Naresh Jindal

Lala Lajpat Rai University of Veterinary and Animal Sciences

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Sagar M. Goyal

University of Minnesota

N. K. Mahajan

Lala Lajpat Rai University of Veterinary and Animal Sciences

Sunil K. Mor

University of Minnesota

Yogesh Chander

National Research Centre on Equines

Dinesh Mittal

Lala Lajpat Rai University of Veterinary and Animal Sciences

Devi P. Patnayak

University of Minnesota

Vivek Kapur

Pennsylvania State University

Renu Gupta

Lala Lajpat Rai University of Veterinary and Animal Sciences

Ramesh Kumar

Lala Lajpat Rai University of Veterinary and Animal Sciences

Andre F. Ziegler

University of Minnesota

Cooperative Institutions

Lala Lajpat Rai University of Veterinary and Animal Sciences

Indian Veterinary Research Institute

Indian Council of Agricultural Research

Pennsylvania State University

National Research Centre on Equines

University of Minnesota

Chaudhary Charan Singh Haryana Agricultural University

Guru Angad Dev Veterinary and Animal Sciences University

Kerala Veterinary and Animal Sciences University

University of Veterinary and Animal Sciences

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Diminution of aflatoxin B1 toxicity in broilers by dietary Supplementation of lysine, methionine and choline chloride

The Indian Journal of Animal Sciences (1994)

Naresh Jindal S. K. Mahipal N. K. Mahajan

Choline chloride

Choline

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Citations (3)

Isolation and genetic characterization of swinepox virus from pigs in India

Comparative Immunology Microbiology and Infectious Diseases (2016)

Thachamvally Riyesh Sanjay Barua Naveen Kumar Naresh Jindal Bidhan Chandra Bera

Isolation

Virus isolation

Genetic Analysis

10.1016/j.cimid.2016.04.001

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Citations (12)

Occurrence of Marek`s Disease in Vaccinated Poultry Flocks of Haryana (India)

International Journal of Poultry Science (2007)

KAMALDEEP KAMALDEEP Prakash Chand Sharma Naresh Jindal G. Narang

Marek's Disease (MD), which is a lymphoproliferative disease of chickens, remains one of th e most important diseases. In the present study, occurrence of Marek's disease virus in ten vaccinated poultry flocks of Haryana (India) from different geographical locations was determined on the basis of clinical signs, gross and histopathology and precipitation test. The vaccines used were either HVT alone or in combination with SB-1. Samples from all the flocks had gross and histopathological lesions suggestive of Marek' s disease. Grossly, visceral tumors in liver, spleen, kidney and ovary were observed. The characteristic histopathological lesions included infiltration of pleomorphic lymphoid cells such as lymphoblasts, small and large lymphocytes, plasma cells and occasionally MD cells in different organs. The lesions were non- capsulated and infiltrative type. In immunodiffusion test, feather follicle tip samples from five flocks gave a positive precipitation reaction.

Flock

Marek's disease

10.3923/ijps.2007.372.377

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Citations (20)

Enteric viruses in chicken enteritis

Journal of Antivirals & Antiretrovirals (2015)

Naresh Jindal

Enteric virus

Enteric fever

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Molecular characterization of chicken astroviruses in gout-affected commercial broiler chickens in Haryana, India

VirusDisease (2019)

Sumitra Panigrahi Naresh Jindal Pawan Kumar Sanjay Barua Naveen Kumar

Embryonated

Flock

10.1007/s13337-019-00554-1

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Citations (9)

Detection and molecular characterization of enteric viruses from poult enteritis syndrome in turkeys

Poultry Science (2010)

