Kátia Cristina Dantas

Universidade de São Paulo

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Co-Authors

Roseli Santos de Freitas

Universidade de São Paulo

Thaís Mauad

Universidade de São Paulo

Estela Maria Novak

Universidade de São Paulo

Sérgio Paulo Bydlowski

National Institute of Science and Technology in Regenerative Medicine

Regiani Carvalho-Oliveira

Universidade de São Paulo

Paulo Ricardo Criado

Faculdade de Medicina do ABC

Paulo Hilário Nascimento Saldiva

Universidade de São Paulo

José Eduardo Levi

Universidade de São Paulo

Martin Metzger

Universidade de São Paulo

José Eduardo Martins

Universidade do Vale do Rio dos Sinos

Cooperative Institutions

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Brasil

Instituto de Medicina Tropical

Instituto de Medicina Avançada

Hospital Universitário da Universidade de São Paulo

Hospital São Paulo

Fundação Pró-Sangue Hemocentro de São Paulo

Universidade Federal de São Paulo

Centro Universitário das Faculdades Metropolitanas Unidas

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Sustained Decrease in Superoxide Dismutase Activity Underlies Constrictive Remodeling After Balloon Injury in Rabbits

Arteriosclerosis Thrombosis and Vascular Biology (2003)

Paulo Ferreira Leite Alexandre Danilovic Patrícia Moriel Kátia Cristina Dantas Stefan L. Marklund

The redox pathophysiology of vascular repair is incompletely understood. We assessed the role of vascular superoxide dismutase (SOD) activity in oxidative/nitrative stress and caliber loss postinjury (PI).Rabbits submitted to iliac artery balloon overdistension were followed for 14 days PI. Significant decrease in vascular SOD activity occurred at 7 and 14 days PI (by 45% and 34%, respectively, versus control, 96+/-1 U/mg, P<0.05). Separation in concanavalin-A column showed that both extracellular SOD (ecSOD) and CuZn SOD activities were reduced, whereas Western analysis showed normal or augmented protein expression. Immunoreactivity to nitrotyrosine, neuronal NO synthase (NOS), and inducible NOS (iNOS) increased in media and neointima PI; iNOS mRNA also augmented. Administration of ecSOD from days 7 to 14 PI corrected the SOD activity decrease and minimized caliber loss by 59% (P=0.007) despite unaltered neointima. Nitrate levels markedly increased with ecSOD in injured artery homogenates (26+/-5 versus 4+/-0.3 micromol/L per mg, P=0.001). Such increase was 70% inhibited by specific iNOS antagonist 1400w. Nitrotyrosine and neuronal NOS expression decreased after ecSOD.Sustained low vascular SOD activity has a key role in constrictive remodeling after injury, promoting oxidative/nitrative stress and impairment of iNOS-derived NO bioavailability. SOD function may critically determine whether iNOS induction is beneficial or deleterious in vivo.

Neointima

Nitrotyrosine

10.1161/01.atv.0000093980.46838.41

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Citations (68)

Micoses superficiais e os elementos da resposta imune

Anais Brasileiros de Dermatologia (2011)

Paulo Ricardo Criado Cristiane Beatriz de Oliveira Kátia Cristina Dantas Filomena Amaro Takiguti L. Benini

As micoses superficiais são prevalentes em todo o mundo, geralmente ocasionadas por dermatófitos e restritas à camada córnea. A resposta imunológica do hospedeiro às infecções dos fungos dermatófitos depende basicamente das defesas do hospedeiro a metabólitos do fungo, da virulência da cepa ou da espécie infectante e da localização anatômica da infecção. Serão revistos alguns dos fatores da defesa imunológica do hospedeiro que influenciam na eficácia da resposta imune. Em especial, a participação dos receptores de padrão de reconhecimento (PRRs), tais como os receptores toll-like ou os da família lectina (DC-SIGN e dectin-2), que participam da resposta imune inata, conferindo-lhe especificidade e definindo o padrão da resposta imune como um todo. O predomínio celular ou humoral da resposta imune definirá o quadro clínico e o prognóstico da infecção, levando à cura ou cronicidade

