Mostafa M. Ghorab

Egyptian Atomic Energy Authority

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Mansour S. Alsaid

Ras al-Khaimah Medical and Health Sciences University

105

Fatma A. Ragab

Cairo University

Helmy I. Heiba

Egyptian Atomic Energy Authority

Aiten M. Soliman

Egyptian Atomic Energy Authority

Hazem A. Ghabbour

King Saud University

Marwa G. El‐Gazzar

Egyptian Atomic Energy Authority

Saleh I. Alqasoumi

King Saud University

Eman Noaman

Egyptian Atomic Energy Authority

Hoong‐Kun Fun

King Saud University

M. S. A. El‐Gaby

Al-Azhar University

Cooperative Institutions

King Saud University

Al-Azhar University

Cairo University

Egyptian Atomic Energy Authority

National Research Centre

Al-Azhar University

Ain Shams University

National Water Research Center

Mansoura University

Assiut University

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Synthesis and evaluation of some new fluorinated hydroquinazoline derivatives as antifungal agents

Il Farmaco (2000)

Mostafa M. Ghorab S. M. Abdel‐Gawad M. S. A. El‐Gaby

10.1016/s0014-827x(00)00029-x

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Citations (102)

New Biologically Active N-(Tetrahydrobenzothienopyrimidin-4-YL)-Amino Acids, Thiourethane, Sulfonamides and Related Compounds

Phosphorus, sulfur, and silicon and the related elements (2000)

Mostafa M. Ghorab

Abstract Some derivatives of thieno[2,3-d]pyrimidine containing amino acids 3a-i, imidazoles 4a-f, isothiocyanate 5, thiourethane 6, triazine 8, pyrimidine 10, sulphonamides 13a-d, 14, pyrazole 16 and pyrazolone 17 were synthesized. The structural assignments of the new compounds were based on analytical, spectroscopic measurements and chemical reactions. Some of the obtained compounds showed interesting antimicrobial activities.

Pyrazolones

Phenyl isothiocyanate

Pyrazole

Triazine

Sulfonamide

10.1080/10426500008076341

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Citations (15)

Factorial design-optimized and gamma irradiation-assisted fabrication of selenium nanoparticles by chitosan and Pleurotus ostreatus fermented fenugreek for a vigorous in vitro effect against carcinoma cells

International Journal of Biological Macromolecules (2019)

Ahmed I. El‐Batal Farag M. Mosallam Mostafa M. Ghorab Amro Hanora Mohamed Gobara

Pleurotus ostreatus

Hep G2

Biopolymer

Pectin

10.1016/j.ijbiomac.2019.11.210

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Citations (50)

REACTIONS WITH ETHYL-4,5,6,7-TETRAHYDRO-2-ISOTHIOCYANATO-1-BENZOTHIOPHENE-3-CARBOXYLATE. SYNTHESIS OF SOME NOVEL HETEROCYCLIC COMPOUNDS WITH POTENTIAL HYPNOTIC ACTIVITY

Phosphorus, sulfur, and silicon and the related elements (1995)

Mostafa M. Ghorab H. I. Heiba Mona A. El-gawish

Abstract Ethyl-4,5,6,7-tetrahydro-2-isothiocyanato-1-benzothiophene-3-carboxylate (2), prepared from ethyl-4,5,6,7-tetrahydro-2-amino-1-benzothiophene-3-carboxylate (1) by the thiophosgene method, was converted with nucleophiles into benzothieno[2,3-d]pyrimidine derivatives (3–5) and (7) either directly or through thiourethane (6a). The tricyclic, benzothienopyrimidine systems (8) and (9) were obtained either from the isothiocyanate (2) or the thiourethane (6a), while the tetracyclic systems, triazolothienopyrimidines (10,11); tetrazolothienopyrimidines (12,13) and tetrazepino derivative (14), were obtained from 2,3,5,6,7,8-hexahydro-3-amino-2-hydrazino-1-benzothieno[2,3-d]pyrimidine-4(3H)-one (9). Preliminary pharmacological screening revealed that some of the new compounds exhibited hypnotic activity.

Benzothiophene

Carboxylate

Derivative (finance)

Tricyclic

10.1080/10426509508027893

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Citations (11)

SYNTHESIS AND RADIATION STABILITY OF NOVEL THIAZOLOPYRIMIDINES WITH EXPECTED ANTIFUNGAL ACTIVITY

Phosphorus, sulfur, and silicon and the related elements (1996)

Mostafa M. Ghorab Y. A. Mohamed S. A. MOHAMED Yousry A. Ammar

Abstract A number of thiazolopyrimidines (II–VII) were prepared through interaction of 6-methyl-4(4′-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester (Ia) with many reagents. The antifungal activity of all prepared compounds have been determined using Dithane M-45 as a standard fungicide. Some compounds showed a high fungicidal activity equivalent to that of the standard towards Aspergillus niger and Aspergillus ochraceus. Also some biologically active compounds were subjected to gamma irradiation and the structures are stable.

