Anal fissure is a common ailment, however, the pathophysiology and optimal treatment strategy is unclear. Anal fissures may be classified as acute or chronic. Acute fissures are effectively treated and prevented with conservative measures, whereas chronic fissures typically require medical or surgical therapy. Invasive interventions have superior healing rates compared with local medical therapies, but may cause persistent incontinence. New interventions are constantly introduced and may be of value in patients with high risk of incontinence, but more evidence is currently needed.

Anal fissure

Pathophysiology

Conservative Treatment

Medical Therapy

Medical treatment

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Lateral internal sphincterotomy (LIS) using endoanal ultrasound ‐ a video vignette

Colorectal Disease (2021)

Helene Perregaard Kikke Bartholin Hagen Peter‐Martin Krarup Andreas Nordholm‐Carstensen

The data that support the findings of this study are available from the corresponding author upon reasonable request. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Vignette

10.1111/codi.15900

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Citations (1)

Fistula Laser Closure (FiLaC™) for fistula-in-ano—yet another technique with 50% healing rates?

International Journal of Colorectal Disease (2021)

Andreas Nordholm‐Carstensen Helene Perregaard Kikke Bartholin Hagen Peter‐Martin Krarup

Fistulotomy

Single Center

10.1007/s00384-021-03932-8

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Citations (19)

Cancer characteristics, prognoses and mortality of colorectal cancer in patients with Crohn’s disease – A Danish nationwide cohort study, 2009-2019

Journal of Crohn s and Colitis (2024)

Martha Pollen Johansen Mads Damsgaard Wewer Peter‐Martin Krarup Johan Burisch Andreas Nordholm‐Carstensen

Investigate the impact of Crohn's Disease (CD) on patient- and cancer characteristics and mortality in patients with colorectal cancer (CRC).

Interquartile range

10.1093/ecco-jcc/jjae153

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Indeterminate Pulmonary Nodules at Colorectal Cancer Staging: A Systematic Review of Predictive Parameters for Malignancy

Annals of Surgical Oncology (2013)

Andreas Nordholm‐Carstensen Peer A Wille-Jørgensen Lars N. Jørgensen Henrik Harling

Indeterminate

Surgical oncology

10.1245/s10434-013-3062-y

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Citations (42)

PET/CT i opfølgningen af patienter opereret for kolorektalcancer

Ugeskrift for Læger (2016)

Anne Fogh Hansen Mads Radmer Jensen Andreas Nordholm‐Carstensen

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[Laparoscopy can be used to diagnose peritoneal tuberculosis].

PubMed (2014)

Jakob F. Schwensen Mustafa Bulut Andreas Nordholm‐Carstensen

A 17-year-old man with weight loss, abdominal pain and fever for three months was admitted to the Digestive Disease Centre. Laboratory tests revealed leucocytosis and a low haemoglobin level, and a CT-scan of the abdomen indicated non-specific abscess cavities. Diagnostic laparoscopy was conducted and widespread pale nodules were found throughout the peritoneum. Consequently, the patient was diagnosed with peritoneal tuberculosis. This case demonstrates that atypical manifestations of tuberculosis exist in Denmark and that laparoscopy with biopsy can be performed to obtain the diagnosis when suspecting peritoneal tuberculosis.

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Anastomotic Leak Increases Distant Recurrence and Long-Term Mortality After Curative Resection for Colonic Cancer

Annals of Surgery (2013)

Peter‐Martin Krarup Andreas Nordholm‐Carstensen Lars N. Jørgensen Henrik Harling

To investigate the impact of anastomotic leak (AL) on disease recurrence and long-term mortality in patients alive 120 days after curative resection for colonic cancer.There is no solid data as to whether AL after colonic cancer surgery increases the risk of disease recurrence.This was a nationwide cohort study of 9333 patients, prospectively registered in the database of the Danish Colorectal Cancer Group and merged with data from the Danish Pathology Registry and the National Patient Registry. Multivariable Cox regression analysis was used to adjust for confounding.The incidence of AL was 6.4%, 744 patients died within 120 days. Of the remaining 8589 patients, 861 (10.0%) developed local recurrence with no association to AL [adjusted hazard ratio (HR) = 0.78; 95% confidence interval (CI): 0.55-1.12; P = 0.184]. Distant recurrence developed in 1281 (14.9%) patients and more frequently after AL (adjusted HR = 1.42; 95% CI: 1.13-1.78; P = 0.003). AL was also associated with increased long-term mortality (adjusted HR = 1.20; 95% CI: 1.01-1.44; P = 0.042). In 2841 patients with stage III cancer, AL was associated with both decreased likelihood of receiving adjuvant chemotherapy (adjusted HR = 0.58; 95% CI: 0.45-0.74; P < 0.001) and a delay to initial administration (16 days; 95% CI: 12-20 days; P < 0.001).AL was significantly associated with increased rates of distant recurrence and long-term all-cause mortality. Cancelled or delayed administration of adjuvant chemotherapy may partly account for these findings.

10.1097/sla.0b013e3182a6f2fc

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Citations (243)

Robot-assisted TAMIS: a systematic review of feasibility and outcomes

Surgical Endoscopy (2023)

Peter Jakobsen Peter‐Martin Krarup Kristian K. Jensen Andreas Nordholm‐Carstensen

10.1007/s00464-022-09853-z

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Citations (12)