Naresh Jindal Devi P. Patnayak Yogesh Chander Andre F. Ziegler Sagar M. Goyal

This study was conducted to detect and characterize enteric viruses [rotavirus, turkey astrovirus-2 (TAstV-2), reovirus, and turkey coronavirus] from cases of poult enteritis syndrome (PES) in Minnesota turkeys. Of the intestinal contents collected from 43 PES cases, 25 were positive for rotavirus and 13 for small round viruses by electron microscopy (EM). Of the enteric virus-positive cases by EM (n=27), 16 cases had rotavirus or small round viruses alone and the remaining 11 cases had both viruses. None of the cases were positive for reovirus or coronavirus by EM. However, with reverse transcription-PCR (RT-PCR), 40 cases (93%) were positive for rotavirus, 36 (84%) for TAstV-2, and 17 (40%) for reovirus. None of the cases were positive for turkey coronavirus by RT-PCR. The viruses from all cases were detected either alone or in combination of 2 or 3 by RT-PCR. Thus, 8 (19%) cases were positive for a single virus, whereas a combination of viruses was detected in the remaining 35 (81%) cases. The rota-TAstV-2 combination was the most predominant (n=18 cases). Fifteen cases were positive for all 3 viruses. The rotaviruses had sequence homology of 89.8 to 100% with previously published sequences of turkey rotaviruses at the nucleotide level. The TAstV-2 had sequence homology of 84.6 to 98.7% with previously published TAstV-2, whereas reoviruses had sequence homology of 91.6 to 99.3% with previously published sequences of turkey reoviruses. Phylogenetic analysis revealed that rota- and reoviruses clustered in a single group, whereas TAstV-2 clustered in 2 different groups. In conclusion, a larger number of PES cases was positive for rotavirus, TAstV-2, and reovirus by RT-PCR than with EM. The presence of more than one virus and changes at the genetic level in a virus may affect the severity of PES in turkey flocks.

10.3382/ps.2009-00424

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Citations (86)

Retrospective Study on Epidemiology of Infectious Bursal Disease in Broiler Chickens in Haryana, India

International Journal of Current Microbiology and Applied Sciences (2018)

Pooja Kundu G. Narang N. K. Mahajan Priyanka Yadav Naresh Jindal

A retrospective study was conducted to understand the epidemiology of infectious bursal disease (IBD) in broiler chicken flocks in Haryana state. The epidemiological data related to IBD outbreaks for the period from January 2008 to June 2016 was analyzed. A total of 1368 outbreaks of IBD occurred during this period with overall morbidity, mortality and case fatality rate of 4.19%, 2.61% and 62.34% respectively. The disease was recorded throughout the year with maximum outbreaks in August month and in quarter July to September. Out of 1368 IBD outbreaks, maximum number of 734 (53.7%) IBD outbreaks were reported in 21-30 days of age followed by 349 (25.5%) in 11-20 days of age, 259 (18.9%) in 31-40 days of age and 26 (1.9%) outbreaks in 41-50 days of age. This indicates an increase in number of IBD outbreaks in 11-20 days of age cases as compared to earlier reports. Out of total IBD outbreaks, 918 were recorded in vaccinated flocks while 450 were in unvaccinated flocks. The case fatality rate was higher in unvaccinated flocks. Concurrent diseases were recorded in 627 IBD affected flocks. Pneumonia, coccidiosis, respiratory disease complex (RDC), E. coli infection, mycotoxicosis, Ranikhet disease and heat stroke were the major concurrent diseases. Improper immunization schedule, unhygienic conditions on the farm, emergence of newer strains of IBD virus, interference or absence of maternal antibodies could be the reasons for disease in vaccinated flocks. Continuous study may help in better understanding of infectious bursal disease in broiler chickens in this region.

Infectious bursal disease

Flock

Case fatality rate

10.20546/ijcmas.2018.706.150

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Citations (6)

Molecular characterization of quail bronchitis virus isolated from bobwhite quail in Minnesota

Poultry Science (2016)

Azad Singh Aschalew Z. Bekele Devi P. Patnayak Naresh Jindal Robert E. Porter

From 2008 to 2012, 4 separate cases of quail bronchitis virus infection were seen in bobwhite quail (Colinus virginianus) raised in Minnesota. The quail chicks ranged in age from 5 d to 8 wk and suffered from respiratory distress and elevated mortality. On necropsy, gross lesions consisted of mucus in trachea, congested lungs, caseous air sacculitis, accumulation of chalky white urates on internal organs, necrotic foci in liver, and enlarged spleen. Histologic examination revealed fibrinoheterophilic rhinitis, heterophilic bronchitis, heterophilic tracheitis, and interstitial pneumonia in addition to deciliation, desquamation, and necrosis of bronchial respiratory epithelium. Karyomegaly with basophilic intranuclear inclusions was also seen in affected epithelium. Severe epicarditis, pericarditis, myocarditis, multifocal necrotizing hepatitis, and splenitis were additional pathological findings. Quail bronchitis virus (QBV) was isolated from all four samples when inoculated in specific-pathogen-free (SPF) embryonated chicken eggs. The virus was confirmed by electron microscopy and polymerase chain reaction using fowl adenovirus (FAdV) hexon gene-specific primers. Nucleotide sequences of the four isolates showed 99.0% identity with CELO strain of fowl adenovirus A. Nine nucleotide substitutions were observed; 3 of these were nonsynonymous (A281G, C314T and G565C), leading to changes in deduced amino acid sequences (S94G, T105M and A189P, respectively). Based on partial sequence of the hexon gene, QBV isolates of this study clustered closely with fowl adenovirus A and were different from FAdV groups B through E and from adenoviruses of goose, duck, turkey, and pigeon. Further studies are indicated to determine the impact of nonsynonymous substitutions on host specific pathogenicity of these viruses.