10.1590/s0365-05962011000400015

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The use of nested Polymerase Chain Reaction (nested PCR) for the early diagnosis of Histoplasma capsulatum infection in serum and whole blood of HIV-positive patients*

Anais Brasileiros de Dermatologia (2013)

Kátia Cristina Dantas Roseli Santos de Freitas Adriana Pardini Vicentini Moreira Marcos Silva Gil Benard

The aim of the study was to detect the rDNA sequences and their regions in Histoplasma capsulatum, which could be considered species-specific and used as a molecular method for this diagnosis by the technique of nested polymerase chain reaction (nested PCR), employing specific sequences (primers) for H. capsulatum: 18S rDNA region (HC18), 100 kDa (HC100) and the sequence 5.8 S-ITS rDNA (HC5.8). The PCR sequences HC18, HC100 and HC5.8 resulted in a specificity of 100%. The molecular assays may increase the specificity, sensitivity and speed in the diagnosis of Histoplasmosis.

Histoplasma

10.1590/s0365-05962013000100025

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Citations (25)

Experiência da primeira composteira na Faculdade de Medicina da Universidade de São Paulo

Cadernos de Agroecologia (2020)

Paulo Sergio Zembruski Márcia Saldanha Kubrusly Regiani Carvalho-Oliveira Kátia Cristina Dantas Thaís Mauad

The composite of the Faculty of Medicine of USP (FMUSP) began in 2018, with thermophilic compost as it´s chosen method. In order to reuse the material resulting from the pruning of the garden (FMUSP) and the damp garbage from the restaurant. After the workshop where the garden and restaurant staff participated, the composting continued until reaching the maximum height indicated, when it entered rest period until being opened and have the compound taken advantage of. The objective of being an example within the city of Sao Paulo was reached in the numerous visits received to know and understand how the UFSC method of composting works.

Pruning

Source

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Association of hepatic nuclear factor-4 in the apolipoprotein B promoter: a preliminary report

Brazilian Journal of Medical and Biological Research (1998)

Estela Maria Novak Kátia Cristina Dantas Charlotte Charbel Sérgio Paulo Bydlowski

Previous studies have examined the arrangement of regulatory elements along the apolipoprotein B (apoB) promoter region (-3067 to +940) and a promoter fragment extending from nucleotides -150 to +124 has been demonstrated to be essential for transcriptional activation of the apoB gene in hepatic and intestinal cells. It has also been shown that transcriptional activation of apoB requires a synergistic interaction between hepatic nuclear factor-4 (HNF-4) and CCAAT/enhancer-binding protein alpha (C/EBP alpha) transcription factors. Here, we have examined the hypothesis that HNF-4 factor binding to DNA may induce a DNA helix bend, thus facilitating the communication with a C/EBP alpha factor located one helix turn from this HNF-4 factor in the apoB promoter. A gel electrophoretic mobility shift assay using wild type double-stranded oligonucleotides or modified wild type duplex oligonucleotides with 10 nucleotides inserted between HNF-4 and C/EBP alpha factor motifs showed similar retarded complexes, indicating that HNF-4 and C/EBP alpha factors interact independently of the distance between binding sites. However, when only one base, a thymidine, was inserted at the -71 position of the apoB promoter, the complex shift was completely abolished. In conclusion, these results regarding the study of the mechanisms involving the interaction between HNF-4 and C/EBP alpha factors in the apoB promoter suggest that the perfect 5'-CCCTTTGGA-3' motif is needed in order to facilitate the interaction between the two factors.

Factor (programming language)

10.1590/s0100-879x1998001100006

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Citations (7)

Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report

The Journal of venomous animals and toxins including tropical diseases (2014)

Kátia Cristina Dantas Roseli Santos de Freitas R.S. Garcia Marcos da Silva Edna Cleide Mendes Muricy

This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity against Histoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for H. capsulatum and Cryptococcus neoformans. The evaluation of paucisymptomatic patients with positive results for H. capsulatum and C. neoformans could be relevant for the prevention as well as the possible evaluation of the reactivated quiescent foci. In conclusion, the associated methodology may have contributed to the monitoring endogenous reactivation of these diseases.

