Maryam Khoshbakht Pishkhan

University of Social Welfare and Rehabilitation Sciences

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Sogand Vahidi

Kermanshah University of Medical Sciences

Vida Baloui Jamkhaneh

Islamic Azad University, Babol

Seyedeh Elham Norollahi

Semnan University of Medical Sciences

Majid Alipour

Islamic Azad University, Babol

Afshin Shafaghi

Guilan University of Medical Sciences

Mohammad Namayan Marghoob

Shahid Beheshti University of Medical Sciences

Maryam Foumani

Guilan University of Medical Sciences

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Guilan University of Medical Sciences

Islamic Azad University, Babol

Kermanshah University of Medical Sciences

Ardabil University of Medical Sciences

Semnan University of Medical Sciences

Babol University of Medical Sciences

Payame Noor University

Islamic Azad University, Science and Research Branch

University of Tehran

Razi Hospital

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DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer

Oman Medical Journal (2021)

Seyedeh Elham Norollahi Maryam Foumani Maryam Khoshbakht Pishkhan Afshin Shafaghi Majid Alipour

Epigenetic modifications, particularly DNA methylation, is commonplace and a remarkable factor in carcinogenesis transformation. Conspicuously, previous findings have presented a cluster of irregular promoter methylation alterations related with silencing of tumor suppressor genes, little is accepted regarding their sequential DNA methylation (hypo and hyper) modifications during the cancer progression. In this way, fluctuations of DNA methylation of many genes, especially MYC, SMAD2/3, and DNMT3A, have an impressive central key role in many different cancers, including colorectal cancer (CRC). CRC is distinguished by DNA methylation, which is related to tumorigenesis and also genomic instability. Importantly, molecular heterogeneity between multiple adenomas in different patients with CRC may show diverse developmental phenotypes for these kinds of tumors. Conclusively, studying factors that are involved in CRC carcinogenesis, especially the alterations in epigenetic elements, such as DNA methylation besides RNA remodeling, and histone modification, acetylation and phosphorylation, can be influential to find new therapeutic and diagnostic biomarkers in this type of malignancy. In this account, we discuss and address the potential significant methylated modifications of these genes and their importance during the development of CRC carcinogenesis.

Cancer Epigenetics

Epigenomics

10.5001/omj.2020.93

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