Colinus

Bobwhite quail

Embryonated

Air sacs

Tracheitis

Basophilic

10.3382/ps/pew217

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Citations (11)

Detection of Infectious Bursal Disease Virus in Field Outbreaks in Broiler Chickens by Reverse Transcription-Polymerase Chain Reaction

International Journal of Poultry Science (2005)

Dinesh Mittal Naresh Jindal S.L. Gupta .R. S. Kataria A. Tiwari

During the period from July 2002 to June 2003, infectious bursal disease (IBD) was suspected in 101 commercial flocks of broiler chickens on the basis of clinical and post mortem findings in som e districts of the Haryana state, India. Bursal samples were collected randomly from 20 flocks for the detection of infectious bursal disease virus (IBDV) by reverse transcription- polymerase chain reaction (RT-PCR) and nested PCR assay. IBDV could be detected in 17 samples as evidenced by amplification of 643 bp fragment of the very variable region of VP2 gene of virus by agarose gel electrophoresis. The authenticity of th e amplicons was further confirmed by nested PCR generating amplicons of 552 bp using internal primers. The results of the present study indicated that RT-PCR followed by nested PCR can be used to diagnose field outbreaks of IBD in poultry because of its rapidity, accuracy and sensitivity.

Infectious bursal disease

10.3923/ijps.2005.239.243

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Citations (15)

A Defined Antigen Skin Test for Diagnosis of Bovine Tuberculosis in Domestic Water Buffaloes (Bubalus bubalis)

Frontiers in Veterinary Science (2021)

Tarun Kumar Mahavir Singh Babu Lal Jangir Devan Arora Sreenidhi Srinivasan

Bovine tuberculosis (bTB) remains endemic in domestic water buffaloes ( Bubalus bubalis ) in India and elsewhere, with limited options for control other than testing and slaughter. The prescribed tuberculin skin tests with purified protein derivative (PPD) for diagnosis of bTB preclude the use of Bacille Calmette-Guérin (BCG)-based vaccination because of the antigenic cross-reactivity of vaccine strains with Mycobacterium bovis and related pathogenic members of the M. tuberculosis complex (MTBC). For the diagnosis of bTB in domestic water buffaloes, we here assessed a recently described defined-antigen skin test (DST) that comprises overlapping peptides representing the ESAT-6, CFP-10 and Rv3615c antigens, present in disease-causing members of the MTBC but missing in BCG strains. The performance characteristics of three doses (5, 10 or 20 μg/peptide) of the DST were assessed in natural tuberculin skin test reactor ( n = 11) and non-reactor ( n = 35) water buffaloes at an organized dairy farm in Hisar, India, and results were compared with the single intradermal skin test (SIT) using standard bovine tuberculin (PPD-B). The results showed a dose-dependent response of DST in natural reactor water buffaloes, although the SIT induced a significantly greater ( P < 0.001) skin test response than the highest dose of DST used. However, using a cut-off of 2 mm or greater, the 5, 10, and 20 μg DST cocktail correctly classified eight, 10 and all 11 of the SIT-positive reactors, respectively, suggesting that the 20 μg DST cocktail has a diagnostic sensitivity (Se) of 1.0 (95% CI: 0.72–1.0) identical to that of the SIT. Importantly, none of the tested DST doses induced any measurable skin induration responses in the 35 SIT-negative animals, suggesting a specificity point estimate of 1.0 (95% CI: 0.9–1.0), also identical to that of the SIT and compares favorably with that of the comparative cervical test (Se = 0.85; 95% CI: 0.55–0.98). Overall, the results suggest that similar to tuberculin, the DST enables sensitive and specific diagnosis of bTB in water buffaloes. Future field trials to explore the utility of DST as a defined antigen replacement for tuberculin in routine surveillance programs and to enable BCG vaccination of water buffaloes are warranted.

Bubalus

Water buffalo

Mycobacterium tuberculosis complex

10.3389/fvets.2021.669898

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Citations (4)