Anastasia Uvarova

D. Mendeleyev University of Chemical Technology of Russia

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Natalia Menshutina

D. Mendeleyev University of Chemical Technology of Russia

Maria Mochalova

D. Mendeleyev University of Chemical Technology of Russia

Olga Abramova

Federal Medical Research Centre for Psychiatry and Narcology

Pavel Tsygankov

D. Mendeleyev University of Chemical Technology of Russia

Daria Lovskaya

D. Mendeleyev University of Chemical Technology of Russia

Eugene Zubkov

Federal Medical Research Centre for Psychiatry and Narcology

Igor Lebedev

MIREA - Russian Technological University

ОИ

О. И. Гурина

Federal Medical Research Centre for Psychiatry and Narcology

Ruslan R. Safarov

D. Mendeleyev University of Chemical Technology of Russia

Valeria Ushakova

Federal Medical Research Centre for Psychiatry and Narcology

Cooperative Institutions

D. Mendeleyev University of Chemical Technology of Russia

Federal Medical Research Centre for Psychiatry and Narcology

Ministry of Health of the Russian Federation

Moscow Research and Clinical Center for Neuropsychiatry

Pirogov Russian National Research Medical University

Russian Academy of Sciences

Federal Center Research Fundamentals of Biotechnology

Moscow State University

Lomonosov Moscow State University

Mental Health Commission

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Gels (2022)

Natalia Menshutina Alexander G. Majouga Anastasia Uvarova Daria Lovskaya Pavel Tsygankov

The nasal drug delivery route has distinct advantages, such as high bioavailability, a rapid therapeutic effect, non-invasiveness, and ease of administration. This article presents the results of a study of the processes for obtaining chitosan aerogel particles that are promising as nasal or inhalation drug delivery systems. Obtaining chitosan aerogel particles includes the following steps: the preparation of a chitosan solution, gelation, solvent replacement, and supercritical drying. Particles of chitosan gels were obtained by spraying and homogenization. The produced chitosan aerogel particles had specific surface areas of up to 254 m2/g, pore volumes of up to 1.53 cm3/g, and porosities of up to 99%. The aerodynamic diameters of the obtained chitosan aerogel particles were calculated, the values of which ranged from 13 to 59 µm. According to the calculation results, a CS1 sample was used as a matrix for obtaining the pharmaceutical composition "chitosan aerogel-clomipramine". X-ray diffraction (XRD) analysis of the pharmaceutical composition determined the presence of clomipramine, predominantly in an amorphous form. Analysis of the high-performance liquid chromatography (HPLC) data showed that the mass loading of clomipramine was 35%. Experiments in vivo demonstrated the effectiveness of the pharmaceutical composition "chitosan aerogel-clomipramine" as carrier matrices for the targeted delivery of clomipramine by the "Nose-to-brain" mechanism of nasal administration. The maximum concentration of clomipramine in the frontal cortex and hippocampus was reached 30 min after administration.

10.3390/gels8120796

Cite

Citations (7)

Biopolymer aerogels as nasal drug delivery systems

Сверхкритические флюиды. Теория и практика. (2023)

Natalia Menshutina Anastasia Uvarova Maria Mochalova Д.Д. Ловская Pavel Tsygankov

Получены микрочастицы аэрогеля на основе яичного белка и хитозана, характеризующиеся низкой плотностью, развитой морфологией и высокой удельной площадью поверхности, высокой пористостью, большим объемом и малым диаметром пор. Методом лазерной дифракции получены кривые распределения частиц по размерам, из которых были рассчитаны среднечисленный и аэродинамический диаметры. Аэродинамический диаметр всех полученных биополимерных аэрогелей лежит в диапазоне, необходимом для осуществления адресной доставки активных фармацевтических ингредиентов (АФИ) в обонятельную область носовой полости. Проведены экспериментальные исследования по внедрению АФИ «мелатонин» в поры биополимерных аэрогелей на стадии замены растворителя и методом сверхкритической адсорбции. Методом высокоэффективной жидкостной хроматографии определены массовые доли АФИ в полученных фармацевтических композициях «биополимерный аэрогель — АФИ». Методом рентгенофазового анализа показано, что АФИ в фармацевтических композициях присутствует преимущественно в аморфном состоянии. Результаты экспериментальных исследований in vivo показали, что в случае интраназального введения обеих композиций «биополимерный аэрогель — АФИ» максимальная концентрация АФИ в тканях мозга достигается уже через 30 мин. Это доказывает, что полученные биополимерные аэрогели на основе белка и хитозана перспективны для использования в качестве матриц-носителей АФИ при разработке назальных систем их доставки. Protein (egg white) and chitosan aerogel microparticles characterized by low density, developed morphology and high specific surface area, high porosity, large volume and small pore diameter, were obtained. Using the laser diffraction method, particle size distribution curves were obtained, from which the average number and aerodynamic diameters were calculated. The aerodynamic diameter of all obtained biopolymer aerogels lies in the range required for targeted delivery of active pharmaceutical ingredients (APIs) to the olfactory region of the nasal cavity. Experimental studies have been carried out on the introduction of API «melatonin» into the pores of biopolymer aerogels at the stages of solvent replacement and supercritical adsorption. Mass fractions of API in the resulting pharmaceutical compositions «biopolymer aerogel — API» were determined by high-performance liquid chromatography. X-ray powder diffraction showed that API in pharmaceutical compositions is present mainly in the amorphous state. The results of in vivo experimental studies showed that in the case of intranasal administration of both «biopolymer aerogel — API» compositions, the maximum concentration of API in brainтtissues is reached after 30 minutes. This proves that the resulting biopolymer aerogels based on protein (egg white) and chitosan are promising for use as API carrier matrices in the development of nasal drug delivery systems.

