Aya Matsuu

National Institute of Infectious Diseases

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Yoshiaki Hikasa

Tottori University

Hiromi Ikadai

Kitasato University

Makoto Ozawa

Kagoshima University

Tatsunori Masatani

Gifu University

Ken Maeda

National Institute of Infectious Diseases

Masayuki Horie

Osaka Metropolitan University

Kyoko Tsukiyama‐Kohara

Kagoshima University

Takashi Oyamada

Tokushima University

Michiko Harada

Yamaguchi University

Kosuke Okuya

Kagoshima University

Cooperative Institutions

Yamaguchi University

Kagoshima University

Hokkaido University

Tottori University

National Institute of Infectious Diseases

The University of Tokyo

Gifu University

Kitasato University

National Agriculture and Food Research Organization

Obihiro University of Agriculture and Veterinary Medicine

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Sugar Expressions on the Vaginal Epithelium in Pregnant Mice

Journal of Veterinary Medical Science (2012)

Youhei YASUNAGA Takashi Takeuchi Tetsuya Shimokawa Motowo Nabeta Aya Matsuu

Sugar expressions were examined on the epithelium of both the middle portion of the vagina and the vaginal portion of the cervical canal (CC) in pregnant mice to understand the pathogenesis of bacterial infection in the female reproductive organ by using a panel of lectins. As a result, N-acetylglucosamine was positive before pregnant day (P) 7 but negative after P10 and at diestrus on both the vagina and the CC. In addition, some differences in sugar expressions were seen between them. These results suggest that sugar expressions on the mucosal surface would change not only site-specifically but also time-dependently, and these sugar differences indicate the possibility of the alteration of the settled bacterial species on the vaginal mucosa in pregnancy.

Pathogenesis

Sex organ

10.1292/jvms.11-0562

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Citations (0)

The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs

Veterinary Parasitology (2013)

Aiko Iguchi Aya Matsuu Yoshito Fujii Hiromi Ikadai Yoshiaki Hikasa

Atovaquone

Diminazene

10.1016/j.vetpar.2013.06.006

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Citations (11)

PCR-based survey of vector-borne pathogens in dogs in Dhaka, Bangladesh

Journal of the Bangladesh Agricultural University (2013)

MH Talukder Aya Matsuu Aiko Iguchi BC Roy Naohito Nishii

To identify tick-borne pathogens in blood samples from 68 dogs were examined for Babesia, Anaplasma/Ehrichia, Mycoplasma, and Hepatozoon spp. by using a molecular tool. The detection of DNA was performed using specific primers for partial 16S rRNA or 18S rRNA sequence, and amplicon sequences were analyzed. Our investigation detected Babesia gibsoni (26 dogs) and Anaplasma sp. AnHl446 (2 dogs), Mycoplasma haemocanis (27 dogs), and an unknown Mycoplasma spp were detected (2 dogs), which was most closely related to Candidatus Mycoplasma turicensis, on the basis of phylogenetic analysis. Hepatozoon DNA could not be detected in this study.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14915 J. Bangladesh Agril. Univ. 10(2): 249-253, 2012

Hepatozoon

Amplicon

Bartonella

10.3329/jbau.v10i2.14915

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Single Amino Acid Substitution in the Matrix Protein of Rabies Virus Is Associated with Neurovirulence in Mice

Viruses (2024)

Michiko Harada Aya Matsuu Yoshihiro Kaku Akiko Okutani Yusuke Inoue

Rabies is a fatal encephalitic infectious disease caused by the rabies virus (RABV). RABV is highly neurotropic and replicates in neuronal cell lines

Strain (injury)

Incubation period

10.3390/v16050699

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Citations (1)

Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan

Veterinary Microbiology (2019)

Aya Matsuu Yasuyuki Momoi Akihiro Nishiguchi Keita Noguchi Mihoko Yabuki

Lethargy

Case fatality rate

Leukopenia

10.1016/j.vetmic.2019.06.019

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Citations (68)

Prevalence of anti-Toxoplasma gondii antibody in domestic horses in Japan

Parasitology International (2015)

Tatsunori Masatani Yasuhiro Takashima Masaki Takasu Aya Matsuu Tomohiko Amaya

10.1016/j.parint.2015.11.006

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Citations (17)

Establishment of serological neutralizing tests using pseudotyped viruses for comprehensive detection of antibodies against all 18 lyssaviruses

Journal of Veterinary Medical Science (2023)

