The basal adenylate cyclase activity of the bovine adrenal medullais similar to that of the adrenal cortex. The medullary enzyme is less responsive in vitro to stimulation by optimal fluoride ion concentrations (8 HIM), and is not elevated by ACTH. Medullary adenylate cyclase activity is also unaffected by carbamylcholine, nerve-growth factor, prostaglandin E1, or dexamethasone. (Endocrinology94: 591, 1974)