Biopolymer

10.34984/scftp.2023.18.1.001

Cite

Citations (0)

Biopolymer Aerogels as Nasal Drug Delivery Systems

Russian Journal of Physical Chemistry B (2023)

Natalia Menshutina Anastasia Uvarova Maria Mochalova Daria Lovskaya Pavel Tsygankov

Biopolymer

10.1134/s1990793123070163

Cite

Citations (1)

Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems

Pharmaceuticals (2024)

Ruslan R. Safarov О. В. Федотова Anastasia Uvarova М. Г. Гордиенко Natalia Menshutina

In recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous system (CNS) disorders, and vaccine delivery. The nasal cavity possesses a unique set of anatomical characteristics for delivering active pharmaceutical ingredients, but there are several limitations that recent research in the field of the intranasal administration of APIs aims to overcome. For the effective delivery of nasal preparations, active pharmaceutical ingredients are incorporated into various micro- and nanosystems. Some of the most commonly encountered API delivery systems in the scientific literature include liposomal systems, polymer particles with mucoadhesive properties, in situ gels, nano- and microemulsions, and solid lipid particles. This article provides a review of research on the development of nasal preparations for treating local nasal cavity diseases (in particular, for antibiotic delivery), systemic diseases (analgesics, drugs for cardiovascular diseases, antiviral and antiemetic drugs), CNS disorders (Alzheimer’s disease, Parkinson’s disease, epilepsy, schizophrenia, depression), and vaccine delivery. The literature data show that active research is underway to reformulate drugs of various pharmacotherapeutic groups into a nasal form.

Solid lipid nanoparticle

Delivery system

10.3390/ph17091180

Cite

Citations (0)

Information-Analytical Software for Developing Digital Models of Porous Structures’ Materials Using a Cellular Automata Approach

Technologies (2023)

Igor Lebedev Anastasia Uvarova Natalia Menshutina

An information-analytical software has been developed for creating digital models of structures of porous materials. The information-analytical software allows you to select a model that accurately reproduces structures of porous materials—aerogels—creating a digital model by which you can predict their properties. In addition, the software contains models for calculating various properties of aerogels based on their structure, such as pore size distribution and mechanical properties. Models have been implemented that allow the description of various processes in porous structures—hydrodynamics of multicomponent systems, heat and mass transfer processes, dissolution, sorption and desorption. With the models implemented in this software, various digital models for different types of aerogels can be developed. As a comparison parameter, pore size distribution is chosen. Deviation of the calculated pore size distribution curves from the experimental ones does not exceed 15%, which indicates that the obtained digital model corresponds to the experimental sample. The software contains both the existing models that are used for porous structures modeling and the original models that were developed for different studied aerogels and processes, such as the dissolution of active pharmaceutical ingredients and mass transportation in porous media.

10.3390/technologies12010001

Cite

Citations (1)

Active Pharmaceutical Ingredients Transportation and Release from Aerogel Particles Processes Modeling

Computation (2022)

Igor Lebedev Anastasia Uvarova Maria Mochalova Natalia Menshutina

In this work, active pharmaceutical ingredients release from aerogel particles and active pharmaceutical ingredients transportation processes were investigated. Experimental studies were carried out on the release of various types of active pharmaceutical ingredients from various types of aerogel particles. Release curves were obtained. A hybrid model using the lattice Boltzmann method and a cellular automata approach to simulate the release of active pharmaceutical ingredients from aerogel particles and active pharmaceutical ingredients transport processes is proposed. The proposed model can be used in new drug development, which allows partially replacing full-scale experiments with computational ones, therefore reducing the experimental studies cost.

Active principle

Lattice Boltzmann methods

10.3390/computation10080139

Cite

Citations (5)