Josep Corominas

Institute for Bioengineering of Catalonia

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Joan Albanell

Hospital Del Mar

Sònia Servitja

Hospital Del Mar

Marta Salido

Hospital Del Mar

Federico Rojo

Centro de Investigación Biomédica en Red de Cáncer

Ana Rovira

Hospital Del Mar

Ignasi Tusquets

Hospital Del Mar

Françesc Solé

Josep Carreras Leukaemia Research Institute

Sergi Serrano

Hospital Del Mar

Xavier Castells

Hospital Del Mar

María Sala

Hospital Del Mar

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Hospital Del Mar

119

Universitat Autònoma de Barcelona

Municipal Institute for Medical Research

Hospital del Mar Research Institute

Universitat de Barcelona

Parc de Salut

Instituto de Salud Carlos III

Pompeu Fabra University

Hospital Clínic de Barcelona

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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Recursos didàctics. Primària. Medi Natural

Guix: Elements d'acció educativa (1999)

Josep Corominas

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Pharmacodynamics: biological activity of targeted therapies in clinical trials

Clinical & Translational Oncology (2007)

Federico Rojo Alba Dalmases Josep Corominas Joan Albanell

Pharmacodynamics

10.1007/s12094-007-0116-2

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Masonería, laicismo y librepensamiento

Ateneo: revista cultural del Ateneo de Cádiz (2005)

Josep Corominas

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Generació d'electricitat en plaques fotovoltaiques : seqüència didàctica per a l'estudi de les plaques fotovoltaiques

Víctor López Simó R. Pintó Cristina Simarro Rodríguez Josep Corominas

Treball que correspon a les practiques que es fan als tallers REVIR organitzats pel CRECIM de la UAB. La sequencia preten que l’alumnat de segon a quart d’ESO assoleixi una major comprensio del fenomen de la generacio d’electricitat a partir de plaques fotovoltaiques.

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Nuevo material neo-eneolítico en la comarca de Bañolas

Empúries: revista de món clàssic i antiguitat tardana (1944)

Josep Corominas

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Hallazgo de ocho dracmas y cuatro divisores ampuritanos en Seriña

Empúries: revista de món clàssic i antiguitat tardana (1944)

Josep Corominas

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Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer

Oncotarget (2013)

Alba Dalmases Irene González Sílvia Menéndez Oriol Arpí Josep Corominas

// Alba Dalmases 1,2 , Irene González 1,2 , Silvia Menendez 1,2 , Oriol Arpí 1,2 , Josep Maria Corominas 3 , Sonia Servitja 1,2 , Ignasi Tusquets 1,2,4 , Cristina Chamizo 5 , Raúl Rincón 5 , Lluis Espinosa 1 , Anna Bigas 1 , Pilar Eroles 6 , Jessica Furriol 6 , Anna Lluch 7,8 , Ana Rovira 1,2 , Joan Albanell 1,2,9 , Federico Rojo 1,5 1 Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; 2 Medical Oncology Department, Hospital del Mar, Barcelona, Spain; 3 Pathology Department, Hospital del Mar, Barcelona, Spain; 4 Autonomous University of Barcelona, Spain; 5 Pathology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain; 6 Institute of Health Research INCLIVA, Valencia, Spain; 7 Oncology and Hematology Department, Hospital Clinico Universitario, Valencia, Spain; 8 Valencia Central University, Spain; 9 Universitat Pompeu Fabra, Barcelona, Spain. Correspondence: Federico Rojo, email: // Keywords : breast cancer, chemoresistance, NF-кB, p53, prognosis Received : October 31, 2013 Accepted : November 21, 2013 Published : November 23, 2013 Abstract NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional relevance at transcriptional level on NF-кB -dependent genes and the biological consequences are unclear. We studied NF-кB -dependent gene expression induced by doxorubicin in breast cancer cells and fresh human cancer specimens with different genetic backgrounds focusing on their p53 status. NF-кB –dependent signature of doxorubicin was identified by gene expression microarrays in breast cancer cells treated with doxorubicin and the IKKβ-inhibitor MLN120B, and confirmed ex vivo in human cancer samples. The association with p53 was functionally validated. Finally, NF-кB activation and p53 status was determined in a cohort of breast cancer patients treated with adjuvant doxorubicin-based chemotherapy. Doxorubicin treatment in the p53-mutated MDA-MB-231 cells resulted in NF-кB driven-gene transcription signature. Modulation of genes related with invasion, metastasis and chemoresistance ( ICAM-1 , CXCL1 , TNFAIP3 , IL8 ) were confirmed in additional doxorubicin-treated cell lines and fresh primary human breast tumors. In both systems, p53-deficient background correlated with the activation of the NF-кB –dependent signature. Furthermore, restoration of p53WT in the mutant p53 MDA-MB-231 cells impaired NF-кB driven transcription induced by doxorubicin. Moreover, a p53 deficient background and nuclear NF-кB /p65 in breast cancer patients correlated with reduced disease free-survival. This study supports that p53 deficiency is necessary for a doxorubicin driven NF-кB -response that limits doxorubicin cytotoxicity in breast cancer and is linked to an aggressive clinical behavior.

10.18632/oncotarget.1556

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Això va de química

Perspectiva escolar (2015)

Josep Corominas

En parlar de quimica sovint els estudiants associen la classe a formular i calcular i aixi acaben amb un cert desencis respecte al que esperavem d’una classe de ciencies. En aquest article es proposen unes quantes activitats practiques tant per als que s’inicien en la quimica com per a estudiants que ja n’han seguit algun curs.

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Infrarrojos, luz y ultravioletas

Aula de innovación educativa (2002)

Josep Corominas

En este articulo se presenta un conjunto de actividades para realizar preferentemente en el segundo ciclo de la ESO que tie-nen corno finalidad dar a conocer los efectos de las diferentes radiaciones electromagneticas en la atmosfera y en las plantas.

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Patatas y huevos osmóticos

Revista eureka sobre enseñanza y divulgación de las ciencias (2010)

Josep Corominas

Para ilustrar el fenomeno de la osmosis se presentan dos experiencias sencillas que pueden realizarse con materiales cotidianos (patatas, huevos, agua, sal, vinagre...), tanto a nivel cualitativo como cuantitativo.

10.2526/32

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