Shiyu Cheng

Institute of Biomedical Science

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Xingyu Jiang

Southern University of Science and Technology

Wenfu Zheng

National Center for Nanoscience and Technology

Lixue Tang

Capital Medical University

Sebastian J. Maerkl

École Polytechnique Fédérale de Lausanne

Nuoxin Wang

Zunyi Medical University

Li Ding

Hubei University of Chinese Medicine

Lei Mou

Ningbo Institute of Industrial Technology

Ruihua Dong

Southern University of Science and Technology

Liujun Jia

Chinese Academy of Medical Sciences & Peking Union Medical College

Shaoqin Liu

Harbin Institute of Technology

Cooperative Institutions

Chinese Academy of Sciences

University of Chinese Academy of Sciences

National Center for Nanoscience and Technology

Southern University of Science and Technology

Inserm

École Polytechnique Fédérale de Lausanne

Tianjin University

Peking University

Southwest Jiaotong University

Université Paris Cité

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A Submodular Approach to Controlled Islanding for Multi-Agent Network Stability

2022 American Control Conference (ACC) (2024)

Shiyu Cheng Andrew Clark

Submodular set function

Islanding

10.23919/acc60939.2024.10644583

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Electronic blood vessel

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Shiyu Cheng Hang Chen Li Ding Liujun Jia Lixue Tang

Summary Advances in bioelectronics have great potential to address unsolvable biomedical problems in the cardiovascular system. By using poly(L-lactide-co-ε-caprolactone) (PLC) that encapsulates the liquid metal to make flexible and bio-degradable electrical circuitry, we develop an electronic blood vessel that can integrate flexible electronics with three layers of blood vessel cells, to mimic and go beyond the natural blood vessel. It can improve the endothelization process through electrical stimulation and can enable controlled gene delivery into specific part of the blood vessel via electroporation. The electronic blood vessel has excellent biocompatibility in the vascular system and shows great patency three months post-implantation in a rabbit model. The electronic blood vessel would be an ideal platform to enable diagnostics and treatments in the cardiovascular system and can greatly empower personalized medicine by creating a direct link of vascular tissue-machine interface.

Biocompatibility

Bioelectronics

10.1101/2020.05.19.103457

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Anticoagulant Hydrogel Tubes with Poly(ɛ‐Caprolactone) Sheaths for Small‐Diameter Vascular Grafts

Advanced Healthcare Materials (2021)

Chunliang Zhang Qian Xie Ruitao Cha Li Ding Liujun Jia

Abstract Small‐diameter vascular grafts (inner diameter < 6 mm) are useful in treating cardiovascular diseases. The off‐the‐shelf small‐diameter vascular grafts for clinical applications remain a great limitation owing to their thrombogenicity or intimal hyperplasia. Herein, bilayer anticoagulant hydrogel tubes with poly( ε ‐caprolactone) (PCL) sheaths are prepared by freeze‐thawing and electrospinning, which contain nanofibrillated cellulose (NFC)/poly(vinyl alcohol) (PVA)‐heparin/poly‐ L ‐lysine nanoparticles tube as an inner layer and PCL sheath as an outer layer. The structure, anticoagulant property, and biocompatibility of the inner layer are studied. The effects of thickness of the outer layer on perfusion performance and mechanical property of hydrogel tubes with PCL sheaths (PCL‐NFC/PVA‐NPs tubes) are investigated. The effect of compliance of PCL‐NFC/PVA‐NPs tubes on their blood flow is studied by numerical simulation. The tissue compatibility and the patency of PCL‐NFC/PVA‐NPs tubes are evaluated by implantation in subcutaneous tissue of rats and carotid artery of rabbits. PCL‐NFC/PVA‐NPs tubes have prominent anticoagulation, sufficient burst pressure and good compliance similar to native arteries. PCL‐NFC/PVA‐NPs tubes facilitate infiltration of host cells and achieve active proliferation of recruited cells, which will be a promising candidate for small‐diameter vascular grafts.

Biocompatibility

Thrombogenicity

Caprolactone

10.1002/adhm.202100839

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Citations (23)

Contents

Journal of Hepatology (2013)

Maurizia Rossana Brunetto P Marcellin B. Cherubini Cihan Yurdaydın P Farci

10.1016/s0168-8278(13)00626-0

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Gelatin Methacryloyl-Adsorbed Calcium Phosphate Nanoparticles for 3D Printing of Bone Repair Scaffolds via Digital Light Processing

ACS Applied Nano Materials (2025)

Xiong Xiong Qing Qing Shiyu Cheng Rupan Yuan Dan Yang

Gelatin

10.1021/acsanm.5c00400

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Microfluidics for Biomedical Applications

Elsevier eBooks (2018)

Shiyu Cheng Jinqi Deng Wenfu Zheng Xingyu Jiang

10.1016/b978-0-12-801238-3.11029-3

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Triangular-shaped molecular random tiling and molecular rotation in two-dimensional glassy networks

Nanoscale (2014)

Yongtao Shen Ke Deng Songlin Yang Bo Qin Shiyu Cheng

Macrocycle-1 molecules can self-assemble into glassy state networks via van der Waals force and form many triangular nanopores in networks. The nanopores can be expressed by triangular tilings, which lead to a particularly rich range of arrangements. Moreover an interesting molecular rotation phenomenon was observed in the glassy networks.

Nanopore

10.1039/c4nr01595a

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Citations (9)

Printable Metal-Polymer Conductors for Highly Stretchable Bio-Devices

iScience (2018)

Lixue Tang Shiyu Cheng Luyao Zhang Hanbing Mi Lei Mou

Stretchable, biocompatible devices can bridge electronics and biology. However, most stretchable conductors for such devices are toxic, costly, and regularly break/degrade after several large deformations. Here we show printable, highly stretchable, and biocompatible metal-polymer conductors by casting and peeling off polymers from patterned liquid metal particles, forming surface-embedded metal in polymeric hosts. Our printable conductors present good stretchability (2,316 S/cm at a strain of 500%) and repeatability (ΔR/R <3% after 10,000 cycles), which can satisfy most electrical applications in extreme deformations. This strategy not only overcomes large surface tension of liquid metal but also avoids the undesirable sintering of its particles by stress in deformations, such that stretchable conductors can form on various substrates with high resolution (15 μm), high throughput (∼2,000 samples/hour), and low cost (one-quarter price of silver). We use these conductors for stretchable circuits, motion sensors, wearable glove keyboards, and electroporation of live cells.

10.1016/j.isci.2018.05.013

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Citations (136)

Large-scale production of Au nanoparticles as medical antibiotics

Authorea (Authorea) (2024)

Hongyu Meng Shiyu Cheng Yekkuni L. Balachandran Wei Zhang Xingyu Jiang

Here we present a process of producing AuNPs in large scale upon further development of the bench scale experiment. We produce the AuNPs-based medical dressing by using the dyeing and finishing machine. The AuNPs and related products are very promising in medical applications.

10.22541/au.170667707.78309347/v1

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FPD: Feature Pyramid Knowledge Distillation

Lecture notes in computer science (2023)

Qi Wang Lu Liu Wenxin Yu Zhiqiang Zhang Yu‐xin Liu

Feature (linguistics)

Pyramid (geometry)

Representation

10.1007/978-3-031-30105-6_9

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Citations (2)