Histoplasma

10.1186/1678-9199-20-36

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Citations (6)

Microplastics in the Olfactory Bulb of the Human Brain

JAMA Network Open (2024)

Luís Fernando Amato‐Lourenço Kátia Cristina Dantas Gabriel Ribeiro Júnior Vítor Ribeiro Paes Rômulo A. Ando

Microplastic (MP) pollution is an emerging environmental and health concern. While MPs have been detected in various human tissues, their presence in the human brain has not been documented, raising important questions about potential neurotoxic effects and the mechanisms by which MPs might reach brain tissues.

Human brain

Brain tissue

10.1001/jamanetworkopen.2024.40018

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Citations (8)

Evaluation of phenotypic and genotypic alterations induced by long periods of subculturing of Cryptococcus neoformans strains

Memórias do Instituto Oswaldo Cruz (2007)

Sonia Cristina Cavalcante Roseli Santos de Freitas Mónica Vidal Kátia Cristina Dantas José Eduardo Levi

Cryptococcus neoformans is an encapsulated fungal organism that can cause disease in apparently immunocompetent, as well as immunocompromised, hosts. Since 1930, successive subculture has been used to preserve C. neoformans isolates in our Fungus Collection. In the 1970s, some of these Fungus Collection samples were selected to be subjected to a different methods of maintenance - that of lyophilized. Our objective was to analyze C. neoformans isolates in order to make a comparative evaluation between these two methods of preservation. The overall aim of this study was to qualify the preservation technique used in our mycology laboratory since the technique used might affect the survival, stability and purity of the primary isolates in culture. The samples were analyzed using classical mycology methods and using the randomly amplified polymorphic DNA technique In the analysis of phenotypes and genotypes, the typical characteristics of C. neoformans were found to differ in relation to the different methods of preservation employed. The aim of this study was to demonstrate the importance of selecting the appropriate method of preservation for fungus collections. This selection can affect the survival and purity of the cultures, and preserve the stability of their physiological, biochemical, and genetic characteristics.

Subculture (biology)

Mycology

10.1590/s0074-02762007000100006

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Citations (17)

The Respiratory Tract Plays a Pivotal Role in the Pathogenesis of Fatal Yellow Fever: An Autopsy Study from the 2017-2019 Yellow Fever Epidemic

Amaro Nunes Duarte‐Neto Kátia Cristina Dantas Suzete C. Ferreira Fernando Rabioglio Giugni Marielton dos Passos Cunha

Pathogenesis

Respiratory tract

10.2139/ssrn.5112768

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A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil

Scientific Reports (2021)

Kátia Cristina Dantas Thaís Mauad Carmen Diva Saldiva de André Ana Luiza Bierrenbach Paulo Hilário Nascimento Saldiva

Abstract Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available data on fungal infections obtained from autopsy reports during 85 years of autopsies performed by the largest autopsy service in Brazil. All invasive fungal infections presented in autopsy reports between 1930 and 2015 were included. Of the 158,404 autopsy reports analysed, 1096 involved invasive fungal infections. In general, paracoccidioidomycosis (24%) was the most frequent infection, followed by candidiasis (18%), pneumocystosis (11.7%), cryptococcosis (11%), aspergillosis (11%) and histoplasmosis (3.8%). Paracoccidioidomycosis decreased after the 1950s, whereas opportunistic fungal infections increased steadily after the 1980s during the peak of the AIDS pandemic. The lung was the most frequently affected organ (73%). Disseminated infection was present in 64.5% of cases. In 26% of the 513 cases for which clinical charts were available for review, the diagnosis of opportunistic fungal infections was performed only at autopsy. Our unique 85-year history of autopsies showed a transition from endemic to opportunistic fungal infections in São Paulo, Brazil, reflecting increased urbanization, the appearance of novel diseases, such as AIDS in the 1980s, and advances in medical care over time.

Pneumocystosis

10.1038/s41598-021-83587-1

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Citations (33)