Jing Tang

Fuzhou University

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Gengfeng Zheng

Fudan University

Biao Kong

Fudan University

Yongcheng Wang

Zhejiang University

Xinwang Yang

Kunming Medical University

Dongyuan Zhao

Fudan University

Yi Cui

Stanford University

Cordelia Selomulya

UNSW Sydney

Man‐Cheng Hu

Shaanxi Normal University

Shu-Ni Li

Shaanxi Normal University

Zhe Fu

Malaghan Institute of Medical Research

Cooperative Institutions

Chinese Academy of Sciences

148

Fudan University

123

Stanford University

119

Sun Yat-sen University

Kunming Medical University

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Tsinghua University

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OM‐LV20, a novel peptide from odorous frog skin, accelerates wound healing in vitro and in vivo

Chemical Biology & Drug Design (2017)

Xiaojie Li Ying Wang Zhirong Zou Meifeng Yang Chunyun Wu

The healing of chronic wounds remains a considerable challenge in clinical trials and imposes severe financial and physiological burdens on patients. Many works are being tried to find ideal clinical promoting wound healing biomaterials. Small bioactive peptides with low cost and easy production, store and transfer become excellent candidates. Here, we identified a novel peptide (named OM-LV20) from skin secretions of odorous frog Odorrana margaretae. The peptide had an amino acid sequence of "LVGKLLKGAVGDVCGLLPIC," contained an intramolecular disulfide bridge at the C-terminus, and was produced by post-translational processing of a 71-residue prepropeptide. Our results showed that OM-LV20 had no direct microbe-killing effects, hemolytic activity, or acute toxicity, but did exhibit weak antioxidant activity. OM-LV20 promoted wound healing against human keratinocytes (HaCaT) and human skin fibroblasts (HSF) in both time- and dose-dependent manners. In addition, it induced the proliferation of HaCaT but not HSF cells. Of note, OM-LV20 showed strong wound healing-promoting activity in a mice model of full-thickness skin wound. Our research indicates the cellular and animal level wound healing potential of OM-LV20, and thus provides a novel bioactive peptide template for the development of wound healing agents and medicine.

10.1111/cbdd.13063

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Citations (57)

Anion Etching for Accessing Rapid and Deep Self-Reconstruction of Precatalysts for Water Oxidation

Matter (2020)

Yang Wang Yinlong Zhu Shenlong Zhao Sixuan She Fei-Fei Zhang

Oxygen evolution

10.1016/j.matt.2020.09.016

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Citations (224)

Modeling multiple failures of composite box beams used in wind turbine blades

Composite Structures (2019)

Xiao Chen Jing Tang Ke Yang

Material failure theory

10.1016/j.compstruct.2019.03.018

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Citations (33)

Carbon Nanodots Featuring Efficient FRET for Real‐Time Monitoring of Drug Delivery and Two‐Photon Imaging

Advanced Materials (2013)

Jing Tang Biao Kong Hao Wu Ming Xu Yongcheng Wang

A FRET-based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real-time monitoring of drug release. Moreover, the FRET-based two-photon imaging and drug tracking in deep tissues are also demonstrated. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Nanodot

Biocompatibility

10.1002/adma.201303124

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Citations (531)

YY-39, a tick anti-thrombosis peptide containing RGD domain

Peptides (2014)

Jing Tang Yaqun Fang Yajun Han Xuewei Bai Xiuwen Yan

10.1016/j.peptides.2014.08.008

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Citations (25)

CCDC 2035590: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Dan Zheng Ting‐Hong Huang Cheng Luo Jing Tang

10.5517/ccdc.csd.cc26b66z

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Citations (0)

A new mixed-ligand Co(II) coordination polymer: treatment activity on ulcerative colitis by inhibiting the JAK2/STAT3 signaling pathway in the colonic epithelial cells

Figshare (2020)

Yan Tan Hong-Yu Yun Jing Tang Du-Xiong Cai Xiaoning Sun

In the current study, a novel mixed-ligand coordination polymer, {[Co(L)(dpe)]·(ClO₄)} (1) (H₂LCl = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = (E)-1,2-di(pyridin-4-yl)ethene), was synthesized under hydrothermal conditions by a zwitterionic organic ligand and fully characterized by the single crystal X-ray diffraction, powder X-ray diffraction, elemental analysis along with the FT-IR. Furthermore, the treatment activity of the compound on the ulcerative colitis was evaluated and the related mechanism was explored. First, the level of the tumor necrosis factor (TNF)-α and superoxide dismutase (SOD) released by the colon tissue into the plasma was measured with enzyme-linked immunosorbent assay (ELISA) detection kit. In addition to this, the activation level of the JAK2/STAT3 signaling pathway in the colonic epithelial cells was also determined with western blot. With the help of molecular docking simulation, the potential interacting gestures between the complex and the protein have been revealed.

Coordination polymer

10.6084/m9.figshare.12852252

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Citations (0)

A novel peptide from the skin of amphibian Rana limnocharis with potency to promote skin wound repair

Natural Product Research (2020)

Siyuan Wang Chengan Feng Saige Yin Zhuo Feng Jing Tang

In clinical trials, the healing of wounds remains a substantial physiological and financial incumbrance on patients. Therefore, the development of new drugs that can accelerate wound healing is vital. Based on genomic methods, we identified a new peptide (RL-RL10) with the amino acid sequence 'RLFKCWKKDS' from the skin of an amphibian frog species (Rana limnocharis). RL-RL10 promoted wound healing of human keratinocytes (HaCaT) in a concentration-dependent manner. RL-RL10 also had an effect on the migration and proliferation of HaCaT cells and promoted healing of a full-thickness wound in mice in a dose-dependent manner. In conclusion, we discovered RL-RL10 that promoted healing activity of cellular and animal wounds, thus providing a new peptide template for the development of novel wound-repairing drugs.

HaCaT

10.1080/14786419.2019.1710702

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Citations (13)

CGD: a multi-omics database for chrysanthemum genomic and biological research

Horticulture Research (2024)

Jingxuan Ye Chun Wang Ye Liu Shaocong Chen Jinyu Jin

Asteraceae is the largest family of dicotyledons and includes

Omics

10.1093/hr/uhae238

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Citations (0)