Toshiaki Kikuchi

Niigata University

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Co-Authors

Satoshi Watanabe

Niigata University

Toshiyuki Koya

Niigata University

Toshihiro Nukiwa

Tohoku University

Akio Hasegawa

National Defense Academy of Japan

Akira Watanabe

Tohoku University

Toshio Tsuchiya

Tokyo University of Marine Science and Technology

Nobumasa Aoki

Niigata University

Toshimitsu Kobayashi

Senshio Rifu hospital

Yasuyoshi Ohshima

Niigata University

Masachika Hayashi

Niigata University

Cooperative Institutions

Children's Defense Fund

847

Istituto Nazionale di Fisica Nucleare

696

Instituto de Física de Cantabria

602

University of Bologna

592

Universidad de Cantabria

591

Fermi National Accelerator Laboratory

531

Tohoku University

399

Academia Sinica

387

University of Florida

337

European Organization for Nuclear Research

332

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Modes and their Phases of Phase Conjugate Waves in Shallow Water

Japanese Journal of Applied Physics (2003)

Takuya Shimura Toshiaki Kikuchi Toshio Tsuchiya

It has been clarified that the phase-conjugate sound waves in the sea converge better than those in free space and that the convergence occurs even in the range over several km, particularly in deep sea. This convergence characteristic is attributed to the sound channel characteristics inherent in sound transmission in the sea. However, the convergence characteristic in shallow water has not been studied, although it is important for the application of phase conjugate waves in underwater acoustic technology. A modal analysis using the Pekeris model of a wave guide in shallow water was performed in order to investigate the convergence mechanism of phase-conjugate waves in shallow water. The sound pressure and phase distributions were obtained for each mode. It appears that all modes concentrate at the focus point, and its phase is zero.

Conjugate

Sound transmission class

10.1143/jjap.42.3216

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Citations (9)

Does the gut microbiota play a key role in PD-1/PD-L1 blockade therapy?

Translational Lung Cancer Research (2020)

Satoshi Watanabe Toshiaki Kikuchi

Cancer Therapy

10.21037/tlcr.2020.03.31

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Citations (4)

Retrospective efficacy analysis of immune checkpoint inhibitors in patients with EGFR‐mutated non‐small cell lung cancer

Cancer Medicine (2019)

Tadaaki Yamada Soichi Hirai Yuki Katayama Akihiro Yoshimura Shinsuke Shiotsu

Abstract Background Treatment with epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) leads to initial response in most patients with EGFR ‐mutated non‐small cell lung cancer (NSCLC). In contrast, little is known of the subpopulation of patients with NSCLC with EGFR mutations who exhibit clinical outcomes that require treatment with immune checkpoint inhibitors (ICIs). Therefore, to identify eligible cases to treat with ICIs, we retrospectively analyzed the correlation between clinical features and the efficacy of ICIs in patients with EGFR mutations. Patients and Methods We retrospectively analyzed patients with advanced NSCLC harboring EGFR mutations who were treated with ICIs after developing resistance to EGFR‐TKIs between February 2016 and April 2018 at 6 institutions in Japan. The association between clinical outcomes and the efficacy of ICIs was investigated. Results We enrolled 27 patients who harbored EGFR ‐activating mutations. The objective response and disease control rates were higher in patients with uncommon EGFR mutations than in those with common EGFR mutations (71% vs 35.7% and 57% vs 7%, P = 0.14 and P < 0.01, respectively). Patients with uncommon EGFR mutations or without T790M mutations exhibited a significantly longer median progression‐free survival than those with common EGFR mutations or with T790M mutations ( P = 0.003 and P = 0.03, respectively). Conclusion Patients with uncommon EGFR mutations and without T790M mutations are associated with the best outcomes for treatment with immunotherapy among those with EGFR ‐mutated NSCLC, based on retrospective analysis. Further research is needed to validate the clinical biomarkers involved in ICI responders with EGFR mutations.

T790M

EGFR Inhibitors

10.1002/cam4.2037

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Citations (93)

Antigen-pulsed dendritic cells expressing macrophage-derived chemokine elicit Th2 responses and promote specific humoral immunity

Journal of Clinical Investigation (2001)

Toshiaki Kikuchi Ronald G. Crystal

Macrophage-derived chemokine (MDC) is a potent chemoattractant for antigen-specific T lymphocytes. We hypothesized that Adenovirus- (Ad-) transduced dendritic cells (DCs) overexpressing MDC would enhance the T cell–mediated humoral immune response specific for antigens presented by the DC. We challenged two strains of mice with lethal Pseudomonas aeruginosa infection 3 weeks after immunization with AdMDC-modified DCs pulsed with heat-killed P. aeruginosa. MDC-expressing DCs specifically attracted T lymphocytes and preserved typical DC surface phenotypes without growth factors in vitro. Mice immunized with AdMDC/Pseudomonas/DCs developed high levels of serum anti-Pseudomonas Ab’s and were protected from a lethal respiratory challenge with Pseudomonas. The in vivo protective immunity required CD4+ T cells, B cells, and IL-4, but not CD8+ T cells and IL-12. AdMDC/DCs pulsed with Pseudomonas yielded significant but not absolute cross-protection against different strains of P. aeruginosa. Pseudomonas-pulsed AdMDC/DCs protected mice from Pseudomonas but not Escherichia coli and vice versa; this microbe-specific protection correlated with microbe-specific induction of CD4+ T cell proliferation and IL-4 secretion. Based on these observations, AdMDC-modified DCs pulsed with a killed bacteria may be a useful approach to vaccination against infectious disorders.

