. The logistic multivariate regression analysis revealed that gestational age; birth weight, mechanical ventilation, minimum SaO2 and daily weight gain were independent risk factors for ROP onset. Forty-nine patients underwent retinal laser photocoagulation with recurrence 20 patients. Twelve patients underwent anti-VEGF drug (Ranibizumab) via intraocular injection with 5 patients of recurrence. The incidence of ROP in NICU of Guangzhou China will match those in middle-income countries, but higher than high-income countries. Anti-VEGF drugs could be preferred as a good treatment method for zone 1 ROP and aggressive posterior ROP.
Objective To estimate the validity and security of the optimized project of ORK-CAM guided customized aspheric laser in situ keratomiteusis (LASIK) surgery. Methods Three hundred patients (600 eyes) registered to the Laser Center of The First Municipal People's Hospital of Guangzhou in 2003 and 2008,comparable in mean spherical equivalent and corneal aberration,were randomly assigned to two groups to receive the ORK-CAM guided aspheric customized excimer laser surgery (optimized project group,150 patients,300 eyes) or conventional LASIK surgery (conventional project group,150 patients,300 eyes).Naked eye vision,spherical equivalent,corneal aberration and Q value were measured and compared between the two groups before and 6 months after the surgery. Results Six months after surgery,there were no statistical differences in naked eye vision (P ＞0.05).Both two groups had lowered spherical equivalent but these parameters were not comparable between two groups ifi both absolute value and reduction from baseline (all P ＞0.05).While RMS,RMS3,RMS4,SphA,Coma and Q value increased in both groups.Optimized project group had less increase in these parameters than conventional project group. Conclusion Compared with the conventional spheric surgery,ORK-CAM guided aspheric customized excimer laser surgery can increase the validity and security and improve the visual quality.
Key words:
Laser in situ Keratomileusis; Surgery; Aberrations; Aspheric; Treatment outcome
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