Mara Manghi

Health Center

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Taha Hirbod

Karolinska University Hospital

Jan Andersson

Karolinska Institutet

Lucia Lopalco

Vita-Salute San Raffaele University

Caterina Uberti‐Foppa

Eni (Italy)

Kristina Broliden

Karolinska University Hospital

Marco Vinceti

University of Modena and Reggio Emilia

Francesca Bonvicini

University of Bologna

Sonia Andersson

Karolinska Institutet

Daniela Mecugni

University of Modena and Reggio Emilia

Nicola Leone

University of Modena and Reggio Emilia

Cooperative Institutions

Karolinska University Hospital

Karolinska Institutet

University of Modena and Reggio Emilia

Istituti di Ricovero e Cura a Carattere Scientifico

Azienda Sanitaria Unità Locale di Reggio Emilia

GTx (United States)

Vita-Salute San Raffaele University

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

University of Toronto

Johns Hopkins University

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L’effetto di una strategia per migliorare la compliance degli immigrati ‘irregolari’allo screening per la tubercolosi in un ambulatorio di Reggio Emilia

Assistenza infermieristica e ricerca (2008)

Nicola Leone Francesca Bonvicini Rossano Fornaciari Marina Greci Mara Manghi

L’infezione tubercolare latente (ITL) nella popolazione extracomunitaria ‘irregolare’ presente in Italia rappresenta un importante problema di sanita pubblica. Obiettivo. In questo lavoro vengono descritti i risultati di una diversa organizzazione dell’ambulatorio del Centro per la salute della famiglia straniera di Reggio Emilia. Metodo. Nell’ambulatorio e stato inserito un infermiere dedicato che si occupa dello screening e del follow-up dei pazienti, in stretta collaborazione con un mediatore culturale. E stata valutata l’aderenza allo screening da parte degli immigrati. Risultati. Sui 177 pazienti che hanno avuto accesso all’ambulatorio 12 (6.7%) hanno rifiutato di eseguire la Mantoux. Tra i 165 soggetti che hanno eseguito il test, 147 (89%) si sono ripresentati entro 3-4 giorni. Solo 16 (10.8%) erano stati sollecitati telefonicamente. La compliance e risultata notevolmente piu elevata rispetto all’anno precedente (89% vs 68%). Conclusioni. L’introduzione di un infermiere dedicato ed il miglioramento della comunicazione possono contribuire a migliorare la compliance dei pazienti

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Upregulation of Interferon-?? and RANTES in the Cervix of HIV-1-Seronegative Women With High-Risk Behavior

JAIDS Journal of Acquired Immune Deficiency Syndromes (2006)

Taha Hirbod Jakob Nilsson Sonia Andersson Caterina Uberti‐Foppa Davide Ferrari

Objective: The expression of innate immune molecules associated with potential blocking activity of HIV-1 propagation was analyzed in the cervical tissue of a group of African HIV-1 IgG-negative commercial sex workers (CSWs) with an HIV-1-encountering risk behavior. Methods: Cervical biopsies from the superior portion of the ectocervix were assessed for innate immune molecules and evaluated in situ by computerized image analysis at the single-cell level. Results: A higher expression of interferon-α (IFNα) and RANTES was detected in CSWs and HIV-1-infected individuals as compared to low-risk HIV-1-uninfected controls (Neg Ctrls). Most (>90%) of RANTES-expressing cells were CD8+ cells as determined by confocal microscopy. In contrast, the expression of leukemia inhibitory factor (LIF) and secretory leukocyte protease inhibitor (SLPI) was comparable between the groups. The expression of β-defensin 2 was highest in HIV-1-infected individuals. Conclusions: Induction of IFNα and RANTES expression in cervical mucosa may contribute to protection of sexual HIV-1 transmission in subjects with a higher risk behavior.

SLPI

10.1097/01.qai.0000229016.85192.60

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The effect of a strategy to improve adherence of irregular non UE citizens to tuberculosis screening in a clinic of Reggio Emilia

Nicola Leone Francesca Bonvicini Rossano Fornaciari Marina Greci Mara Manghi

UNLABELLED Latent tubercolar infection in irregular non EU-citizens in Italy is an important issue of public health. Aim of this paper is to describe the effects of a new organization of the Centre for the health of foreign families of Reggio Emilia. METHOD A dedicated nurse, responsible of patients' screening and follow-up, in strict collaboration with a cultural interpreter were made available. Patients adherence to the screening was measured. RESULTS On 177 eligible patients, 12 (6.7%) refused the Mantoux text. Over the 165 screened patients, 147 (89%) returned to the clinic after 3-4 days. Only 16 (10.8%) needed a phone reminder. Adherence to the screening improved remarkably compared to the previous year (89% vs 68%). CONCLUSIONS A dedicated nurse and the improvement of communication may contribute to improve patients compliance.

Health centre

Public health nurse

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Abundant and Superficial Expression of C-Type Lectin Receptors in Ectocervix of Women at Risk of HIV Infection

JAIDS Journal of Acquired Immune Deficiency Syndromes (2009)

Taha Hirbod Tove Kaldensjö Lucia Lopalco Elin Klareskog Sonia Andersson

Dendritic cells (DCs) are among the first cells to encounter HIV after mucosal exposure and can bind virus via C-type lectin receptors (CLRs). Here, we characterized the distribution of various DC subtypes and the density of the CLRs, DC-SIGN, langerin, and mannose receptor in the ectocervix of HIV-seronegative women with low- and high-risk behavior for acquiring HIV.Cryosections from ectocervical biopsies, collected from sexually active low-risk healthy HIV immunoglobulin G-negative women (n = 10) and HIV immunoglobulin G-negative commercial sex workers (n = 8), were assessed by computerized image analysis.We identified various distinct DC populations. CD11c(-)CD1a(+)langerin(+) cells were localized in the epithelium, whereas CD11c(+)CD1a(-)DC-SIGN and CD11c(-)CD1a(-)CD68(+)DC-SIGN(+)mannose receptor(+) cells were restricted to the lamina propria of the ectocervix. CD123(+) cells were found at low incidence and did not express any of the investigated CLRs. The density of CLR expression was significantly higher in the high-risk as compared with the low-risk women.The superficial and abundant presence of potential HIV target cells makes the ectocervix a likely site for HIV transmission. The detected variations in density and localization of potential HIV receptors should be considered when developing topical prophylactic measures.

Langerin

Mannose receptor

DC-SIGN

Lamina propria

CD11c

C-type lectin

10.1097/qai.0b013e3181a74f89

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Citations (40)