10.1172/jci200111564

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Citations (36)

Combined PARP and PD-L1 inhibition: a promising treatment option for relapsed small-cell lung cancer

Journal of Thoracic Disease (2024)

Naohiro Yanagimura Satoshi Watanabe Toshiaki Kikuchi

10.21037/jtd-24-269

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Citations (0)

Low Frequency Ambient Noise Measurement in Sagami Bay

The Journal of the Marine Acoustics Society of Japan (2007)

Ryoichi Iwase Jun Naoi Toshiaki Kikuchi Koichi Mizutani

For the purpose of monitoring deep seafloor environmental changes associated with a submarine earthquake swarm, a cabled observatory consisting of multidisciplinary sensors including a hydrophone was deployed by JAMSTEC at a depth of 1200 m off Hatsushima Island in Sagami Bay. By using the data obtained by the observatory, the relationship between surface weather changes and underwater ambient noise, especially the origin of low frequency noise lower than 100 Hz, was examined. As a result, the site effects on the noise characteristics obtained by the hydrophone, consisting of the surrounding topography and the water depth, became clear. It also became clear that the low frequency noise caused by an earthquake and a typhoon can be discriminately observed by the observatory. These results can be utilized for detecting fluctuation phenomena or precursors on the seafloor that are associated with earthquakes.

Hydrophone

Ambient noise level

Typhoon

Seafloor Spreading

10.3135/jmasj.34.87

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Seamount effects on long range acoustic propagation in the West Pacific

T. Tsuchiya Jun Naoi Hirohisa Saito Toshiaki Kikuchi

Acoustical oceanography depends highly on identification of eigen rays and accurate measurement of arrival times of the incoming rays. In particular, it is the case for the long-range propagation at the SOFAR (SOund Fixing and Ranging) channel. However, there are several candidates for disturbing the incoming wave trains such as internal waves, ocean currents and scattering at a seamount. We perform a series of numerical simulations of the long-range acoustic propagation to evaluate the scattering at a seamount. We find that even if the top of the seamount is 2000 m below the SOFAR axis, strong scattered signals still comes up to the arrival record at the SOFAR axis. This shows the possibility that scattered signals at the ocean bottom contaminate the wave trains recorded at the SOFAR axis

Seamount

10.1109/oceans.2004.1406472

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Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells

Stem Cells (2007)

Hong Xin Masahiko Kanehira Hiroyuki Mizuguchi Takao Hayakawa Toshiaki Kikuchi

MSCs are nonhematopoietic stem cells capable of differentiating into various mesoderm-type cells. MSCs have been considered to be a potential vehicle for cell-based gene therapy because MSCs are relatively easily expanded in vitro and have the propensity to migrate to and proliferate in the tumor tissue after systemic administration. Here, we demonstrated the tropism of mouse MSCs to tumor cells in vitro and multiple tumor tissues in the lung after i.v. injection of green fluorescent protein-positive MSCs in vivo. We transduced CX3CL1 (fractalkine), an immunostimulatory chemokine, to the mouse MSCs ex vivo using an adenoviral vector with the Arg-Gly-Asp-4C peptide in the fiber knob. Intravenous injection of CX3CL1-expressing MSCs to the mice bearing lung metastases of C26 and B16F10 cells strongly inhibited the development of lung metastases and thus prolonged the survival of these tumor-bearing mice. This antitumor effect depended on both innate and adaptive immunity. These results suggest that MSCs can be used as a vehicle for introducing biological agents into multiple lung tumor tissues. Disclosure of potential conflicts of interest is found at the end of this article.

CX3CL1

Systemic administration

Ex vivo

10.1634/stemcells.2006-0461

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Citations (164)

Development of a simple reprocessing process using selective precipitant for uranylions — Engineering studies on systems for precipitating and separating

Progress in Nuclear Energy (2005)

Kazuhiko Yamasaki Takahiro Chikazawa Yoshihisa Tamaki Toshiaki Kikuchi Masatoshi Hanzawa

Separator (oil production)

Human decontamination

10.1016/j.pnucene.2005.05.041

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Citations (4)

Characteristics of M-Sequence Signal in an Inhomogeneous Medium

Japanese Journal of Applied Physics (1999)

Kohji Futa Nobuaki Takahashi Nobuaki Takahashi Toshiaki Kikuchi Hiroshi Ochi Hiroshi Ochi

One often observes fluctuation or disappearance of pulses in a series of received signals in the ocean. In ocean acoustic tomography (OAT), pulses are detected with cross-correlation coefficients between a received signal and the replica of a transmitted M-sequence signal. We study the influence of phase variation of an M-sequence signal on the coefficients through computer simulation. It is found that the coefficients rapidly become small as the phase shift increases. As a result, we should consider phase shift of signals in the analysis of received pulses in OAT.

SIGNAL (programming language)

Sequence (biology)

10.1143/jjap.38.3154

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Citations (0)