Mingdang Li

Nanjing University of Posts and Telecommunications

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Yueyun Li

Shandong University of Technology

Yunhui Dong

Shandong University of Technology

Qiang Zhao

Nanjing University of Posts and Telecommunications

Shujuan Liu

Nanjing University of Posts and Telecommunications

Faying Li

University of Jinan

Jinhui Feng

University of Jinan

Tao Lang

Shenzhen University

Haichao Zhou

Shenzhen University

Menglong Zhao

Wuhan University of Technology

Fenglan Li

Shanxi Medical University

Cooperative Institutions

Shandong University of Technology

Nanjing University of Posts and Telecommunications

Shenzhen University

Chinese Academy of Sciences

Nanjing Tech University

City University of Hong Kong

The Synergetic Innovation Center for Advanced Materials

Zhejiang University

Peking University

Nanjing University

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Rational Design of Near-Infrared-Absorbing Pt(II)-Chelated Azadipyrromethene Dyes as a New Generation of Photosensitizers for Synergistic Phototherapy

Inorganic Chemistry (2020)

Mingdang Li Yunjian Xu Menglong Zhao Feiyang Li Wei Feng

Pt(II) photosensitizers are emerging as novel Pt anticancer agents for cancer photodynamic therapy (PDT) to avoid uncontrollable toxicity of cisplatin. However, the application of Pt(II) photosensitizers is limited by tumor hypoxia and the poor penetration depth of excitation light. To overcome these drawbacks, exploiting the next generation of Pt anticancer agents is of urgent need. According to theoretical calculations, novel near-infrared (NIR)-absorbing Pt(II)-chelated azadipyrromethene dyes (PtDP-X, where X = N, C, and S) were designed. Importantly, spin–orbit coupling of the Pt atom could promote the intersystem crossing of a singlet-to-triplet transition for converting oxygen to singlet oxygen (1O2), and the azadipyrromethene skeleton could provide a strong photothermal effect. As expected, PtDP-X exhibited intense NIR absorption and synergistic PDT and photothermal effects with low dark cytotoxicity. Furthermore, water-soluble and biocompatible PtDP-N nanoparticles (PtDP-N NPs) were prepared that achieved effective tumor cell elimination with low side effects under 730 nm light irradiation in vitro and in vivo. This pioneering work could push the exploitation of NIR-absorbing metal-chelated azadipyrromethene dyes, so as to promote the positive evolution of phototherapy agents.

Intersystem crossing

HeLa

10.1021/acs.inorgchem.0c02631

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Rational Design of Efficient Organic Phototherapeutic Agents via Perturbation Theory for Enhancing Anticancer Therapeutics

ChemMedChem (2019)

Yunjian Xu Menglong Zhao Licai Wu Feiyang Li Mingdang Li

Abstract The development of efficient phototherapeutic agents (PTA) through rational and specific principles exhibits great potential to the biomedical field. In this study, a facile and rational strategy was used to design PTA through perturbation theory. According to the theory, both the intersystem crossing rate for singlet oxygen generation and nonradiative transition for photothermal conversion efficiency can be simultaneously enhanced by the rational optimization of donor–acceptor groups, heavy atom number, and their functional positions, which can effectively decrease the energy gap between the singlet and triplet states and increase the spin‐orbit coupling constant. Finally, efficient PTA were obtained that showed excellent performance in multimode‐imaging‐guided synergetic photodynamic/photothermal therapy. This study therefore expands the intrinsic mechanism of organic PTA and should help guide the rational design of future organic PTA via perturbation theory.

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10.1002/cmdc.201900302

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Rational Design of Near‐Infrared Aza‐Platinum‐Dipyrromethene‐Based Nanophototherapy Agent with Multistage Enhancement for Synergistic Antitumor Therapeutics

Small Structures (2021)

Yunjian Xu Menglong Zhao Yucheng Zhou Jiawei Wang Mingdang Li

The development of innovative synergistic phototherapy (SPT) agent with excellent photodynamic therapy (PDT) and photothermal therapy (PTT) effects for efficient antitumor is of great significance. However, the low photothermal conversion efficiency or low singlet oxygen yield of SPT agent during the phototherapy process will result in inefficient tumor therapy. Herein, a new near‐infrared (NIR) SPT agent based on aza‐platinum‐dipyrromethene dye ( D‐3 ) with synergistic PDT and PTT effects is rationally designed and synthesized by the metallization and halogenation of aza‐dipyrromethene simultaneously. The introduction of iodine atoms and Pt(II) ion to aza‐dipyrromethene skeleton can not only effectively promote the excited electrons to undergo intersystem crossing process for improving singlet oxygen ( 1 O 2 ) generation capability, but also inhibit radiative transition process for boosting photothermal conversion properties. For biological exploration, the biocompatible D‐3 nanomaterials (APIDNs) with excellent concentration‐dependent photoacoustic and photothermal properties are prepared, thus visibly guiding synergetic PDT and PTT effects for inhibiting the growth of tumor cells in vivo. This work demonstrates the superior therapy effects of APIDNs and its negligible dark cytotoxicity. The novel strategy reported in this work will offer a new way to design new‐generation NIR aza‐metal‐dipyrromethene‐based dyes for developing superior SPT agents.

Rational design

Intersystem crossing

10.1002/sstr.202100094

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白金ナノワイヤ埋込み球状SBA‐15ミクロスフェアと統一2層金膜の信号増幅システムに基づく超高感度サンドイッチ型電気化学免疫センサとチオニン【Powered by NICT】

Biosensors and Bioelectronics (2017)

Ping Wang Mingdang Li Pei Fubin Yueyun Li Liu Qing

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Sandwich-type amperometric immunosensor using functionalized magnetic graphene loaded gold and silver core-shell nanocomposites for the detection of Carcinoembryonic antigen