Yusuke Inoue Yoshihiro Kaku Michiko Harada Keita Ishijima Yudai Kuroda

Rabies is a fatal zoonotic, neurological disease caused by rabies lyssavirus (RABV) and other lyssaviruses. In this study, we established novel serological neutralizing tests (NT) based on vesicular stomatitis virus pseudotypes possessing all 18 known lyssavirus glycoproteins. Applying this system to comparative NT against rabbit sera immunized with current RABV vaccines, we showed that the current RABV vaccines fail to elicit sufficient neutralizing antibodies against lyssaviruses other than to those in phylogroup I. Furthermore, comparative NT against rabbit antisera for 18 lyssavirus glycoproteins showed glycoproteins of some lyssaviruses elicited neutralizing antibodies against a broad range of lyssaviruses. This novel testing system will be useful to comprehensively detect antibodies against lyssaviruses and evaluate their cross-reactivities for developing a future broad-protective vaccine.

Lyssavirus

10.1292/jvms.23-0463

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Detection of feline morbillivirus in cats with symptoms of acute febrile infection

Veterinary Research Communications (2023)

Genta Ito S. Tabata Aya Matsuu Hitoshi Hatai Yuko Goto‐Koshino

Abstract Feline morbillivirus (FeMV) was identified for the first time in cats in 2012 in Hong Kong. Although its association with chronic kidney disease in cats has attracted the attention of researchers, its clinical significance as an acute infection has not been reported. Previously, we reported FeMV detection using next-generation sequence-based comprehensive genomic analysis of plasma samples from cats with suspected acute febrile infections. Here, we conducted an epidemiological survey to detect FeMV by quantitative reverse transcription polymerase chain reaction (qRT-PCR) using blood samples from cats in Japan. FeMV was detected in 32/102 blood samples (31.4%) from cats with suspected acute viral infections. Most of the FeMV-positive cats had clinical findings consistent with acute viral infections, including fever, leukopenia, thrombocytopenia and jaundice. No FeMV was detected in healthy cats or clinically ill cats that visited veterinary hospitals. Phylogenetic analysis classified FeMV L genes into various FeMV subtypes. We also necropsied a FeMV-positive cat that died of a suspected acute infection. On necropsy, FeMV was detected in systemic organs, including the kidneys, lymph nodes and spleen by qRT-PCR and immunohistochemical staining. These results suggest that FeMV infections may cause acute symptomatic febrile infections in cats. A limitation of this study was that the involvement of other pathogens that cause febrile illnesses could not be ruled out and this prevented a definitive conclusion that FeMV causes febrile disease in infected cats. Further studies that include experimental infections are warranted to determine the pathogenicity of FeMV in cats.

Feline infectious peritonitis

Leukopenia

10.1007/s11259-023-10214-x

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Detection and molecular characterization of Babesia sp. in wild boar (Sus scrofa) from western Japan

Ticks and Tick-borne Diseases (2021)

Momoko Morikawa Sumire Mitarai Isshu Kojima Misuzu Okajima Hitoshi Hatai

Wild boar

Domestic pig

10.1016/j.ttbdis.2021.101695

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Citations (4)

IDENTIFICATION OF A NOVEL GENE ENCODING A SECRETED ANTIGEN 1 OF BABESIA GIBSONI AND EVALUATION OF ITS USE IN SERODIAGNOSIS

American Journal of Tropical Medicine and Hygiene (2006)

Honglin Jia Jinlin Zhou Hiromi Ikadai Aya Matsuu Hiroshi Suzuki

Serum from a dog immunized with blood plasma from a B. gibsoni -infected dog, putatively containing secreted antigens, was used to screen a cDNA expression library. A novel gene encoding BgSA1 was identified from the isolated clones. The serum raised in mice immunized with the recombinant BgSA1 expressed in Escherichia coli could recognize a native parasite protein with a molecular mass of 59 kDa. Comparing with the previously established ELISA with recombinant P50 as antigen, the ELISA with recombinant BgSA1 as the antigen was more sensitive when they were used to detect field samples. Moreover, a sandwich ELISA with anti-BgSA1 antibodies could detect the circulating BgSA1 in a serial blood plasma from a dog experimentally infected with B. gibsoni . These results indicated that BgSA1 could be a useful target for the development of a diagnostic test for the detection of specific antibodies and circulating antigens.

10.4269/ajtmh.2006.75.843

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Citations (22)