Aspergillus niger

Aspergillus ochraceus

10.1080/10426509608029657

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Citations (40)

Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane

Il Farmaco (2000)

Mostafa M. Ghorab A. M. SH. EL‐SHARIEF Yousry A. Ammar Sh. I. Mohamed

10.1016/s0014-827x(00)00051-3

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Citations (43)

Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway

European Journal of Medicinal Chemistry (2020)

Aiten M. Soliman Heba M. Karam Mai H. Mekkawy Mostafa M. Ghorab

Acetamide

Moiety

Docking (animal)

10.1016/j.ejmech.2020.112333

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Citations (46)

Dapson in Heterocyclic Chemistry, Part IV: Synthesis of Some Novel Diphenylsulfones Containing Acetamide, Pyrrolidine, Piperazine, and Thiomorpholine Moieties as Antimicrobial and Antitumor Agents

Phosphorus, sulfur, and silicon and the related elements (2008)

Mostafa M. Ghorab M. S. A. El‐Gaby N. E. Amin N. M. TAHA M. A. Shehab

Interaction of dapson [bis(4-aminophenyl)sulfone] 1 with [bis-(methylsulfonyl) methylidine]malononitrile 2 yielded the corresponding dicyano derivative 3, which was reacted with acetic anhydride, succinic anhydride, 4-chlorobenzaldehyde, phenyl isothiocyanate to give the corresponding acetamide 4, succinamic acid 5, pyrrolidine 6, Shiff base 7 and thiourea 8, respectively. Treatment of 3 with chloroacetyl chloride afforded the aminoacetyl chloride derivative 9. Further, the interaction of compound 9 with thioglycolic acid, malononitrile, ethyl glycinate hydrochloride, and/or potassium thiocyanate furnished compounds 10–15, respectively. The structural characterization of the prepared compounds was based on microanalytical and spectroscopic analyses. Some of the prepared compounds were tested for their antimicrobial and antitumor activities. Compounds 9 and 12 showed promising antitumor activity compared with Doxorubicin as positive control.

Acetamide

Phenyl isothiocyanate

Chloroacetyl chloride

Acetyl chloride

Thioglycolic acid

Succinic anhydride

Potassium thiocyanate

Benzoyl chloride

Chloroacetic acid

10.1080/10426500802505457

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Citations (7)

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides

Journal of Enzyme Inhibition and Medicinal Chemistry (2014)

Mostafa M. Ghorab Maureen Higgins Mansour S. Alsaid Reem K. Arafa Abdelaaty A. Shahat

In biological systems, the Keap1/Nrf2/antioxidant response element pathway determines the ability of mammalian cells to adapt and survive conditions of oxidative, electrophilic and inflammatory stress by regulating the production of cytoprotective enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1, EC 1.6.99.2) being one of them. Novel biologically active benzenesulfonamides 2, 3, 5–7, penta-2,4-dienamide 4 and chromene-2-carboxamide 8 structurally augmented with an electron-deficient Michael acceptor enone or cyanoenone functionalities were prepared. A new biological activity was conferred to these molecules, that of induction of NQO1. The potency of induction was increased by incorporation of a nitrile group adjacent to the enone and the dinitrophenyl derivative 3 was the most promising inducer. Also, molecular docking of the new compounds in the Nrf2-binding site of Keap1 was performed to assess their ability to inhibit Keap1 which biologically leads to a consequent Nrf2 accumulation and enhanced gene expression of NQO1. Docking results showed considerable interactions between the new molecules and essential binding site amino acids.

Enone

Docking (animal)

KEAP1

10.3109/14756366.2013.858146

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Citations (7)

ChemInform Abstract: In vitro Cytotoxic Evaluation of Some New Heterocyclic Sulfonamide Derivatives.

ChemInform (2011)

Mostafa M. Ghorab Mansour S. Alsaid Ebaa M. El‐Hossary

Abstract A variety of new quinoline, pyrimidoquinoline and oxazinoquinoline derivatives bearing a sulfonamide moiety is synthesized and evaluated for their anticancer activities.

Sulfonamide

Quinoline

Moiety

10.1002/chin.201142147

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Citations (0)