Laurine Conraux

Institute Cancer De La Loire Lucien Neuwirth

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Wafa Bouleftour

Centre Hospitalier Universitaire de Saint-Étienne

Jean-Philippe Suchaud

Centre Léon Bérard

Nicolas Magné

Institute Cancer De La Loire Lucien Neuwirth

Fabien Tinquaut

Centre Hospitalier Universitaire de Saint-Étienne

ÉD

Élisabeth Daguenet

Institute Cancer De La Loire Lucien Neuwirth

Pablo Moreno‐Acosta

Instituto Nacional de Cancerología

Kevin Grangeon

Institute Cancer De La Loire Lucien Neuwirth

Jean‐Baptiste Guy

CEA LITEN

C. Rancoule

Nantes Université

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Institute Cancer De La Loire Lucien Neuwirth

Centre Hospitalier Universitaire de Saint-Étienne

Université Claude Bernard Lyon 1

Inserm

Centre National de la Recherche Scientifique

Hôpital Nord

Institut Bergonié

Université Jean Monnet

Centre Léon Bérard

Centre de Radiothérapie Bayard

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Impact of Radiation Therapy on Biological Parameters in Cancer Patients: Sub-analysis from the RIT Prospective Epidemiological Study

Cancer Investigation (2022)

Nicolas Magné Élisabeth Daguenet Wafa Bouleftour Laurine Conraux Fabien Tinquaut

Scarce data investigate the impact of radiotherapy (RT) on biology markers. An analysis of ancillary study of RIT (Radiation Impact on Thromboembolic events) prospective trial was carried out. All patients with non-metastatic solid tumors and treated with radiotherapy and/or brachytherapy in curative and consenting to have blood samples were included. A significant decrease in white blood count, (i.e. lymphocytes, monocytes, neutrophils and basophils) and platelet counts was observed after RT and maintained at 6 months. Whereas, eosinophils, D-dimers and hemoglobin levels were affected respectively 3 months and 6 months after RT initiation. Conversely, red cells count and CRP level were not affected by RT. This study is an advocacy to develop an understanding of basic immune system in relation with RT.

White blood cell

10.1080/07357907.2022.2139838

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Citations (4)